Quantitative Structure-cytotoxicity Relationship of 3-Benzylidenechromanones

Antiviral and Antitumor Activity of Licorice Root Extracts

“…The logSI value was calculated from -logCC 50 value and -logEC50value, as described previously (20). In order to determine the correlation coefficient, we used the data of method II and the following descriptors calculated by Dragon software ver 6.0.16 (Talete srl, Pisani, Milano, Italy): MATS5p (Moran autocorrelation of lag 5 weighted by polarizability; category, 2D autocorrelations) (21); GATS5p (Geary autocorrelation of lag 5 weighted by polarizability; category, 2D autocorrelations) (22); GATS5i (Geary autocorrelation of lag 5 weighted by ionization potential; category, 2D autocorrelations) (21); NRS (number of ring systems; category, Ring descriptors) (23); J_Dz(Z) (Balaban-like index from Barysz matrix weighted by atomic number; category, 2D matrix-based descriptors) (24); and J_Dz(m) (Balaban-like index from Barysz matrix weighted by mass; 2D matrix-based descriptors) (25).…”

Quantitative Structure–Cytotoxicity Relationship of Chalcones

“…We have confirmed that the TS value thus determined reflects the antitumor potential of test samples, although normal and tumor cells are derived from different tissues (mesenchymal or epithelial tissues, respectively) (21). We did not use human normal oral keratinocytes as controls, since doxorubin and 5-fluorouracil showed potent cytotoxicity against these epithelial cells by an as yet unidentified mechanism (19,22,23). Table II).…”

Quantitative Structure–Cytotoxicity Relationship of 3-(N-Cyclicamino)chromone Derivatives

“…After 48 h, the medium was replaced with 0.1 ml of fresh medium containing different concentrations of single test compounds. Cells were incubated further for 48 h and the relative viable cell number was then determined by the MTT method (2)(3)(4)(5). The relative viable cell number was determined by the absorbance of the cell lysate at 560 nm, using a microplate reader (Infinite F50R; TECAN, Männedorf, Switzerland).…”