Quantitative Studies of the Rate of Passage of Protein and Other Nitrogenous Substances Through the Walls of Growing and of Mature Mammalian Blood Capillaries

Abell, Richard G.

doi:10.1097/00000441-193912000-00024

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“…The components are arterioles, precapillary sphincters, capillaries, postcapiUary venules, and muscular venules. Although this class of vessel is the smallest in size, it forms an active barrier between circulating vascular components and tissues, and it represents thousands of miles of tissue surface area [30]. The exchange of gases, nutrients, and metabolic waste between tissues and blood, as well as the interactions of leukocytes or tumor cells with vascular endothelium, occurs primarily within capillary luminae (for reviews see refs.…”

Section: Morphology and Structural Diversity Of Blood Microvesselsmentioning

confidence: 99%

Microvascular endothelial cell heterogeneity: Interactions with leukocytes and tumor cells

Belloni

Tressler

1990

Cancer Metast Rev

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Endothelium constitutes a highly specialized organ that lines the vascular system and lymphatic channels. This organ is a complex network of arteries, veins, and microvessels that differ in size, structure, and function. The unique and strategic location imposes functional demands on the endothelium that are far greater than just being a passive barrier. Endothelial cells have the ability to differentiate both in structure and function in response to the needs of diverse tissue environments, making this organ extremely heterogeneous. Although vascular endothelial cells share certain common properties, they differ in regard to structure, antigenic and cell surface determinants, adhesion molecules, and metabolic function. The unique cell surface profiles expressed by endothelial cells in different tissue locations can be recognized by specific populations of circulating leukocytes or tumor cells, which contribute to their arrest and invasion patterns. This article attempts to review our current understanding of endothelial cell heterogeneity and its significance to patterns of leukocyte and tumor cell trafficking.

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Section: Morphology and Structural Diversity Of Blood Microvesselsmentioning

confidence: 99%

Microvascular endothelial cell heterogeneity: Interactions with leukocytes and tumor cells

Belloni

Tressler

1990

Cancer Metast Rev

View full text Add to dashboard Cite

show abstract

Quantitative Studies of the Rate of Passage of Protein and Other Nitrogenous Substances Through the Walls of Growing and of Mature Mammalian Blood Capillaries

Cited by 1 publication

References 0 publications

Microvascular endothelial cell heterogeneity: Interactions with leukocytes and tumor cells

Microvascular endothelial cell heterogeneity: Interactions with leukocytes and tumor cells

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