Quantitative T2 evaluation at 3.0 T compared to morphological grading of the lumbar intervertebral disc: A standardized evaluation approach in patients with low back pain

Stelzeneder, David; Welsch, Goetz H.; Kovács, Balazs; Goed, Sabine; Paternostro-Sluga, Tatjana; Vlychou, Marianna; Friedrich, Klaus; Mamisch, Tallal C.; Trattnig, Siegfried

doi:10.1016/j.ejrad.2010.12.093

Cited by 77 publications

(96 citation statements)

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“…9,28,29 For the AF T2, our results were similar to those of Stelzeneder et al 28 and Welsch et al, 29 and slightly higher than those of Trattnig et al 9 With respect to the T1 relaxation times, the values encountered for the NP and AF in our study were lower than those found in the literature. 12,[30][31][32] We hypothesize that at least in part, this difference may be due to different magnetic field strengths, because most of the previous studies used 3T MR imaging.…”

Section: Discussioncontrasting

confidence: 53%

“…For practical reasons, most previous studies have used small geometric ROIs for degenerative disk disease. 9, 15 We did not find any previous study in vivo that explored the segmentation of the intervertebral disk to its full extent.…”

Section: Discussionmentioning

confidence: 67%

“…However, the comparison among results of different studies that used different segmentation methods should be done with caution. 15,27 Our results demonstrate that the use of different segmentation techniques may result in measurement of different values of intervertebral disk relaxation times.…”

Section: Discussionmentioning

confidence: 88%

“…20 Thus, in degenerated disks, the relaxation time of NP became very close to that of AF because the disk composition becomes more homogeneous. 15,21 In cases of severe scoliosis, disk degeneration may occur unevenly in different regions of the disk. [22][23][24] The presence of volunteers with scoliosis could potentially affect our results of comparison between different segmentation techniques, but it did not occur because we had no case of scoliosis.…”

Section: Discussionmentioning

confidence: 99%

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T1ρ and T2 Mapping of the Intervertebral Disk: Comparison of Different Methods of Segmentation

Reis¹,

Salmon

Carvalho³

et al. 2014

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Intervertebral disk biochemical composition could be accessed in vivo by T1 and T2 relaxometry. We found no studies in the literature comparing different segmentation methods for data extraction using these techniques. Our aim was to compare different manual segmentation methods used to extract T1 and T2 relaxation times of intervertebral disks from MR imaging. Seven different methods of partial-disk segmentation techniques were compared with whole-disk segmentation as the reference standard.

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Section: Discussioncontrasting

confidence: 53%

Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

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T1ρ and T2 Mapping of the Intervertebral Disk: Comparison of Different Methods of Segmentation

Reis¹,

Salmon

Carvalho³

et al. 2014

AJNR Am J Neuroradiol

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“…Qualitative grading of IVD degeneration is confined by subjective interpretation and limit degeneration classification to non-continuous grades. MRI sequences, enabling direct quantification of T1q and T2 relaxation time, have been developed and have showed promise for tissue characterization of the IVD [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

MRI histogram analysis enables objective and continuous classification of intervertebral disc degeneration

et al. 2017

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Purpose Magnetic resonance imaging (MRI) is the best diagnostic imaging method for low back pain. However, the technique is currently not utilized in its full capacity, often failing to depict painful intervertebral discs (IVDs), potentially due to the rough degeneration classification system used clinically today. MR image histograms, which reflect the IVD heterogeneity, may offer sensitive imaging biomarkers for IVD degeneration classification. This study investigates the feasibility of using histogram analysis as means of objective and continuous grading of IVD degeneration. Methods Forty-nine IVDs in ten low back pain patients (six males, 25-69 years) were examined with MRI (T2-weighted images and T2-maps). Each IVD was semi-automatically segmented on three mid-sagittal slices. Histogram features of the IVD were extracted from the defined regions of interest and correlated to Pfirrmann grade. Results Both T2-weighted images and T2-maps displayed similar histogram features. Histograms of well-hydrated IVDs displayed two separate peaks, representing annulus fibrosus and nucleus pulposus. Degenerated IVDs displayed decreased peak separation, where the separation was shown to correlate strongly with Pfirrmann grade (P \ 0.05). In addition, some degenerated IVDs within the same Pfirrmann grade displayed diametrically different histogram appearances. Conclusions Histogram features correlated well with IVD degeneration, suggesting that IVD histogram analysis is a suitable tool for objective and continuous IVD degeneration classification. As histogram analysis revealed IVD heterogeneity, it may be a clinical tool for characterization of regional IVD degeneration effects. To elucidate the usefulness of histogram analysis in patient management, IVD histogram features between asymptomatic and symptomatic individuals needs to be compared.

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Marital Status and Outcome of Patients Presenting with Acute Coronary Syndrome: An Observational Report

Khafaji

Habib

Asaad

et al. 2012

Clinical Cardiology

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Background & hypothesis:Data on the clinical characteristics and outcome of patients presenting with acute coronary syndrome (ACS) according to their marital status is not clear.Methods:A total of 5334 patients presenting with ACS in 65 hospitals in 6 Middle East countries in the 2nd Gulf Registry of Acute Coronary Events (Gulf RACE‐2) were studied according to their marital status (5024 married, 100 single, and 210 widowed patients).Result:When compared to married patients, widowed patients were older and more likely to be female. Widowed patients were more likely to have diabetes mellitus, hypertension, history of heart failure, and peripheral vascular disease and were less likely to be tobacco users when compared to the other groups. Widowed patients were also more likely to present with atypical symptoms and have advanced Killip class. Widowed patients were more likely to present with non‐ST‐elevation myocardial infarction (NSTEMI) when compared to the other 2 groups. Widowed patients were more likely to have heart failure (P = 0.001), cardiogenic shock (P = 0.001), and major bleeding (P = 0.002) when compared to the other groups. No statistically significant difference was observed in regard to duration of hospital stay, door to needle time in STEMI patients, or cardiac arrhythmias between the various groups. Widowed patients had higher in‐hospital, 30‐day, and 1‐year mortality rates (P = 0.001). Marital status was an independent predictor for in‐hospital mortality.Conclusion:Widowed marital status was associated with worse cardiovascular risk profile, and worse in‐hospital and 1‐year outcome. Future work should be focused on whether the provision of psychosocial support will result in improved outcomes among this high‐risk group. Clin. Cardiol. 2011 DOI: 10.1002/clc.22034Gulf RACE is a Gulf Heart Association (GHA) project and was financially supported by the GHA, Sanofi Aventis, and the College of Medicine Research Center at King Khalid University Hospital, King Saud University, and Riyadh, Saudi Arabia.The authors have no other funding, financial relationships, or conflicts of interest to disclose.

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Quantitative T2 evaluation at 3.0 T compared to morphological grading of the lumbar intervertebral disc: A standardized evaluation approach in patients with low back pain

Cited by 77 publications

References 18 publications

T1ρ and T2 Mapping of the Intervertebral Disk: Comparison of Different Methods of Segmentation

T1ρ and T2 Mapping of the Intervertebral Disk: Comparison of Different Methods of Segmentation

MRI histogram analysis enables objective and continuous classification of intervertebral disc degeneration

Marital Status and Outcome of Patients Presenting with Acute Coronary Syndrome: An Observational Report

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