Quantitative structure–activity relationships for phosphoramidothioate toxicity in housefly

Structure-activity study of phosphoramido acid esters as acetylcholinesterasf inhibitors

“…Hansch and co-workers have proposed a general equation [6] describing important roles of hydrophobic (logP), electronic (s), and steric (Es) interactions in AChE inhibition by OPs. Their equation, however, does not elucidate mechanism of action of phosphoramides or consider possible role of other molecular properties such as topology [7], steric effects of substitutions (sterimol properties), and polarization in enzyme inhibition.…”

Synthesis, lipophilicity study and in vitro evaluation of some rodenticides as acetylcholinesterase reversible inhibitors

“…Phosphoramidates rodenticides that usually act by inhibiting AChE and ChE activity, resulting in an accumulation of acetylcholine in neural and non-neural tissues. Accumulation of ACh in neuromuscular junction and synaptic cleft is belived to be the major cause of death in the target species [3]. AChE active center, according to classical theory, consists of an anionic site that binds with the inhibitor and an catalytic site that participates in the enzymes phosphorylation.…”

Synthesis, characterization, and prediction of biological activity of phosphoramide compounds

“…Phosphoramide compound applications have captured the attention of scientists in many fields including medicine (treatment of cancer, AIDS, and Alzheimer's disease), agriculture, (insecticides, herbicides and fungicides), and industry (stabilizers and oxidants), among others [1]. Phosphoramides ( Fig.…”

“…The study of the physicochemical properties and structure-activity relationships (SAR, QSAR and QSPR) of phosphoramides may provide the knowledge to improve their properties. The techniques for studying SAR have been utilized to increase the inhibition potency, and to reduce side effects and environmental damage [1,2]. Literature surveys indicate that the inactivation of AChE by organophosphorus compounds (OPs) is dependent upon the electronic, steric and hydrophobic properties of the OPs as well as the OP three-dimensional structure, which provides the *Corresponding author.…”

“…Literature surveys indicate that the inactivation of AChE by organophosphorus compounds (OPs) is dependent upon the electronic, steric and hydrophobic properties of the OPs as well as the OP three-dimensional structure, which provides the *Corresponding author. E-mail: ghadimi_saied@yahoo.com position of the leaving group site in the active center of the enzyme, thus facilitating phosphorylation [1]. Before the 1930s, there was a lack of knowledge and information about the chemical extent and the rates of chemical processes, as well as the physicochemical properties (i.e.…”