Quantitative SPECT in radiation dosimetry

Zanzonico, Pat; Bigler, Rodney E.; Sgouros, George; Strauss, Ann

doi:10.1016/s0001-2998(89)80035-2

Cited by 26 publications

(17 citation statements)

References 28 publications

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“…The product of D and n is usually called the sensitivity of the detection system. Among the factors that impact the sensitivity are: [1][2][3][4][5][6] 1) the absorption and scattering of photons, 2) collimator efficiency, 3) detector detection efficiency and window fraction, 4) counting rate losses, 5) volume-of-interest (VOI) definition and the partial volume effect, 6) counts detected within the VOI which originated from outside of it, 7) kinetics of the radiopharmaceutical during the period of imaging, 8) reconstruction parameters and implementation in the case of SPECT, and 9) noise. In this review we will focus on compensating for the absorption and scattering of photons.…”

Section: Introductionmentioning

confidence: 99%

An Overview of Attenuation and Scatter Correction of Planar and SPECT Data for Dosimetry Studies

King

Farncombe²

2003

Cancer Biotherapy and Radiopharmaceuticals

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A number of factors impact the accuracy of activity quantitation in planar and single photon emission computed tomographic (SPECT) imaging. Two important such factors are attenuation and scattering in the medium containing the activity. The first removes photons which otherwise would have been included in the images, and the second adds events to the images from photons which would not have otherwise been imaged. A number of methods have been developed to compensate for these biases to activity quantitation. This review will briefly introduce planar quantitation which is commonly used for dosimeter purposes, and then present a slightly more detailed overview of SPECT quantitation which is arguably more accurate. It will conclude by cautioning users of commercial reconstruction software to validate it for quantitation before using it for dosimetric purposes.

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Section: Introductionmentioning

confidence: 99%

An Overview of Attenuation and Scatter Correction of Planar and SPECT Data for Dosimetry Studies

King

Farncombe²

2003

Cancer Biotherapy and Radiopharmaceuticals

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“…different types of filter selected for image processing), the performance of the gamma camera (e.g. sensitivity, uniformity and variable spatial resolution with distance from the detector) and statistical uncertainty (low signal to noise ratio) (Zanzonico et al, 1989). Attenuation is due to (i) absorption of photons leading to loss of counts in the image and (ii) scattering of photons resulting in a lack of the correspondence between the radionuclide distribution in the body and that in the image (Williams, 1985).…”

Section: Quantificationmentioning

confidence: 99%

Use of Single Photon Emission Computed Tomography in Aerosol Studies

Chan¹

1993

Journal of Aerosol Medicine

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Single photon emission computed tomography (SPECT) has distinct advantages over the conventional planar imaging technique in generating more information about radionuclide distribution within the body. The general application of SPECT in lung studies has been extensive, but its specific use in aerosol research is still uncommon. This review focuses on the applications, the advantages and limitations, and the potential of quantification of SPECT in aerosol studies.

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“…Such methods have been published for brain perfusion imaging (Goulding et al 1990;Hooper et al 1990;Lamoureux et al 1990;Maurer et al 1990), myocardial perfusion imaging (Tamaki et al 1982;Garcia et al 1985;Kaul et al 1987;Eisner et al 1988;Reijs et al 1988;Nuyts et al 1989;Stone et al 1989;Ferretti et al 1990;Klein et al 1990;Links et al 1990), myocardial wall motion studies (Yamashita et al 1988;Fischman et al 1989;Graf et al 1990), uptake measurements (DeNardo et al 1989;Iosilevsky et al 1989;Israel et al 1990), leg muscle perfusion (Oshima et al 1989;Yip et al 1990), lung perfusion (Osborne et al 1985), dosimetry (Zanzonico et al 1989) and several other applications.…”

Section: Introductionmentioning

confidence: 99%

Quantitative analysis in single photon emission tomography (SPET)

1992

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Quantitative analysis can improve the sensitivity and specificity of single photon emission tomography (SPET) procedures, as well as reduce inter- and intraobserver variabilities. Quantification of the radioactivity distribution is the ultimate goal of SPET. In this review we consider the basic requirements for an optimum three-dimensional reconstruction of the radionuclide distribution to enable quantification. Attenuation and scatter correction as well as varying resolution are the major problems. In the older SPET systems quantification was hampered by the lack of system sensitivity and sufficient computer power. Therefore, the imaging system was often assumed to be shift invariant and linear and the attenuation throughout the object uniform. More sophisticated solutions have been proposed and with more or less success implemented, but not for application in daily practice. Knowledge (measurement) of the attenuation is often required. New generation SPET systems employing multi-detectors and super minicomputers will ease the implementation of these solutions.

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Quantitative SPECT in radiation dosimetry

Cited by 26 publications

References 28 publications

An Overview of Attenuation and Scatter Correction of Planar and SPECT Data for Dosimetry Studies

An Overview of Attenuation and Scatter Correction of Planar and SPECT Data for Dosimetry Studies

Use of Single Photon Emission Computed Tomography in Aerosol Studies

Quantitative analysis in single photon emission tomography (SPET)

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