“…Because the present custom-made masticatory simulator was also designed to possess a range of adjustable features, including magnitude of loading/chewing force and chewing frequency, the role of a wide range of clinically relevant parameters in the force characteristics on new dental materials can be tested under the most mimicking condition of complex intra-oral masticatory forces. For example, it is possible to determine the effect of forces, from physiologic chewing forces of 10-120 N 18,[26][27][28] to more excessive parafunctional bite forces associated with bruxism and clenching of approximately 200-800 N 15,29) , on fracture resistance of a material of interest. However, a number of other factors, such as moisture, temperature and pH, also influence the mechanical properties and behavior of materials in the oral cavity 30,31) .…”