Quantitative Susceptibility Mapping: Technical Considerations and Clinical Applications in Neuroimaging

Vinayagamani, S.; Sheelakumari, R; Sabarish, Sekar; Senthilvelan, Santhakumar; Ros, Roopa; Kesavadas, Chandrasekharan

doi:10.1002/jmri.27058

Cited by 44 publications

(48 citation statements)

References 85 publications

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“…Quantitative susceptibility mapping (QSM)-based techniques allow whole-brain absolute CMRO 2 measurement without gas manipulation. [69][70][71][72] While QSM has the potential to provide neuroimaging biomarkers in various neurodegenerative disorders, 73 few studies have applied it to dynamically measure absolute CMRO 2 changes during cognitive tasks, likely due to the relatively lengthy scan time. Recently, our group developed a gas-free MRI technique to dynamically measure the whole-brain oxygen extraction fraction with improved temporal resolution.…”

Section: Discussionmentioning

confidence: 99%

Impaired cerebral vascular and metabolic responses to parametric N-back tasks in subjective cognitive decline

Zhang

Yin

et al. 2021

J Cereb Blood Flow Metab

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Previous studies reported abnormally increased and/or decreased blood oxygen level-dependent (BOLD) activations during functional tasks in subjective cognitive decline (SCD). The neurophysiological basis underlying these functional aberrations remains debated. This study aims to investigate vascular and metabolic responses and their dependence on cognitive processing loads during functional tasks in SCD. Twenty-one SCD and 18 control subjects performed parametric N-back working-memory tasks during MRI scans. Task-evoked percentage changes (denoted as δ) in cerebral blood volume (δCBV), cerebral blood flow (δCBF), BOLD signal (δBOLD) and cerebral metabolic rate of oxygen (δCMRO2) were evaluated. In the frontal lobe, trends of decreased δCBV, δCBF and δCMRO2 and increased δBOLD were observed in SCD compared with control subjects under lower loads, and these trends increased to significant differences under the 3-back load. δCBF was significantly correlated with δCMRO2 in controls, but not in SCD subjects. As N-back loads increased, the differences between SCD and control subjects in δCBF and δCMRO2 tended to enlarge. In the parietal lobe, no significant between-group difference was observed. Our findings suggested that impaired vascular and metabolic responses to functional tasks occurred in the frontal lobe of SCD, which contributed to unusual BOLD hyperactivation and was modulated by cognitive processing loads.

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Section: Discussionmentioning

confidence: 99%

Impaired cerebral vascular and metabolic responses to parametric N-back tasks in subjective cognitive decline

Zhang

Yin

et al. 2021

J Cereb Blood Flow Metab

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“…Further research using a quantitative susceptibility mapping technique would allow for quantitative analysis of the OEF and accurate determination of the extent of the PVS. 27 , 28 If volumetric analysis is feasible, the SWI-DWI mismatch ratio could be calculated and the relationship between the PVS and collateral circulation could be more accurately delineated.…”

Section: Discussionmentioning

confidence: 99%

Susceptibility-diffusion mismatch correlated with leptomeningeal collateralization in large vessel occlusion stroke

Jiang

Zhang²,

Pang

et al. 2021

J Int Med Res

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Objective To investigate the relationship between asymmetric prominent hypointense vessels (prominent vessel sign, PVS) on susceptibility-weighted imaging (SWI) and leptomeningeal collateralization in patients with acute ischemic stroke due to large vessel occlusion. Methods We retrospectively enrolled patients with M1 segment occlusion of the middle cerebral artery who underwent emergency magnetic resonance imaging and digital subtraction angiography within 24 hours from stroke onset. The extent of PVS on SWI was assessed using the Alberta Stroke Program Early CT Score (ASPECTS). Leptomeningeal collateralization on digital subtraction angiography images was assessed using the American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology (ASITN/SIR) scale. Spearman’s rank correlation test was performed to explore the correlation of ASITN/SIR scores with SWI-ASPECTS and SWI-diffusion-weighted imaging (DWI) mismatch scores. Results Thirty-five patients were enrolled. There was no significant correlation between SWI-ASPECTS and ASITN/SIR scores. However, SWI-DWI mismatch scores were positively correlated with ASITN/SIR scores. Conclusion The range of PVS on SWI did not closely reflect the collateral status, while the range of SWI-DWI mismatch was significantly correlated with the leptomeningeal collateralization. In patients with acute anterior circulation stroke due to large vessel occlusion, larger SWI-DWI mismatch was associated with better leptomeningeal collaterals.

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“…This method is referred to as calculation of susceptibility through multiple orientation sampling, or COSMOS [ 196 ], and is regarded as the golden standard for QSM. This requires, however, long acquisition times and the assumption of isotropic magnetic susceptibility, thereby making this technique impractical for in vivo measurements [ 193 , 197 ]. Therefore, regularization approaches using prior information to determine a unique solution from a single acquisition are used.…”

Section: Cerebral Perfusion Mri Techniquesmentioning

confidence: 99%

“…The ratio of blood oxygen defined as the Oxygen Extraction Fraction (OEF) can be obtained by calculating the difference between the susceptibility in the veins and tissue ( Table 2 ). Additionally, when used in combination with other MRI sequences that provides a measure of the CBF, QSM can provide a completely non-invasive quantitative measurement of CMRO 2 ( Table 2 ) [ 197 ]. QSM can provide important complementary information to other perfusion MRI techniques and has high potential to be used as an early biomarker for small changes in the cerebral physiology [ 197 ].…”

Section: Cerebral Perfusion Mri Techniquesmentioning

confidence: 99%

Non-Invasive Evaluation of Cerebral Microvasculature Using Pre-Clinical MRI: Principles, Advantages and Limitations

2021

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Alterations to the cerebral microcirculation have been recognized to play a crucial role in the development of neurodegenerative disorders. However, the exact role of the microvascular alterations in the pathophysiological mechanisms often remains poorly understood. The early detection of changes in microcirculation and cerebral blood flow (CBF) can be used to get a better understanding of underlying disease mechanisms. This could be an important step towards the development of new treatment approaches. Animal models allow for the study of the disease mechanism at several stages of development, before the onset of clinical symptoms, and the verification with invasive imaging techniques. Specifically, pre-clinical magnetic resonance imaging (MRI) is an important tool for the development and validation of MRI sequences under clinically relevant conditions. This article reviews MRI strategies providing indirect non-invasive measurements of microvascular changes in the rodent brain that can be used for early detection and characterization of neurodegenerative disorders. The perfusion MRI techniques: Dynamic Contrast Enhanced (DCE), Dynamic Susceptibility Contrast Enhanced (DSC) and Arterial Spin Labeling (ASL), will be discussed, followed by less established imaging strategies used to analyze the cerebral microcirculation: Intravoxel Incoherent Motion (IVIM), Vascular Space Occupancy (VASO), Steady-State Susceptibility Contrast (SSC), Vessel size imaging, SAGE-based DSC, Phase Contrast Flow (PC) Quantitative Susceptibility Mapping (QSM) and quantitative Blood-Oxygenation-Level-Dependent (qBOLD). We will emphasize the advantages and limitations of each strategy, in particular on applications for high-field MRI in the rodent’s brain.

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Quantitative Susceptibility Mapping: Technical Considerations and Clinical Applications in Neuroimaging

Cited by 44 publications

References 85 publications

Impaired cerebral vascular and metabolic responses to parametric N-back tasks in subjective cognitive decline

Impaired cerebral vascular and metabolic responses to parametric N-back tasks in subjective cognitive decline

Susceptibility-diffusion mismatch correlated with leptomeningeal collateralization in large vessel occlusion stroke

Non-Invasive Evaluation of Cerebral Microvasculature Using Pre-Clinical MRI: Principles, Advantages and Limitations

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