Quantitative structure–activity relationships studies for prediction of antimicrobial activity of synthesized disulfonamide derivatives

Abstract

A new series of disulfonamides were synthesized and assayed as antimicrobial agents against Staphylococcus aureus, Bacillus cereus, and Escherichia coli. The quantitative structure-activity relationship analysis (QSAR) was applied to find out the correlation between experimentally evaluated antimicrobial activities with various parameters of the compounds using stepwise multiple liner regression method. The QSAR analysis revealed that the third-order average connectivity index 3 v A ð Þ was found to have negative correlation. The best QSAR models were further validated by leave-one-out method of cross-validation.

Highly Potent Non-Carboxylic Acid Autotaxin Inhibitors Reduce Melanoma Metastasis and Chemotherapeutic Resistance of Breast Cancer Stem Cells

“…We also replaced the amide linker with a sulfonamide (Scheme ). − Intermediate 18 was obtained in good yield and was converted into two different kinds of sulfonamides. Compounds 19 and 20 have the sulfonamide nitrogen linked to the ring B, whereas in compounds 22 and 23 the sulfonamide nitrogen is linked to ring A.…”

Crystal structure and Hirshfeld surface analysis of N,N′-[ethane-1,2-diylbis(oxy)]bis(4-methylbenzenesulfonamide)

“…Recently, sulfonamides have also been used in the organic synthesis reactions for the synthesis of linear or cyclic oligomers and the introduction of nucleophilic heteroatom functionality to the synthesized molecule (Ni et al, 2015). N,N 0 -ditosylalkane diamine is a disulfonamide synthesized by the tosylation of diamine, and this synthetic molecule has antibacterial properties (Alyar et al, 2011) and has also been used in many organic synthesis reactions (Rong et al, 1998). In this study, the synthesis, crystal structure and Hirshfeld surface analysis are reported for the new potential sulfa drug, N,N 0 -[ethane-1,2-diylbis(oxy)]bis(4methylbenzenesulfonamide).…”

N,N′-(Ethane-1,2-diyl)bis(methanesulfonamide)

“…For analogous disulfonamide compounds, see: Al-Dajani et al (2011a,b). For other analyses and properties of disulfonamide compounds, see: Alyar et al (2011Alyar et al ( , 2012. For their biological and pharmaceutical activity, see: Sahu et al (2007); Innocenti et al (2008).…”