Quantitative Swept-Source Optical Coherence Tomography of Early Enamel Erosion in vivo

Austin, Rupert; Taha, Maisalamah Haji; Festy, Frederic; Cook, Richard; Andiappan, Manoharan; Gómez, Juliana; Pretty, Iain A.; Moazzez, Rebecca

doi:10.1159/000477098

Cited by 14 publications

(12 citation statements)

References 27 publications

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“…Austin et al . proposed an analysis method for evaluating the influence on the OCT backscattered intensity of enamel surface due to orange juice rinsing 29 . Habib et al .…”

Section: Introductionmentioning

confidence: 99%

Early detection of enamel demineralization by optical coherence tomography

Tsai

Wang

Yeh

et al. 2019

Sci Rep

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Enamel is the outermost layer of the tooth that protects it from invasion. In general, an acidic environment accelerates tooth demineralization, leading to the formation of cavities. Scanning electron microscopy (SEM) is conventionally used as an in vitro tool for the observation of tooth morphology changes with acid attacks. Yet, SEM has intrinsic limitations for the potential application of in vivo detection in the early demineralization process. In this study, a high-resolution optical coherence tomography (OCT) system with the axial and transverse resolutions of 2.0 and 2.7 μm in teeth has been utilized for characterizing the effect of the acidic environment (simulated by phosphoric acid) on the enamel topology. The scattering coefficient and the surface roughness of enamel can be directly derived from the OCT results, enabling a quantitative evaluation of the topology changes with demineralization. The dynamic process induced by the acid application is also recorded and analyzed with OCT, depicting the evolution of the demineralization process on enamel. Notably, the estimated enamel scattering coefficient and surface roughness significantly increase with the application time of acid and the results illustrate that the values of both parameters after demineralization are significantly larger than those obtained before the demineralization, illustrating both parameters could be effective to differentiate the healthy and demineralized teeth and determine the severity. The obtained results unambiguously illustrate that demineralization of the tooth surface can be successfully detected by OCT and further used as an indicator of early-stage cavity formation.

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“…Austin et al . proposed an analysis method for evaluating the influence on the OCT backscattered intensity of enamel surface due to orange juice rinsing 29 . Habib et al .…”

Section: Introductionmentioning

confidence: 99%

Early detection of enamel demineralization by optical coherence tomography

Tsai

Wang

Yeh

et al. 2019

Sci Rep

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show abstract

“…However, this approach uses a polishing step which removes the outer mineral rich layer. To determine the presence and subsequent progression of these natural surface erosion lesions, changes in surface form, surface roughness, and surface optical properties have been studied previously [18,[21][22][23][24][25].…”

Section: Discussionmentioning

confidence: 99%

Surface form analysis on complex freeform organic structures – measuring erosive wear on human teeth in vitro

Mylonas

Moazzez

Joiner

et al. 2021

Surf. Topogr.: Metrol. Prop.

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Natural human enamel (NHE) is a complex freeform surface which has presented significant difficulties in measuring surface form change using non-contacting laser profilometry (NCLP). Measuring surface form change on NHE is a metrology proxy for measuring dental tooth structure loss, and characterising this using non-ISO parameters (volume, surface area, and normalised lesion depth) has been seldom studied due surface complexity and undetermined measurement errors. This study determines NCLP measurement errors (instrument repeatability and method reproducibility) for non-ISO parameters, characterises change in surface form on NHE following a dietary pH-cycling model. NHE (n = 1) was scanned consecutively twenty-times using NCLP with/without sample replacement producing consecutive surface profile data. Residual data was created after subtracting consecutive filtered profile data (80 μm, Gaussian filter), and mean (SD) volume, surface area, and normalised lesion depth was determined within a 1.5 mm circular region of interest (ROI). Volume error (expressed as height variation across ROI surface area) was 0.022 μm (instrument repeatability) and 0.149 μm (method reproducibility), whilst surface area error (expressed as percentage change of the surface area deviation across the entire surface area) was 0.034% (repeatability error) and 0.081% (reproducibility error). Sixty-four natural enamel surfaces taped with polyvinyl-chloride tape leaving 1.5 mm exposed ROI underwent dietary erosion cycling (three 5-min cycles, 0.3% citric acid w/v, pH 3.2) generating artificial erosion lesions. Samples were scanned with NCLP before/after each erosion cycle, scans filtered for microtexture, and after-erosion scans were subtracted from beforeerosion scans. NCLP results show mean (SD) volume, surface area, normalised depth, and 3D stepheight of the eroded area increased significantly after each erosion cycle, with no significant difference in calcium and phosphate release after each cycle. We demonstrate a robust and valid dental model with analysis workflow to measure surface form change in NHE using NCLP, improving understanding of measuring surface form change in complex freeform surfaces.

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“…The number of several OCT studies already demonstrated in dentistry that OCT can be used to nondestructively measure the severity of the lesion in enamel with cross-polarization optical coherence tomography (CP-OCT), swept-source optical coherence tomography (SS-OCT) images 6,[11][12][13] . The principal purpose of this study was to demonstrate the efficacy of different remineralization agents on artificial lesions using the high-definition (HD) spectral-domain optical coherence tomography (SD-OCT) and to compare it with the surface microhardness (SMH) analysis.…”

Section: Introductionmentioning

confidence: 99%

Comparative evaluation of the spectral-domain optical coherence tomography and microhardness for remineralization of enamel caries lesions

Yavuz

Kargül

2021

Dent. Mater. J.

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This study aimed to evaluate the Cirrus high-definition (HD) spectral-domain optical coherence tomography (SD-OCT) for the remineralization of artificial enamel caries and to compare it with the comparison surface microhardness (SMH) analysis. Artificial caries lesions were produced on forty human enamel samples. Then, three different remineralization agents containing casein phosphopeptide amorphous calcium phosphate; casein phosphopeptide amorphous calcium fluoride phosphate; calcium glycerophosphate, magnesium chloride, and xylitol; and remineralization solution (control) were applied with pH cycling for six days. The optical depth of backscattered light and microhardness of enamel were measured using SD-OCT and SMH. All remineralization agents were significantly efficient in reducing optical lesion depth on enamels (p1=0.001, p2=0.002, p3=0.006, p4=0.025), and in increasing the SMH of enamels (p1−3=0.005, p4=0.017). However, the optical lesion depths of the enamel showed no correlation with the SMH in the groups. In conclusion, demineralization and remineralization of artificial lesions can be assessed with both SD-OCT and SMH.

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Quantitative Swept-Source Optical Coherence Tomography of Early Enamel Erosion in vivo

Cited by 14 publications

References 27 publications

Early detection of enamel demineralization by optical coherence tomography

Early detection of enamel demineralization by optical coherence tomography

Surface form analysis on complex freeform organic structures – measuring erosive wear on human teeth in vitro

Comparative evaluation of the spectral-domain optical coherence tomography and microhardness for remineralization of enamel caries lesions

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