Quantitative STIR of muscle for monitoring nerve regeneration

Viddeleer, Alain R.; Sijens, Paul E.; Ooijen, Peter M. A. van; Kuypers, Paul D.L.; Hovius, Steven E.R.; Deyn, Peter Paul De; Oudkerk, Matthijs

doi:10.1002/jmri.25181

Cited by 10 publications

(7 citation statements)

References 75 publications

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“…One logistic limitation we faced in our study was the time interval between EMG and MRI exams, which could confound results, as muscle denervation can improve or deteriorate depending on the nerve injury type. 10,26 This problem was partially mitigated by excluding patients with EMG and MRI exams performed more than 1 month apart.…”

Section: Discussionmentioning

confidence: 99%

“…However, SI changes remain subjective, as MR SI is inherently dependent on hardware and software settings that are not quantitative in nature. To improve the quantitative aspect, one previous study attempted to calibrate SI levels across different scans on the same MRI magnet to evaluate denervated muscles in the hand 10 . However, this method is semiquantitative and neither repeatable nor reproducible across different scanners or other anatomical regions.…”

Section: Introductionmentioning

confidence: 99%

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Quantitative T₂‐mapping magnetic resonance imaging for assessment of muscle motor unit recruitment patterns

et al. 2021

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Introduction In this study, we aimed to determine whether muscle transverse relaxation time (T2) magnetic resonance (MR) mapping results correlate with motor unit loss, as defined by motor unit recruitment patterns on electromyography (EMG). Methods EMG and 3‐Tesla MRI exams were acquired no more than 31 days apart in subjects referred for peripheral nerve MRI. Two musculoskeletal radiologists qualitatively graded T2‐weighted, fat‐suppressed sequences for severity of muscle edema‐like patterns and manually placed regions of interest within muscles to obtain T2 values from T2‐mapping sequences. Concordance was calculated between qualitative and quantitative MR grades and EMG recruitment categories (none, discrete, decreased) as well as interobserver agreement for both MR grades. Results Thirty‐four muscles (21 abnormal, 13 control) were assessed in 13 subjects (5 females and 8 males; mean age, 46 years) with 14 EMG‐MRI pairs. T2‐relaxation times were significantly (P < .001) increased in all EMG recruitment categories compared with control muscles. T2 differences were not significant between EMG grades of motor unit recruitment (P = .151‐.702). T2 and EMG score concordance was acceptable (Harrellʼs concordance index [c index]: rater A, 0.71; 95% confidence interval [CI], 0.51‐0.87; rater B, 0.77; 95% CI, 0.57‐0.91). Qualitative MRI and EMG score concordance was poor to acceptable (c index: rater A, 0.60; 95% CI, 0.50‐0.79; rater B, 0.72; 95% CI, 0.55‐0.89). T2 values had moderate‐to‐substantial ability to distinguish between absent vs incomplete (ie, decreased or discrete) motor unit recruitment (c index: rater A, 0.78; 95% CI, 0.50‐1.00; rater B, 0.86; 95% CI, 0.57‐1.00). Discussion Quantitative T2 MR muscle mapping is a promising tool for noninvasive evaluation of the degree of motor unit recruitment loss.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quantitative T₂‐mapping magnetic resonance imaging for assessment of muscle motor unit recruitment patterns

et al. 2021

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“…Changes in muscle wet weight and MRI signal could theoretically be used to monitor and predict functional recovery following peripheral nerve repair. However, measurement of muscle wet weight in humans is not possible, although recent pilot studies have explored muscle volumetric changes associated with facial muscle reinnervation [116,117].…”

Section: Mri Of Denervated Musclementioning

confidence: 99%

Strategies for Peripheral Nerve Repair

Wilcox

Gregory

Powell

et al. 2020

Curr. Tissue Microenviron. Rep.

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Purpose of Review This review focuses on biomechanical and cellular considerations required for development of biomaterials and engineered tissues suitable for implantation following PNI, as well as translational requirements relating to outcome measurements for testing success in patients. Recent Findings Therapies that incorporate multiple aspects of the regenerative environment are likely to be key to improving therapies for nerve regeneration. This represents a complex challenge when considering the diversity of biological, chemical and mechanical factors involved. In addition, clinical outcome measures following peripheral nerve repair which are sensitive and responsive to changes in the tissue microenvironment following neural injury and regeneration are required. Summary Effective new therapies for the treatment of PNI are likely to include engineered tissues and biomaterials able to evoke a tissue microenvironment that incorporates both biochemical and mechanical features supportive to regeneration. Translational development of these technologies towards clinical use in humans drives a concomitant need for improved clinical measures to quantify nerve regeneration.

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“…29 A serial decrease in muscle edema and nerve hyperintensity is correlated with nerve regeneration and subsequent functional improvement. 49,52 Tip 8: Become Familiar with the Key Pearls and Pitfalls of Imaging Diagnosis Knowledge of and attention to the most common diagnostic pearls and pitfalls will expedite the MRN learning process, as well as help generate accurate reports and aid patient management.…”

Section: Tip 7: How To Interpret Mrn Studiesmentioning

confidence: 99%

Top-10 Tips for Getting Started with Magnetic Resonance Neurography

Chalian

Chhabra

2019

Semin Musculoskelet Radiol

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Magnetic resonance neurography (MRN), also known as MR neurography, is a dedicated imaging technique for the peripheral nerves, used both in a clinical setting and research. However, like any other new diagnostic processes, there are technical, cost, and patient selection issues to overcome as well as potential imaging pitfalls to recognize before MRN can be adopted efficiently into routine clinical practice. This review focuses on the 10 most important practical tips to get started with MRN with a view to shortening the time needed for radiologists to implement this clinically useful technique into their imaging practices.

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Quantitative STIR of muscle for monitoring nerve regeneration

Cited by 10 publications

References 75 publications

Quantitative T₂‐mapping magnetic resonance imaging for assessment of muscle motor unit recruitment patterns

Quantitative T₂‐mapping magnetic resonance imaging for assessment of muscle motor unit recruitment patterns

Strategies for Peripheral Nerve Repair

Top-10 Tips for Getting Started with Magnetic Resonance Neurography

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Quantitative STIR of muscle for monitoring nerve regeneration

Cited by 10 publications

References 75 publications

Quantitative T2‐mapping magnetic resonance imaging for assessment of muscle motor unit recruitment patterns

Quantitative T2‐mapping magnetic resonance imaging for assessment of muscle motor unit recruitment patterns

Strategies for Peripheral Nerve Repair

Top-10 Tips for Getting Started with Magnetic Resonance Neurography

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Resources

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Quantitative T₂‐mapping magnetic resonance imaging for assessment of muscle motor unit recruitment patterns

Quantitative T₂‐mapping magnetic resonance imaging for assessment of muscle motor unit recruitment patterns