Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia

Fulci, Valerio; Chiaretti, Sabina; Goldoni, Marina; Azzalin, Gianluca; Carucci, Nicoletta; Tavolaro, Simona; Castellano, Leandro; Magrelli, Armando; Citarella, Franca; Messina, Monica; Maggio, Roberta; Peragine, Nadia; Santangelo, Simona; Mauro, Francesca Romana; Landgraf, Pablo; Tuschl, Thomas; Weir, David B.; Chien, Minchen; Russo, James J.; Ju, Jingyue; Sheridan, Robert P.; Sander, Chris; Zavolan, Mihaela; Guarini, Anna; Foà, Robin; Macino, Giuseppe

doi:10.1182/blood-2006-12-062398

Cited by 460 publications

(381 citation statements)

References 44 publications

(55 reference statements)

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“…Under pathologic conditions, miR-155 has been associated with a number of human neoplastic disorders. Studies have shown that miR-155 accumulates in chronic lymphocytic leukemia (34), lymphomas (30,35), breast cancer, and pancreatic cancer (36,37). Our findings extend the information on miR-155 expression in human cells by demonstrating its presence in synovial fibroblasts.…”

Section: Discussionsupporting

confidence: 81%

Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis

Stańczyk

Pedrioli

Brentano

et al. 2008

Arthritis & Rheumatism

743

617

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Objective. MicroRNAs (miRNA) have recently emerged as a new class of modulators of gene expression. In this study we investigated the expression, regulation, and function of miR-155 and miR-146a in rheumatoid arthritis (RA) synovial fibroblasts (RASFs) and RA synovial tissue.Methods. Locked nucleic acid microarray was used to screen for differentially expressed miRNA in RASFs treated with tumor necrosis factor ␣ (TNF␣). TaqMan-based real-time polymerase chain reaction was applied to measure the levels of miR-155 and miR-146a. Enforced overexpression of miR-155 was used to investigate the function of miR-155 in RASFs.Results

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Section: Discussionsupporting

confidence: 81%

Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis

Stańczyk

Pedrioli

Brentano

et al. 2008

Arthritis & Rheumatism

743

617

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“…Dysregulation of miRNA expression has been identified in a number of cancers (Pan et al, 2001;Lu et al, 2005;Volinia et al, 2006;Blenkiron et al, 2007;Chen and Stallings, 2007;Fulci et al, 2007;Gaur et al, 2007;Kummar et al, 2007;Meng et al, 2007;Porkka et al, 2007;Wedel et al, 2008) and an accumulating data indicate that some miRNAs can function as tumor suppressors or oncogenes and are important in cancer development. Deletion or loss of function of a tumor-suppressing miRNA results in overexpression of target oncogenes.…”

Section: Introductionmentioning

confidence: 99%

miR-449a targets HDAC-1 and induces growth arrest in prostate cancer

et al. 2009

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“…It is also reported to be up-regulated in hematological malignancies such as leukemia[2], lymphoma[3], and multiple myeloma[4]. miR-21 is overexpressed in glioblastoma[5], osteosarcoma [6], and spermatocytic seminoma[7].…”

mentioning

confidence: 99%

Apoptosis and the target genes of microRNA-21

Buscaglia¹,

Yong²

2011

Chin J Cancer

216

180

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MicroRNA-21 (miR-21) is frequently up-regulated in cancer and the majority of its reported targets are tumor suppressors. Through functional suppression, miR-21 is implicated in practically every walk of oncogenic life: the promotion of cell proliferation, invasion and metastasis, genome instability and mutation, inflammation, replicative immortalization, abnormal metabolism, angiogenesis, and evading apoptosis, immune destruction, and growth suppressors. In particular, miR-21 is strongly involved in apoptosis. In this article, we reviewed the experimentally validated targets of miR-21 and found that two thirds are linked to intrinsic and/or extrinsic pathways of cellular apoptosis. This suggests that miR-21 is an Oncogene which plays a key role in resisting programmed cell death in cancer cells and that targeting apoptosis is a viable therapeutic option against cancers expressing miR-21.

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Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia

Cited by 460 publications

References 44 publications

Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis

Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis

miR-449a targets HDAC-1 and induces growth arrest in prostate cancer

Apoptosis and the target genes of microRNA-21

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