Quantitative Trait Loci for Lipid Content in <i>Drosophila melanogaster</i>

Wang, Mei Hui; Harshman, Lawrence G.; Nuzhdin, Sergey V.

doi:10.1038/oby.2005.232

Cited by 9 publications

(8 citation statements)

References 20 publications

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“…The positive correlation between weight and pupal survival is consistent with the well-documented positive correlation between weight and fitness seen in other insect studies (Honek 1993). A lack of correlation between weight and triglyceride content is consistent with previous findings (Wang et al 2005).…”

Section: Sources Of Phenotypic Variationsupporting

confidence: 81%

Genotype-by-Diet Interactions Drive Metabolic Phenotype Variation inDrosophila melanogaster

et al. 2010

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The rising prevalence of complex disease suggests that alterations to the human environment are increasing the proportion of individuals who exceed a threshold of liability. This might be due either to a global shift in the population mean of underlying contributing traits, or to increased variance of such underlying endophenotypes (such as body weight). To contrast these quantitative genetic mechanisms with respect to weight gain, we have quantified the effect of dietary perturbation on metabolic traits in 146 inbred lines of Drosophila melanogaster and show that genotype-by-diet interactions are pervasive. For several metabolic traits, genotype-by-diet interactions account for far more variance (between 12 and 17%) than diet alone (1-2%), and in some cases have as large an effect as genetics alone (11-23%). Substantial dew point effects were also observed. Larval foraging behavior was found to be a quantitative trait exhibiting significant genetic variation for path length (P ¼ 0.0004). Metabolic and fitness traits exhibited a complex correlation structure, and there was evidence of selection minimizing weight under laboratory conditions. In addition, a high fat diet significantly increases population variance in metabolic phenotypes, suggesting decreased robustness in the face of dietary perturbation. Changes in metabolic trait mean and variance in response to diet indicates that shifts in both population mean and variance in underlying traits could contribute to increases in complex disease.

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Section: Sources Of Phenotypic Variationsupporting

confidence: 81%

Genotype-by-Diet Interactions Drive Metabolic Phenotype Variation inDrosophila melanogaster

et al. 2010

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“…We found here that metabolic pools of carbohydrates, lipids and protein slightly differ in young flies of both sexes what in general correspond to other studies (Wang et al, 2005;Matzkin et al, 2011;Parisi et al, 2011). However, this study shows that response of antioxidant system to dietary sucrose in Drosophila substantially depended on fly sex.…”

Section: Sex-specific Metabolic and Antioxidant Response To Dietary Ssupporting

confidence: 61%

High sucrose consumption promotes obesity whereas its low consumption induces oxidative stress in Drosophila melanogaster

Rovenko

Kubrak

Gospodaryov

et al. 2015

Journal of Insect Physiology

102

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“…However, no such clinal variations were evident for SR in South American populations of D. melanogaster (Robinson et al, 2000). Further, P-element analysis has suggested that the candidate genes involved in SR showed sex-specific effects on the phenotype (Harbison et al, 2005;Wang et al, 2005). Consequently, sexes might have asserted variable levels of adaptation to starvation stress under similar evolutionary forces, which might have resulted in sexual dimorphism in clinal patterns of SR.…”

Section: Discussionmentioning

confidence: 99%

Physiological basis of starvation resistance inDrosophila leontia: analysis of sexual dimorphism

Aggarwal

2014

Journal of Experimental Biology

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Geographically varying starvation stress has often been considered as a natural selector that constrains between-population differences for starvation resistance (SR) in Drosophila species. On the Indian subcontinent, a dozen Drosophila species have shown clinal variations in SR across latitude, but the evolved physiological basis of such contrasting adaptations is largely unknown. In the present study, I untangled the physiological basis of sex-specific as well as between-population divergence for SR in D. leontia, collected across a latitudinal transect of the Indian subcontinent (11°45′-31°19′N). Secondly, I tested the assumptions that hardening to starvation stress facilitates an increased survival under subsequent lethal levels of starvation, and such plastic effects differ between the sexes. I observed several interesting results. In contrast to a steeper cline of starvation-related traits with latitude in females, a shallower gradient was observed for males. Females stored higher (~1.3-fold) dry-massspecific levels of body lipids and glycogen contents, and utilized these both of these energy resources under starvation stress, whereas the starved males metabolized only body lipids as a source of energy. Conversely, the rate of body lipid utilization and threshold need were considerably higher in females as compared with males. Betweenpopulation differences were significant for storage levels of energy reserves only, but not for other avenues (rate of metabolite utilization and threshold need) of SR for both sexes. These findings indicate that multiple pathways shape the physiological basis of sexual dimorphism for SR in D. leontia. Further, single or multiple bouts of starvation hardening conferred an increased longevity (~4-9 h; P<0.001) under subsequent lethal levels of starvation stress for females only, and such plastic responses were consistent with a decrease in rate of metabolite utilization. Nevertheless, between-population effects were non-significant for absolute hardening capacity (AHC=K SR -C). Altogether, these findings suggest that similar evolutionary constraints have resulted in divergent genetic as well as plastic responses to evolve adaptations under starvation stress, and account for the observed sexual dimorphism for basal SR in D. leontia.

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Quantitative Trait Loci for Lipid Content in Drosophila melanogaster

Cited by 9 publications

References 20 publications

Genotype-by-Diet Interactions Drive Metabolic Phenotype Variation inDrosophila melanogaster

Genotype-by-Diet Interactions Drive Metabolic Phenotype Variation inDrosophila melanogaster

High sucrose consumption promotes obesity whereas its low consumption induces oxidative stress in Drosophila melanogaster

Physiological basis of starvation resistance inDrosophila leontia: analysis of sexual dimorphism

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