Quantitative systems pharmacology modeling of tumor heterogeneity in response to BH3‐mimetics using virtual tumors calibrated with cell viability assays
Thibaud Derippe,
Sylvain Fouliard,
Xavier Decleves
et al.
Abstract:Both primary and acquired resistance mechanisms that involve intra‐tumoral cell heterogeneity limit the use of BH3‐mimetics to trigger tumor cell apoptosis. This article proposes a new quantitative systems pharmacology (QSP)‐based methodology in which cell viability assays are used to calibrate virtual tumors (VTs) made of virtual cells whose fate is determined by simulations from an apoptosis QSP model. VTs representing SU‐DHL‐4 and KARPAS‐422 cell lines were calibrated using in vitro data involving venetocla… Show more
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