Quantitative structure-activity relationships studies with micellar electrokinetic chromatography influence of surfactant type and mixed micelles on estimation of hydrophobicity and bioavailability

Yang, Shenyuan; Bumgarner, Jefferson G.; Kruk, Lisa F. Resotko; Khaledi, Morteza G.

doi:10.1016/0021-9673(95)00773-3

Cited by 117 publications

(60 citation statements)

References 21 publications

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“…13 Higher I values were obtained for HBA compounds ( > 0). Recently, Yang et al 33 pointed out that these differences are due to differences in the HBD strengths of SDS micelles and n-octanol. They recognized three different subgroups, based on the HBA abilities of the compounds: subgroup A with weak HBA strength ( e 0.2), subgroup B with intermediate HBA strength (0.2 < < 0.35) and subgroup C with strong HBA strength ( g 0.35).…”

Section: Resultsmentioning

confidence: 99%

Characterization of Pseudostationary Phases in Micellar Electrokinetic Chromatography by Applying Linear Solvation Energy Relationships and Retention Indexes

1997

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The influence of different solute−micelle interactions on micellar solubilization is studied by using linear solvation energy relationship (LSER) modeling. The LSER results for six anionic micellar systems demonstrate that the migration behavior of neutral species in micellar electrokinetic chromatography (MEKC) is mainly determined by their molar volume and their hydrogen bond acceptor ability. Their polarity and hydrogen bond donor ability are shown to be of minor importance with these anionic surfactants. Large differences in selectivity were observed for sodium dodecyl sulfate (SDS) and mixed SDS/Brij 35 micellar systems, primarily due to different hydrogen bonding characteristics. It is demonstrated that retention indexes can be applied for quantitative characterization of pseudostationary phases in MEKC in a way similar to the use of the Rohrschneider−McReynolds scale in GC. This method facilitates classification of pseudostationary phases according to several solvatochromic quantities with a limited number of experiments. Using this approach, six anionic and two cationic micellar systems were classified according to their hydrogen bond donor and hydrogen bond acceptor strengths, respectively, giving results comparable to those obtained with the LSER models. The relationship between retention indexes and n-octanol−water partition coefficients is treated theoretically and is applied for the prediction of retention indexes in a mixed SDS/Brij 35 micellar system.

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Section: Resultsmentioning

confidence: 99%

Characterization of Pseudostationary Phases in Micellar Electrokinetic Chromatography by Applying Linear Solvation Energy Relationships and Retention Indexes

1997

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“…Recently, several authors paid attention to log Pow screening using MEKC [ 16,19,[28][29][30][31][32]. This microscale separation technique offers some unique advantages such as speed, small sample size, suitability for mixtures and feasibility for automation.…”

Section: Correlation With N-octanol-water Partition Coefficientsmentioning

confidence: 99%

Retention indices in micellar electrokinetic chromatography

Muijselaar¹

1997

Journal of Chromatography A

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“…Khaledi et al [31] have briefly investigated the use of micellar electro-kinetic chromatographic (MEKC) systems for the generation of descriptors for biological properties. They showed that there were reasonable correlations of binding to serum albumin protein and intestinal absorption in the rat against log k'(MEKC) for nine and eight steroids, respectively.…”

Section: Rp-hplc and Mekc Datamentioning

confidence: 99%

“…They showed that there were reasonable correlations of binding to serum albumin protein and intestinal absorption in the rat against log k'(MEKC) for nine and eight steroids, respectively. Khaledi et al [31] pointed out that an advantage of MEKC is that the characteristics of the system can easily be varied by change in the amount and type of surfactant used. Poole and Poole [32] and Roses et al [33] have characterised a number of (MEKC) systems, and have shown how they can be quite finely 'tuned' through the variation in the surfactant composition.…”

Section: Rp-hplc and Mekc Datamentioning

confidence: 99%

Connection between chromatographic data and biological data

Abraham

Gola

Kumarsingh

et al. 2000

Journal of Chromatography B: Biomedical Sciences and Applicatio

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There are no previous references to the direct use of GLC data in the correlation of biological processes, but we show that GLC retention data can be used in the correlation of several such processes involving gaseous solutes. There are a number of reports of RP-HPLC and MEKC data being used in the correlation of biological processes, but they are mostly restricted as to the number and type of solute studied.We show that if chromatographic data are used to obtain solvation descriptors for solutes, and if these descriptors are then used in the correlation of biological processes, that this indirect connection is a much more powerful and generally applicable method than is the direct connection between chromatographic data and biological data.

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Quantitative structure-activity relationships studies with micellar electrokinetic chromatography influence of surfactant type and mixed micelles on estimation of hydrophobicity and bioavailability

Cited by 117 publications

References 21 publications

Characterization of Pseudostationary Phases in Micellar Electrokinetic Chromatography by Applying Linear Solvation Energy Relationships and Retention Indexes

Characterization of Pseudostationary Phases in Micellar Electrokinetic Chromatography by Applying Linear Solvation Energy Relationships and Retention Indexes

Retention indices in micellar electrokinetic chromatography

Connection between chromatographic data and biological data

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