Quantitative, titratable and high-throughput reporter assays to measure DNA double strand break repair activity in cells
Eeson Rajendra,
Diego Grande,
Bethany Mason
et al.
Abstract:Repair of DNA damage is essential for the maintenance of genome stability and cell viability. DNA double strand breaks (DSBs) constitute a toxic class of DNA lesion and multiple cellular pathways exist to mediate their repair. Robust and titratable assays of cellular DSB repair (DSBR) are important to functionally interrogate the integrity and efficiency of these mechanisms in disease models as well as in response to genetic or pharmacological perturbations. Several variants of DSBR reporters are available, ho… Show more
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