Quantitative Trait Loci (QTLs) mapping for growth traits in the mouse: A review

Corva, P. M.; Medrano, Juan F.

doi:10.1051/gse:2001112

Cited by 22 publications

(24 citation statements)

References 35 publications

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“…Many QTLs affecting obese or lean phenotypes have been detected by genetic linkage analysis using various combinations of laboratory mouse strains (Corva and Medrano 2001;Rankinen et al 2006). We anticipated that MSM/Ms would have significantly different metabolic parameters than the B6 strain, because of large genomic divergence and differences in the two strains' histories.…”

Section: Discussionmentioning

confidence: 99%

Mouse inter-subspecific consomic strains for genetic dissection of quantitative complex traits

Takada

Mita²,

Maeno³

et al. 2008

Genome Res.

101

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Consomic strains, also known as chromosome substitution strains, are powerful tools for assigning polygenes that control quantitative complex traits to specific chromosomes. Here, we report generation of a full set of mouse consomic strains, in which each chromosome of the common laboratory strain C57BL/6J (B6) is replaced by its counterpart from the inbred strain MSM/Ms, which is derived from Japanese wild mouse, Mus musculus molossinus. The genome sequence of MSM/Ms is divergent from that of B6, whose genome is predominantly derived from Western European wild mouse, Mus musculus domesticus. MSM/Ms exhibits a number of quantitative complex traits markedly different from those of B6. We systematically determined phenotypes of these inter-subspecific consomic strains, focusing on complex traits related to reproduction, growth, and energy metabolism. We successfully detected more than 200 statistically significant QTLs affecting 26 traits. Furthermore, phenotyping of the consomic strains revealed that the measured values for quantitative complex traits often far exceed the range between B6 host and MSM/Ms donor strains; this may result from segregation of alleles or nonadditive interactions among multiple genes derived from the two mouse subspecies (that is, epistasis). Taken together, the results suggest that the inter-subspecific consomic strains will be very useful for identification of latent genetic components underlying quantitative complex traits.

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Section: Discussionmentioning

confidence: 99%

Mouse inter-subspecific consomic strains for genetic dissection of quantitative complex traits

Takada

Mita²,

Maeno³

et al. 2008

Genome Res.

101

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“…While there have been many molecular quantitative genetic studies of loci affecting growth in mice (see Corva and Medrano, 2001) no existing studies have included the contribution of maternal effect loci, despite their obvious importance in the quantitative genetics of growth. Here we analyze the contribution of maternal effects to the genetics of early developmental traits in mice by characterizing QTL influencing early growth.…”

Section: Introductionmentioning

confidence: 99%

Contribution of maternal effect QTL to genetic architecture of early growth in mice

et al. 2002

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Existing approaches to characterizing quantitative trait loci (QTL) utilize a paradigm explicitly focused on the direct effects of genes, where phenotypic variation among individuals is mapped onto genetic variation of those individuals. For many characters, however, the genotype of the mother via its maternal effect accounts for a considerable portion of the genetically based variation in progeny phenotypes. Thus the focus on direct effect QTL may result in an insufficient or misleading characterization of genetic architecture due to the omission of the potentially important source of genetic variance contributed by maternal effects. We analyze the relative contribution of direct and maternal effect (ME) QTL to early growth in mice using a three-generation intercross of the Small (SM/J) and Large (LG/J) inbred mouse lineages. Using interval mapping and composite interval mapping, direct effect (DE) QTL for early growth (change in body mass during the interval from week 1 to 2) were detected in the F 2 generation of the intercross (n = 510), where no maternal genetic effect variance is present (all individuals are progeny

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“…A recent review [7] lists a number of other studies that have found QTL affecting murine growth on chromosome 6, however none of the estimated locations of these QTL are within the 95% confidence interval of the QTL identified in this study. This target region is less than 7 cM and contains approximately 100 genes according to the Ensembl database [8].…”

Section: Discussionmentioning

confidence: 60%

“…We have identified a QTL affecting body mass on chromosome 6 in an F 2 cross between two lines that have been divergently selected for body weight. Many studies have performed genome-wide scans for body mass QTL [7] and yet relatively few have gone on to replicate findings or to examine the effects of QTL in different genetic backgrounds. We therefore introgressed the sixth chromosome from each of the parental lines into the genetic background of the other parental line, i.e., the 'high' QTL allele into the 'low' background and vice versa.…”

Section: Introductionmentioning

confidence: 99%

Identification and reciprocal introgression of a QTL affecting body mass in mice

et al. 2004

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-The aim of this study was to examine the effects of a QTL in different genetic backgrounds. A QTL affecting body mass on chromosome 6 was identified in an F 2 cross between two lines of mice that have been divergently selected for this trait. The effect of the QTL on mass increased between 6 and 10 weeks of age and was not sex-specific. Body composition analysis showed effects on fat-free dry body mass and fat mass. To examine the effect of this QTL in different genetic backgrounds, the high body mass sixth chromosome was introgressed into the low body mass genetic background and vice versa by repeated marker-assisted backcrossing. After three generations of backcrossing, new F 2 populations were established within each of the introgression lines by crossing individuals that were heterozygous across the sixth chromosome. The estimated additive effect of the QTL on 10-week body mass was similar in both genetic backgrounds and in the original F 2 population (i.e., ∼0.4 phenotypic standard deviations); no evidence of epistatic interaction with the genetic background was found. The 95% confidence interval for the location of the QTL was refined to a region of approximately 7 cM between D6Mit268 and D6Mit123. quantitative trait loci / introgression / epistasis / body mass

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Quantitative Trait Loci (QTLs) mapping for growth traits in the mouse: A review

Cited by 22 publications

References 35 publications

Mouse inter-subspecific consomic strains for genetic dissection of quantitative complex traits

Mouse inter-subspecific consomic strains for genetic dissection of quantitative complex traits

Contribution of maternal effect QTL to genetic architecture of early growth in mice

Identification and reciprocal introgression of a QTL affecting body mass in mice

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