Quantitative studies of haematological values in long-term ovariectomized, ovariohysterectomized and hysterectomized rats

Kuhn, G.; Hardegg, W.

doi:10.1258/002367791780808248

Cited by 5 publications

(5 citation statements)

References 14 publications

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“…Consistent with previous reports, lymphocyte counts were decreased in estrogen-treated animals [27], an effect that achieved statistical significance in SCW-injected animals treated with either E 2 dose (Figure 6B and C). This effect was lymphocyte-specific as total white counts, which are primarily elevated in SCW-injected animals due to increased neutrophils (Table 1), were unchanged by E 2 -treatment (data not shown).…”

Section: Resultssupporting

confidence: 92%

Anti-inflammatory effects of the essential oils of ginger (Zingiber officinale Roscoe) in experimental rheumatoid arthritis

et al. 2016

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Ginger and its extracts have been used traditionally as anti-inflammatory remedies, with a particular focus on the medicinal properties of its phenolic secondary metabolites, the gingerols. Consistent with these uses, potent anti-arthritic effects of gingerol-containing extracts were previously demonstrated by our laboratory using an experimental model of rheumatoid arthritis, streptococcal cell wall (SCW)-induced arthritis. In this study, anti-inflammatory effects of ginger's other secondary metabolites, the essential oils (GEO), which contain terpenes with reported phytoestrogenic activity, were assessed in female Lewis rats with SCW-induced arthritis. GEO (28 mg/kg/d ip) prevented chronic joint inflammation, but altered neither the initial acute phase of joint swelling nor granuloma formation at sites of SCW deposition in liver. Pharmacologic doses of 17-β estradiol (200 or 600 μg/kg/d sc) elicited the same pattern of anti-inflammatory activity, suggesting that GEO could be acting as a phytoestrogen. However, contrary to this hypothesis, GEO had no in vivo effect on classic estrogen target organs, such as uterus or bone. En toto, these results suggest that ginger's anti-inflammatory properties are not limited to the frequently studied phenolics, but may be attributable to the combined effects of both secondary metabolites, the pungent-tasting gingerols and as well as its aromatic essential oils.

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Section: Resultssupporting

confidence: 92%

Anti-inflammatory effects of the essential oils of ginger (Zingiber officinale Roscoe) in experimental rheumatoid arthritis

et al. 2016

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“…Furthermore, other changes such as bodyweight and wet weight of the uterus and vagina also had a relative return to normalcy. In the blood element analysis (Table S1) and serological analysis (Table S2), most of the levels were in the normal range or consistent with the previous literature 53,54 . In addition, the materials can regularly excrete excess polymers and DEHP out of the body through the vagina's redox mechanism and cleaning mechanism.…”

Section: Discussionsupporting

confidence: 83%

“…In the blood element analysis (Table S1) and serological analysis (-Table S2), most of the levels were in the normal range or consistent with the previous literature. 53,54 In addition, the materials can regularly excrete excess polymers and DEHP out of the body through the vagina's redox mechanism and cleaning mechanism. The results indicated that CT-D showed no systemic toxicity and could be a potential treatment for menopausal individuals.…”

Section: Discussionmentioning

confidence: 99%

Development of di(2‐ethylhexyl) phthalate‐containing thioglycolic acid immobilized chitosan mucoadhesive gel as an alternative hormone therapy for menopausal syndrome

Yang

Lin

Liang

et al. 2021

Bioengineering & Transla Med

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Menopausal syndrome includes the symptoms that most women experience owing to hormone changes after menopause. Although hormone replacement therapy is a common treatment for menopausal syndrome, there are still many side effects and challenges hindering research. In this study, thioglycolic acid (TGA)‐immobilized chitosan mucoadhesive gel was synthesized by a new method of low concentration of 1,4‐butanediol diglycidyl ether (BDDE) would encapsulate di(2‐ethylhexyl) phthalate (DEHP) as an alternative hormone replacement therapy for menopausal syndrome. The efficacies of the DEHP‐containing TGA‐chitosan gel (CT‐D) were confirmed and evaluated by materials characterization and in vitro study. Results showed that CT‐D was not cytotoxic and had better mucoadhesive ability than chitosan. The animal model was constructed 1 month after bilateral ovariectomy in SD rats. CT‐D was administered intravaginally every 3 days. Bodyweight, wet weight of the uterus and vagina, vaginal smears, histology, blood element analysis, and serological analysis was used to assess the ability of the material to relieve menopausal syndrome. The results indicated that the combination of the sustained release of DEHP and mucoadhesive TGA‐immobilized chitosan allows the developed CT‐D to relieve the menopausal syndrome through low concentrations of DEHP, which falls in the safety level of the tolerable daily intake of DEHP.

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“…This report, however, does not contain data referring to swine. Kühn [14] has compiled a review about absorption, biotransformation, tissue toxicity and distribution of OTA in porcine excreta. The OTA levels in serum resulting from our experiments which involved parenteral administration corresponded to levels known from feeding experiments [34].…”

Section: Discussionmentioning

confidence: 99%

“…Cereals sampled in Germany exhibited OTA levels between 0.1 and 2379 μg kg −1 [12]. In mixed feeds, levels between 0.1 and 1400 μg kg −1 were found, with average values between 4 and 12 μg kg −1 [12–14]. Mallmann [15] has stated a level of 0.2–3.5 μg kg −1 for pellets.…”

Section: Introductionmentioning

confidence: 99%

Studies of the influence of ochratoxin A on immune and defence reactions in weaners

Müller

Kielstein

Rosner

et al. 1999

Mycoses

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Even in subtoxic amounts, the mycotoxin, ochratoxin A, produced immunomodulation in weaner pigs in a dose-dependent mode. In addition to increased counts of total leukocytes and neutrophils in the blood, reduced lymphocyte levels were observed. There was a striking increase in the counts of eosinophils and of apoptotic phagocytes. Functionally, there was a predominance of the production of reactive oxygen radicals in whole blood, reduced phagocytosis performance and reduced expression of a swine-specific surface marker (SWC1) on lymphocytes. In a few single experiments, clinical manifestations could be demonstrated. Lung clearance and the degree of severity of experimental pneumonia as well as cutaneous hypersensitization may be influenced by ochratoxin A.

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Quantitative studies of haematological values in long-term ovariectomized, ovariohysterectomized and hysterectomized rats

Cited by 5 publications

References 14 publications

Anti-inflammatory effects of the essential oils of ginger (Zingiber officinale Roscoe) in experimental rheumatoid arthritis

Anti-inflammatory effects of the essential oils of ginger (Zingiber officinale Roscoe) in experimental rheumatoid arthritis

Development of di(2‐ethylhexyl) phthalate‐containing thioglycolic acid immobilized chitosan mucoadhesive gel as an alternative hormone therapy for menopausal syndrome

Studies of the influence of ochratoxin A on immune and defence reactions in weaners

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