Quantitative trait locus analysis of ovarian cysts derived from rete ovarii in MRL/MpJ mice

Lee, Shin‐Hyo; Ichii, Osamu; Otsuka, Saori; Hashimoto, Yoshiharu; Kon, Yasuhiro

doi:10.1007/s00335-010-9254-x

Cited by 6 publications

(10 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast, the rete ovarian cysts of MRL mice showed dilation of the IR, which is mainly lined with a single-layered ciliated or non-ciliated squamous or cuboidal epithelium (Kon et al 2008), with considerably fewer pathological changes than the IR epithelium of CD-1 mice described by Long (2002). Additionally, a significant genetic linkage was obtained from the analysis of quantitative trait loci (QTL) between specific loci on chromosomes 4 or 14 and the development of ovarian cysts in MRL mice (Lee et al 2010). However, there is no evidence as to how the rete ovarii changes sequentially into an ovarian cyst in this mouse model (Kon et al 2008;Lee et al 2010).…”

Section: Introductionmentioning

confidence: 96%

“…Additionally, a significant genetic linkage was obtained from the analysis of quantitative trait loci (QTL) between specific loci on chromosomes 4 or 14 and the development of ovarian cysts in MRL mice (Lee et al 2010). However, there is no evidence as to how the rete ovarii changes sequentially into an ovarian cyst in this mouse model (Kon et al 2008;Lee et al 2010).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Ovarian cysts in MRL / MpJ mice are derived from the extraovarian rete: a developmental study

et al. 2011

Self Cite

View full text Add to dashboard Cite

MRL ⁄ MpJ (MRL) mice, commonly used as a model for autoimmune disease, have a high frequency of ovarian cysts originating from the rete ovarii. In the present study, to clarify how the rete ovarii, which are remnants of mesonephric tubules during embryogenesis, progress to cystic formation with aging, the morphology of MRL rete ovarii was analyzed and compared with that of normal C57BL ⁄ 6N (B6) mice. In B6 mice, the rete ovarii consisted of a series of tubules, including the extraovarian rete (ER), the connecting rete (CR), and the intraovarian rete (IR), based on their location. Whereas the ER of B6 mice was composed of highly convoluted tubules lined by both ciliated and non-ciliated epithelia, the tubules in the CR and IR had only non-ciliated cells. In MRL mice, dilations of the rete ovarii initiated from the IR rather than the ER or CR. Although the histological types of cells lining the lumen of the rete ovarii were the same as those in B6 mice, the ER in MRL mice showed a variety in morphology. In particular, the connections between the ER and ovary tended to disappear with increasing age and the development of ovarian cysts. Furthermore, the epithelium lining the large ovarian cysts in MRL mice had ciliated cells forming the cluster. On the basis of these findings, it is suggested that cystic changes of the rete ovarii in MRL mice are caused by the dilations of the IR with invasion of the ER and CR into the ovarian medulla. These data provide new pathological mechanisms for ovarian cyst formation.

show abstract

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Ovarian cysts in MRL / MpJ mice are derived from the extraovarian rete: a developmental study

et al. 2011

Self Cite

View full text Add to dashboard Cite

show abstract

“…Specifically, the abundance of ovarian MCs around the surface epithelial region is a novel and unique phenotype of neonatal MRL mice. We previously reported that the reproductive organs of MRL mice have unique characteristics that are controlled by several factors derived from the genomic background of this strain [21,24,26,29,31]. Although the genomic background could be one of the factors controlling the appearance of ovarian MCs, the ancestral strains of MRL mice, namely AKR, C3H/He, and B6 mice, had lower MC densities than MRL mice.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to autoimmune phenotypes, MRL mice show some unique phenotypes related to wound healing, such as accelerated ear punch closure and cardiomyocyte regeneration [19–21]. In addition, we have reported that the reproductive organs of MRL mice have other unique characteristics: specifically, metaphase-specific apoptosis of meiotic spermatocytes [22–24], heat shock resistance of spermatocytes found in experimental cryptorchidism [25,26], existence of testicular oocytes in newborn males [27–29], and development of ovarian cysts originating from the rete ovarii [30,31]. These phenotypes are closely associated with the genetic background of MRL mice, and several susceptibility loci have been identified by genomic analysis [21,24,26,29,31].…”

Section: Introductionmentioning

confidence: 99%

Relationship between Numerous Mast Cells and Early Follicular Development in Neonatal MRL/MpJ Mouse Ovaries

et al. 2013

Self Cite

View full text Add to dashboard Cite

In the neonatal mouse ovary, clusters of oocytes called nests break into smaller cysts and subsequently form individual follicles. During this period, we found numerous mast cells in the ovary of MRL/MpJ mice and investigated their appearance and morphology with follicular development. The ovarian mast cells, which were already present at postnatal day 0, tended to localize adjacent to the surface epithelium. Among 11 different mouse strains, MRL/MpJ mice possessed the greatest number of ovarian mast cells. Ovarian mast cells were also found in DBA/1, BALB/c, NZW, and DBA/2 mice but rarely in C57BL/6, NZB, AKR, C3H/He, CBA, and ICR mice. The ovarian mast cells expressed connective tissue mast cell markers, although mast cells around the surface epithelium also expressed a mucosal mast cell marker in MRL/MpJ mice. Some ovarian mast cells migrated into the oocyte nests and directly contacted the compressed and degenerated oocytes. In MRL/MpJ mice, the number of oocytes in the nest was significantly lower than in the other strains, and the number of oocytes showed a positive correlation with the number of ovarian mast cells. The gene expression of a mast cell marker also correlated with the expression of an oocyte nest marker, suggesting a link between the appearance of ovarian ? 4mast cells and early follicular development. Furthermore, the expression of follicle developmental markers was significantly higher in MRL/MpJ mice than in C57BL/6 mice. These results indicate that the appearance of ovarian mast cells is a unique phenotype of neonatal MRL/MpJ mice, and that ovarian mast cells participate in early follicular development, especially nest breakdown.

show abstract

“…But, other cysts are mostly nonfunctional. The precise causes of these nonfunctional ovarian cysts have not yet been fully elucidated [4,9]. Ovarian cysts in women are often associated with reproductive disorders like polycystic ovary syndrome (PCOS) [6].…”

mentioning

confidence: 99%

Bilateral Ovarian Cysts Originating from Rete Ovarii in an African Green Monkey (<i>Cercopithecus Aethiops</i>)

Kim

Lee

et al. 2012

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

ABSTRACT. Ovarian cyst is common incidental finding in humans and many animals and includes follicular cysts, cystic rete ovarii and mesonephric duct cysts. Ovarian cyst is often associated with reproductive disorders in humans and animals. We found accidentally bilateral cystic masses in ovaries in an African green monkey. Grossly, the left and right ovarian cystic masses were single unilocular cystic structures measuring 0.6 and 1.8 cm in diameter, respectively. Histologically, both cysts were thin-walled structures that arose from the center of the ovary and displaced ovarian tissue peripherally. The cysts were lined by a single layer of nonciliated low cuboidal epithelium. Immunohistochemically, epithelial cells in the cysts were positive for cytokeratin, and the stromal cells were positive for smooth muscle actin but negative for vimentin. These results suggest that these ovarian cysts in an African green monkey are cystic rete ovarii. To our knowledge, this is the first report of cystic rete ovarii in African green monkeys and may be of value in relation to research of the pathogenesis and treatment of ovarian cyst.

show abstract

Quantitative trait locus analysis of ovarian cysts derived from rete ovarii in MRL/MpJ mice

Cited by 6 publications

References 54 publications

Ovarian cysts in MRL / MpJ mice are derived from the extraovarian rete: a developmental study

Ovarian cysts in MRL / MpJ mice are derived from the extraovarian rete: a developmental study

Relationship between Numerous Mast Cells and Early Follicular Development in Neonatal MRL/MpJ Mouse Ovaries

Bilateral Ovarian Cysts Originating from Rete Ovarii in an African Green Monkey (<i>Cercopithecus Aethiops</i>)

Contact Info

Product

Resources

About