Quantitative structural neuroimaging of mild traumatic brain injury in the Chronic Effects of Neurotrauma Consortium (CENC): Comparison of volumetric data within and across scanners

Wilde, Elisabeth A.; Bigler, Erin D.; Huff, Trevor; Wang, Haonan; Black, Garrett; Christensen, Zachary; Goodrich-Hunsaker, Naomi J.; Petrie, Jo Ann; Abildskov, Tracy J.; Taylor, Brian; Stone, James L.; Tustison, Nicholas J.; Newsome, Mary R.; Levin, Harvey S.; Chu, Zili; York, Gerald E.; Tate, David F.

doi:10.1080/02699052.2016.1219063

Cited by 18 publications

(11 citation statements)

References 18 publications

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“…The 60 scans in the Ochs et al study utilized 29 different scanners. Because variations in MR protocol and scanner hardware are known to be one of the dominant factors preventing direct comparability of MRI volumetry, the present study has a significant advantage over the Ochs et al's study and could be regarded as a novel comparison of FreeSurfer‐ and NeuroQuant®‐derived volumetry.…”

Section: Discussionmentioning

confidence: 94%

Comparing Two Processing Pipelines to Measure Subcortical and Cortical Volumes in Patients with and without Mild Traumatic Brain Injury

Reid

Hannemann

York

et al. 2017

Journal of Neuroimaging

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Section: Discussionmentioning

confidence: 94%

Comparing Two Processing Pipelines to Measure Subcortical and Cortical Volumes in Patients with and without Mild Traumatic Brain Injury

Reid

Hannemann

York

et al. 2017

Journal of Neuroimaging

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“…However, Figure 4 shows a side-by-side boxplot of eTIV and age-adjusted lateral Site differences are also an issue within any multisite study (Nencka et al, 2017), and clearly, there are differences noted across the four MRI acquisition sites, each housing different MRI system platforms from three MRI vendors. As reflected in Figures 1 and 2 and Wilde et al (2016). have shown how site differences result in different volumetric output even in the same individual scanned across different platforms with ostensibly the same MR sequences.…”

Section: Figurementioning

confidence: 86%

“…Also, despite similar to identical image acquisition protocols, differences likely relate to local influences of different MR platforms on image contrasts that subtlety impact how segmentation and classification occur. In a previous CENC investigation, Wilde et al (). have shown how site differences result in different volumetric output even in the same individual scanned across different platforms with ostensibly the same MR sequences.…”

Section: Discussionmentioning

confidence: 96%

Structural neuroimaging in mild traumatic brain injury: A chronic effects of neurotrauma consortium study

Bigler

Abildskov

Eggleston

et al. 2019

Int J Methods Psych Res

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Objectives The chronic effects of neurotrauma consortium (CENC) observational study is a multisite investigation designed to examine the long‐term longitudinal effects of mild traumatic brain injury (mTBI). All participants in this initial CENC cohort had a history of deployment in Operation Enduring Freedom (Afghanistan), Operation Iraqi Freedom (Iraq), and/or their follow‐on conflicts (Operation Freedom's Sentinel). All participants undergo extensive medical, neuropsychological, and neuroimaging assessments and either meet criteria for any lifetime mTBI or not. These assessments are integrated into six CENC core studies—Biorepository, Biostatistics, Data and Study Management, Neuroimaging, and Neuropathology. Methods The current study outlines the quantitative neuroimaging methods managed by the Neuroimaging Core using FreeSurfer automated software for image quantification. Results At this writing, 319 participants from the CENC observational study have completed all baseline assessments including the imaging protocol and tertiary data quality assurance procedures. Conclusions/Discussion The preliminary findings of this initial cohort are reported to describe how the Neuroimaging Core manages neuroimaging quantification for CENC studies.

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“…Additionally, it is relatively insensitive to changes in acquisition parameters (Fischl et al 2004b), making this procedure robust and generalizable across different research settings. While studies show differences in Freesurfer analyses across scanner platforms (Wilde et al 2016), this is likely not problematic in the present study given we only used one scanner.…”

Section: Volumetric Mri Analysismentioning

confidence: 86%

Repeated mild traumatic brain injuries is not associated with volumetric differences in former high school football players

Terry

Miller

2017

Brain Imaging and Behavior

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We investigated potential brain volumetric differences in a sample of former high school football players many years after these injuries. Forty community-dwelling males ages 40-65 who played high school football, but not college or professional sports, were recruited. The experimental group (n = 20) endorsed experiencing two or more mTBIs on an empirically validated mTBI assessment tool (median = 3, range = 2-15). The control group (n = 20) denied ever experiencing an mTBI. Participants completed a self-report index of current mTBI symptomatology and underwent high-resolution T1-weighted MRI scanning, which were analyzed using the Freesurfer software package. A priori regions of interest (ROIs) included total intracranial volume (ICV), total gray matter, total white matter, bilateral anterior cingulate cortex, bilateral hippocampi, and lateral ventricles. ROIs were corrected for head size using a normalization method that took ICV into account. Despite an adequate sample size and being matched on age, education, estimated premorbid IQ, current concussive symptomatology, there were no statistically significant volumetric group differences across all of the ROIs. These data suggest that multiple mTBIs from high school football may not be associated with measurable brain atrophy later in life. Accounting for the severity of injury and chronicity of sport exposure may be especially important when measuring long-term neuroanatomical differences.

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Quantitative structural neuroimaging of mild traumatic brain injury in the Chronic Effects of Neurotrauma Consortium (CENC): Comparison of volumetric data within and across scanners

Abstract: Vigilance when combining data from different sites is suggested and that future efforts address these issues.

Cited by 18 publications

References 18 publications

Comparing Two Processing Pipelines to Measure Subcortical and Cortical Volumes in Patients with and without Mild Traumatic Brain Injury

Comparing Two Processing Pipelines to Measure Subcortical and Cortical Volumes in Patients with and without Mild Traumatic Brain Injury

Structural neuroimaging in mild traumatic brain injury: A chronic effects of neurotrauma consortium study

Repeated mild traumatic brain injuries is not associated with volumetric differences in former high school football players

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