Quantitative structure-activity relations for grown inhibition of Chlorella vulgaris suspensions by arylated ureas

Kramer, Claus-Rüdiger; Borns, Eike; Beck, Lothar; Pfeffer, Adolf

doi:10.1016/s0015-3796(80)80020-5

Cited by 9 publications

(7 citation statements)

References 7 publications

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“…Kramer and Trümper [21] reported the in vitro toxicological analysis of a series of mono-substituted phenols to C. vulgaris. This was performed using six hour exposure of toxicant to C. vulgaris under static conditions.…”

Section: Six Hour Chlorella Vulgaris Toxicity Data From the Literaturmentioning

confidence: 99%

“…This was performed using six hour exposure of toxicant to C. vulgaris under static conditions. The inverse of the 50% Chlorella growth inhibitory concentration (in milimoles per litre) (IGC 50 ) was determined spectrophotometrically by absorbance at 680 nm and 750 nm [21].…”

Section: Six Hour Chlorella Vulgaris Toxicity Data From the Literaturmentioning

confidence: 99%

“…Evaluation was achieved by testing two series of chemicals representing the non-polar narcosis [18] and polar narcosis [19,20] mechanisms of action respectively. The results from the tests were used to develop QSARs for both mechanisms, and inter-species relationships with comparative toxicity data in another assay using C. vulgaris [21] and Tetrahymena pyriformis [22 ± 24].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of a Novel Short‐Term Algal Toxicity Assay by the Development of QSARs and Inter‐Species Relationships for Narcotic Chemicals

et al. 2003

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A novel short term toxicity assay utilising the unicellular green alga Chlorella vulgaris is described. The test is based upon the premise that all living organisms contain nonspecific esterase enzymes, the activity of which can be assessed by the measurement of the disappearance of the ester, or appearance of the product. The novel assay described utilises fluorescein diacetate which is metabolised to fluorescein. The appearance of fluorescein, after 15 minutes exposure to the toxicant, was measured fluorimetrically. The concentration causing a 50% decrease in fluorescence, as compared to a control, was determined for 10 non-polar and 10 polar narcotics. Toxicity was related significantly to hydrophobicity for both mechanisms of action, with the QSAR for polar narcosis having a lower slope and higher intercept than that for non-polar narcosis. Significant inter-species relationships of the toxicity data with those for a 6 hour Chlorella vulgaris, and 40 hour Tetrahymena pyriformis, toxicity assay were also observed.

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Section: Six Hour Chlorella Vulgaris Toxicity Data From the Literaturmentioning

confidence: 99%

Section: Six Hour Chlorella Vulgaris Toxicity Data From the Literaturmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluation of a Novel Short‐Term Algal Toxicity Assay by the Development of QSARs and Inter‐Species Relationships for Narcotic Chemicals

et al. 2003

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“…Das im Sinne geringerer Aktivität abweichende Verhalten ortho-substituierter Verbindungen (15 -20) entspricht ebenfalls den Ergebnissen früherer Untersuchungen [12,13,15,16,18,21] und ist auf sterische und konformative Besonderheiten dieser Substitution zurückzuführen. Der über das gesonderte Verhalten bei der Verteilung [23] hinausgehende biologische ortho-Effekt kann in einer für alle Verbindungen gültigen QSAR berücksichtigt werden, indem ortho-substituierten Tetrazolen der Wert 1, allen übrigen Verbindungen der Wert 0 einer Indikatorvariablen X o zugeordnet wird.…”

Section: Ergebnisse Und Diskussionunclassified

“…So wurden im Arbeitskreis bisher isochemische Serien alkyl-und arylsubstituierter Hydrazin-und Harnstoffderivate [11][12][13][14][15][16][17][18][19], disubstituierter Benzole (vgl. Übersicht in [20]) und N-Heterocyclen [21,22] erfolgreich auf ihre wachstumshemmende Wirkung an autotroph kultivierten Chlorella-vulgaris-Suspensionen getestet, wobei für Verbindungen mit "unspezifischen" Substituenten (Alkyl-, Alkoxygruppen, Halogene) gesicherte lineare Beziehungen zwischen algistatischer Aktivität und Hydrophobizität nachgewiesen werden konnten.…”

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Beziehungen zwischen algistatischer Aktivität und physikalisch-chemischen Eigenschaften von 5-Amino-1-aryl-1H-tetrazolen

Schelenz¹

2000

J. prakt. Chem.

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205 5-Amino-1-aryl-1H-tetrazole verfügen mit muskelrelaxierenden und antiinflammatorischen [1,2], antiarthritischen, analgetischen und ulcustherapeutischen [3,4] sowie coccidiostatischen [5, 6] Eigenschaften über ein breites biologisches Wirkungsspektrum. Für isomere 5-Arylamino-1H-tetrazole und die unsubstituierte Leitstruktur 5-Amino-1H-tetrazol wurden darüber hinaus Abstract. A series of 20 5-amino-1-aryl-1H-tetrazoles was synthesized by diazotation of corresponding 1-amino-3-arylguanidines and tested for growth-inhibiting activity against autotrophic Chlorella vulgaris cultures. In the used tests the different algae growth was quantified by photometric measurements at 680 nm. From obtained dosage-effectivity relationships the reciprocal values of isoeffective concentrations c 50 were derived and defined as activity parameters A in QSAR (quantitative structure-activity relationship) studies. It could be shown that the algistatitic activity (log A) of the tested heterocycles strongly depends on hydrophobicity described by their octan-1-ol/water partition coefficients (log P). The calculated linear relationships between log A and log P can be significantly improved by separate treatment of meta-/paraand ortho-substituted compounds or using an indicator variable to describe the lower activity of ortho-substituted 5-amino-1-aryl-1H-tetrazoles in common regression equations. The results are discussed and compared with analogous QSAR found for earlier tested series of N-heterocycles and compounds with urea structure. Abb. 1 Über Extinktionsmessungen (E) erhaltene Wachstumskurven (a) wirkstoffbehandelter Chlorella-vulgaris-Kulturen(¿ c = 4,05×10 -3 mol l -1 , Ú c = 3,22×10 -3 mol l -1 , q c = 2,57×10 -3 mol l -1 , Î c = 2,06×10 -3 mol l -1 , p c = 1,61×10 -3 mol l -1 , + c = 1,03×10 -3 mol l -1 , c = 6,43×10 -4 mol l -1 , Kontrollkultur) und daraus resultierende Dosis-Wirkungs-Kurven (b) zur Ermittlung der Aktivitätsparameter log A 1 und log A 2 für die algistatische Wirksamkeit von 5-Amino-1-phenyl-1H-tetrazol (vgl. Text)

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Quantitative Struktur-Aktivitäts-Beziehungen für die Wachstumshemmung von Chlorella vulgaris-Suspensionen durch N-Arylthioharnstoffe

Kramer

Schelenz

Borns

1982

Biochemie und Physiologie der Pflanzen

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Quantitative structure-activity relations for grown inhibition of Chlorella vulgaris suspensions by arylated ureas

Cited by 9 publications

References 7 publications

Evaluation of a Novel Short‐Term Algal Toxicity Assay by the Development of QSARs and Inter‐Species Relationships for Narcotic Chemicals

Evaluation of a Novel Short‐Term Algal Toxicity Assay by the Development of QSARs and Inter‐Species Relationships for Narcotic Chemicals

Beziehungen zwischen algistatischer Aktivität und physikalisch-chemischen Eigenschaften von 5-Amino-1-aryl-1H-tetrazolen

Quantitative Struktur-Aktivitäts-Beziehungen für die Wachstumshemmung von Chlorella vulgaris-Suspensionen durch N-Arylthioharnstoffe

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