2022
DOI: 10.35516/jjps.v15i3.407
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Quantitative Structure Activity Relationship (QSAR) Investigations and Molecular Docking Analysis of Plasmodium Protein Farnesyltransferase Inhibitors as Potent Antimalarial Agents

Abstract: The development of farnesyltransferase inhibitors based on the benzophenone scaffold directed against Plasmodium falciparum is considered a strategy in malaria treatment. In this work, quantitative structure–activity relationship (QSAR) was performed to predict the protein farnesyltransferase (PFT) inhibitory activities for a series of 36 benzophenone derivatives. The data set was divided into two subsets of training and test sets, and the best model using multiple linear regression (MLR), with the values of i… Show more

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Cited by 1 publication
(3 citation statements)
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References 41 publications
(55 reference statements)
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“…Retinopathy secondary to HCQs is associated with macular retinal pigmentary changes [6]. It was proposed that HCQ toxicity early alters the ganglionic cells with possible secondary macular RNFL thinning and damage [2,3]. The exact way of HCQ toxicity is not fully understood.…”
Section: Discussionmentioning
confidence: 99%
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“…Retinopathy secondary to HCQs is associated with macular retinal pigmentary changes [6]. It was proposed that HCQ toxicity early alters the ganglionic cells with possible secondary macular RNFL thinning and damage [2,3]. The exact way of HCQ toxicity is not fully understood.…”
Section: Discussionmentioning
confidence: 99%
“…Hydroxychloroquine (HCQ) is a well known treatment option for many rheumatological and autoimmune disorders like systemic lupus erythematosus and rheumatoid arthritis [1] and other diseases like malaria [2]. However, many side effects were reported.…”
Section: Introductionmentioning
confidence: 99%
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