Quantitative ultrasound imaging to assess skeletal muscles in adults with multiple sclerosis: A feasibility study

Gao, Jing; Memmott, Benjamin; Poulson, Jonathan

doi:10.1016/j.ultrasmedbio.2019.07.549

Cited by 2 publications

(1 citation statement)

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“…However, it is not a direct measure of muscle strain. Ultrasound (US) strain imaging has been used to measure strain and strain rate primarily in cardiac muscle (Bansal et al, 2010;Gorcsan and Tanaka, 2011;Mondillo et al, 2011;Yamada et al, 2014) though there have been several applications to skeletal muscle dynamic imaging as well (Lopata et al, 2010;Gijsbertse et al, 2017;Gao et al, 2018Gao et al, , 2019Frich et al, 2019). Most ultrasound studies are performed in 2D that allows 2D strain estimation; however, some studies have extended it to bi-plane US studies where strain can be assessed in three orthogonal directions (Gijsbertse et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

3D Muscle Deformation Mapping at Submaximal Isometric Contractions: Applications to Aging Muscle

Malis

Sinha

2020

Front. Physiol.

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3D strain or strain rate tensor mapping comprehensively captures regional muscle deformation. While compressive strain along the muscle fiber is a potential measure of the force generated, radial strains in the fiber cross-section may provide information on the material properties of the extracellular matrix. Additionally, shear strain may potentially inform on the shearing of the extracellular matrix; the latter has been hypothesized as the mechanism of lateral transmission of force. Here, we implement a novel fast MR method for velocity mapping to acquire multi-slice images at different % maximum voluntary contraction (MVC) for 3D strain mapping to explore deformation in the plantar-flexors under isometric contraction in a cohort of young and senior subjects. 3D strain rate and strain tensors were computed and eigenvalues and two invariants (maximum shear and volumetric strain) were extracted. Strain and strain rate indices (contractile and in-plane strain/strain rate, shear strain/strain rate) changed significantly with %MVC (30 and 60% MVC) and contractile and shear strain with age in the medial gastrocnemius. In the soleus, significant differences with age in contractile and shear strain were seen. Univariate regression revealed weak but significant correlation of in-plane and shear strain and shear strain rate indices to %MVC and correlation of contractile and shear strain indices to force. The ability to map strain tensor components provides unique insights into muscle physiology: with contractile strain providing an index of the force generated by the muscle fibers while the shear strain could potentially be a marker of lateral transmission of force.

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Section: Introductionmentioning

confidence: 99%

3D Muscle Deformation Mapping at Submaximal Isometric Contractions: Applications to Aging Muscle

Malis

Sinha

2020

Front. Physiol.

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Compression elastography in assessment of bicep muscle stiffness with controlled pressure in healthy adults

Ordierez Zuñiga,

Gaviria López,

Roldán Gonzáles

et al. 2024

F1000Res

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Background Ultrasound Shear Elastography (USE) is used to quantify the stiffness of biological tissues by measuring muscle deformation or displacement. Compression Elastography (CE) involves applying pressure to the skin using an ultrasound (US) transducer, resulting in tissue displacement, and is used to assess tissue stiffness based on the principle that compression produces strain. Methods In this study, we estimated the strain in the biceps brachialis of healthy volunteers (n=11) and patients with post-stroke spasticity (n=2). The arms were evaluated using the Tardieu scale and strain measurements were obtained using an ultrasound probe with the elbow flexed at 30°. A semi-automatic algorithm for muscle thickness measurement was employed to qualitatively measure muscle elasticity. The application of controlled pressure from an electromechanical actuator allows for strain estimation without direct intervention by an operator, thereby reducing subjectivity in the results. The main aim of this study was to utilize CE to characterize the normal range of muscle elasticity in the biceps brachialis of healthy volunteers who exhibited no changes and were rated 0 on the modified Tardieu scale. Results The normal range of strain for both healthy male and female volunteers demonstrated an acceptable deviation for each strain measurement, as the standard deviation was considered small and relatively constant (with higher values observed under maximum pressure). The proposed measurement mechanism is sensitive, allowing for the observation of strain differences between healthy and spastic muscles in both men and women. Conclusions Comparison of the average curve for the healthy group with two examples of curves from individuals with spasticity showed evident differences. Thus, it would be worthwhile to continue this research by evaluating a group of subjects with spastic muscles.

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Quantitative ultrasound imaging to assess skeletal muscles in adults with multiple sclerosis: A feasibility study

Cited by 2 publications

References 0 publications

3D Muscle Deformation Mapping at Submaximal Isometric Contractions: Applications to Aging Muscle

3D Muscle Deformation Mapping at Submaximal Isometric Contractions: Applications to Aging Muscle

Compression elastography in assessment of bicep muscle stiffness with controlled pressure in healthy adults

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