Quantitative trait loci associated with body weight and abdominal fat traits on chicken chromosomes 3, 5 and 7

Wang, S Z; Hu, Xingwang; Wang, Z P; Li, X C; Wang, Q G; Wang, Y X; Tang, Zhijie; Li, H

doi:10.4238/2012.april.19.1

Cited by 44 publications

(33 citation statements)

References 35 publications

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“…By 2001, however, chicken producers could rear chickens to their final body weight of 2.5 kg in a fattening period of only 42 days (Havenstein et al, 2003; Flock et al, 2005). Chickens have been genetically improved for increased body weight gain, feed efficiency, growth rate, and breast muscle weight to meet the requirements of consumers (Wang et al, 2012). These selection processes have produced modern commercial chicken lines with a higher growth rate, breast meat yield and better feed conversion rates, and a higher body fat compared with unselected lines (Baéza and Le Bihan-Duval, 2013).…”

Section: Introductionmentioning

confidence: 99%

Nutritional Factors Affecting Abdominal Fat Deposition in Poultry: A Review

Fouad¹,

El-Senousey²

2014

Asian Australas. J. Anim. Sci

210

147

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The major goals of the poultry industry are to increase the carcass yield and to reduce carcass fatness, mainly the abdominal fat pad. The increase in poultry meat consumption has guided the selection process toward fast-growing broilers with a reduced feed conversion ratio. Intensive selection has led to great improvements in economic traits such as body weight gain, feed efficiency, and breast yield to meet the demands of consumers, but modern commercial chickens exhibit excessive fat accumulation in the abdomen area. However, dietary composition and feeding strategies may offer practical and efficient solutions for reducing body fat deposition in modern poultry strains. Thus, the regulation of lipid metabolism to reduce the abdominal fat content based on dietary composition and feeding strategy, as well as elucidating their effects on the key enzymes associated with lipid metabolism, could facilitate the production of lean meat and help to understand the fat-lowering effects of diet and different feeding strategies.

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Section: Introductionmentioning

confidence: 99%

Nutritional Factors Affecting Abdominal Fat Deposition in Poultry: A Review

Fouad¹,

El-Senousey²

2014

Asian Australas. J. Anim. Sci

210

147

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“…Szapacs et al [34] showed that when APOA1 was exposed to oxidative changes, the formation of HDL and its exportation to the liver were altered. In chicken, GGA7, which is homoeologous to APL7, carries numerous QTL related to abdominal fat [35, 36]. Taken together, these results strengthen the hypothesis that chromosome APL7 is important in “fat” metabolism and further studies will be required to identify the genes that underlie the QTL and pQTL mapped to this chromosome.…”

Section: Discussionmentioning

confidence: 69%

Deciphering mechanisms underlying the genetic variation of general production and liver quality traits in the overfed mule duck by pQTL analyses

et al. 2017

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BackgroundThe aim of this study was to analyse the mechanisms that underlie phenotypic quantitative trait loci (QTL) in overfed mule ducks by identifying co-localized proteomic QTL (pQTL). The QTL design consisted of three families of common ducks that were progeny-tested by using 294 male mule ducks. This population of common ducks was genotyped using a genetic map that included 334 genetic markers located across 28 APL chromosomes (APL for Anas platyrhynchos). Mule ducks were phenotyped for 49 traits related to growth, metabolism, overfeeding ability and meat and fatty liver quality, and 326 soluble fatty liver proteins were quantified.ResultsOne hundred and seventy-six pQTL and 80 phenotypic QTL were detected at the 5% chromosome-wide significance threshold. The great majority of the identified pQTL were trans-acting and localized on a chromosome other than that carrying the coding gene. The most significant pQTL (1% genome-wide significance) were found for alpha-enolase on APL18 and fatty acid synthase on APL24. Some proteins were associated with numerous pQTL (for example, 17 and 14 pQTL were detected for alpha-enolase and apolipoprotein A1, respectively) and pQTL hotspots were observed on some chromosomes (APL18, 24, 25 and 29). We detected 66 co-localized phenotypic QTL and pQTL for which the significance of the two-trait QTL (2t-QTL) analysis was higher than that of the strongest QTL using a single-trait approach. Among these, 16 2t-QTL were pleiotropic. For example, on APL15, melting rate and abundance of two alpha-enolase spots appeared to be impacted by a single locus that is involved in the glycolytic process. On APLZ, we identified a pleiotropic QTL that modified both the blood level of glucose at the beginning of the force-feeding period and the concentration of glutamate dehydrogenase, which, in humans, is involved in increased glucose absorption by the liver when the glutamate dehydrogenase 1 gene is mutated.ConclusionsWe identified pleiotropic loci that affect metabolic pathways linked to glycolysis or lipogenesis, and in the end to fatty liver quality. Further investigation, via transcriptomics and metabolomics approaches, is required to confirm the biomarkers that were found to impact the genetic variability of these phenotypic traits.Electronic supplementary materialThe online version of this article (doi:10.1186/s12711-017-0313-6) contains supplementary material, which is available to authorized users.

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“…Therefore, studies on the chicken genome have been of great value to both agriculture and medicine (Wang et al, 2012a). Therefore, studies on the chicken genome have been of great value to both agriculture and medicine (Wang et al, 2012a).…”

Section: Introductionmentioning

confidence: 99%

Quantitative trait loci and candidate genes for the economic traits in meat-type chicken

Cahyadi

Lee

2014

World's Poultry Science Journal

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Recent progress has been achieved in the identification of quantitative trait loci (QTLs) and candidate genes, and they have been found to be very important for the production of chickens with more desirable meat characteristics. The major economic traits of chicken meat production were divided into two major categories, namely growth and carcass condition. In this paper, the QTL locations and candidate genes for the above mentioned traits are reviewed. The results presented here will provide guidelines for the selection of high quality and highly productive chickens through the marker assisted selection (MAS), which should be extensively used by poultry breeders and companies.

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Quantitative trait loci associated with body weight and abdominal fat traits on chicken chromosomes 3, 5 and 7

Cited by 44 publications

References 35 publications

Nutritional Factors Affecting Abdominal Fat Deposition in Poultry: A Review

Nutritional Factors Affecting Abdominal Fat Deposition in Poultry: A Review

Deciphering mechanisms underlying the genetic variation of general production and liver quality traits in the overfed mule duck by pQTL analyses

Quantitative trait loci and candidate genes for the economic traits in meat-type chicken

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