Quantitative speciation analysis for the<i>in vivo</i>study of iron metabolism and bioavailability from formula milk fortified with stable isotope enriched iron oxo-hydroxide nanoparticles

Peixoto, Rafaella Regina Alves; Menéndez, Sonia; Fernández-Colomer, Belén; Cadore, Solange; Sanz‐Medel, Alfredo; Sánchez, Marı́a Luisa Fernández

doi:10.1039/c8ja00364e

Cited by 8 publications

(2 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IPD determines isotope ratios in a sample following the administration of enriched element species and deconvolutes the overall isotopic pattern to calculate the contribution from endogenous and the different external (experimental) sources. The technique was initially developed in 1997 by Hintelmann et al [ 239 ] to study the artefactual formation of Hg species from inorganic Hg and was subsequently applied to understand the uptake and biotransformation during supplementation and fortification [ 240 , 241 ], the impact of different chemical species [ 242 ], mineral metabolism [ 243 ], mechanisms in oxidative stress [ 244 ], in vivo implant degradation [ 245 ] and the impact of specific element species.…”

Section: Isotope Ratio Analysismentioning

confidence: 99%

Facets of ICP-MS and their potential in the medical sciences—Part 1: fundamentals, stand-alone and hyphenated techniques

Clases

Vega

2022

Anal Bioanal Chem

View full text Add to dashboard Cite

Since its inception in the early 80s, inductively coupled plasma–mass spectrometry has developed to the method of choice for the analysis of elements in complex biological systems. High sensitivity paired with isotopic selectivity and a vast dynamic range endorsed ICP-MS for the inquiry of metals in the context of biomedical questions. In a stand-alone configuration, it has optimal qualities for the biomonitoring of major, trace and toxicologically relevant elements and may further be employed for the characterisation of disrupted metabolic pathways in the context of diverse pathologies. The on-line coupling to laser ablation (LA) and chromatography expanded the scope and application range of ICP-MS and set benchmarks for accurate and quantitative speciation analysis and element bioimaging. Furthermore, isotopic analysis provided new avenues to reveal an altered metabolism, for the application of tracers and for calibration approaches. In the last two decades, the scope of ICP-MS was further expanded and inspired by the introduction of new instrumentation and methodologies including novel and improved hardware as well as immunochemical methods. These additions caused a paradigm shift for the biomedical application of ICP-MS and its impact in the medical sciences and enabled the analysis of individual cells, their microenvironment, nanomaterials considered for medical applications, analysis of biomolecules and the design of novel bioassays. These new facets are gradually recognised in the medical communities and several clinical trials are underway. Altogether, ICP-MS emerged as an extremely versatile technique with a vast potential to provide novel insights and complementary perspectives and to push the limits in the medical disciplines. This review will introduce the different facets of ICP-MS and will be divided into two parts. The first part will cover instrumental basics, technological advances, and fundamental considerations as well as traditional and current applications of ICP-MS and its hyphenated techniques in the context of biomonitoring, bioimaging and elemental speciation. The second part will build on this fundament and describe more recent directions with an emphasis on nanomedicine, immunochemistry, mass cytometry and novel bioassays. Graphical abstract

show abstract

Section: Isotope Ratio Analysismentioning

confidence: 99%

Facets of ICP-MS and their potential in the medical sciences—Part 1: fundamentals, stand-alone and hyphenated techniques

Clases

Vega

2022

Anal Bioanal Chem

View full text Add to dashboard Cite

show abstract

“…In a separate report, Fe-based nanoparticle metabolisms and bioavailability in rats was evaluated. 121 Rats were fed a milk formula fortied with isotopically enriched Feoxihydroxide NPs, 57 Fe III -NPs, and FeSO 4 . Aer two weeks of feeding, rats were sacriced and liver and blood samples obtained.…”

Section: Ironmentioning

confidence: 99%

Atomic spectrometry update: review of advances in elemental speciation

Clough

Harrington

Hill

et al. 2020

J. Anal. At. Spectrom.

View full text Add to dashboard Cite

show abstract

Iron nanoparticles as food additives and food supplements, regulatory and legislative perspectives

Chavarría-Fernández,

Jiménez-Alvarado,

Santos-López

et al. 2024

Food Sci Biotechnol

View full text Add to dashboard Cite

Quantitative speciation analysis for thein vivostudy of iron metabolism and bioavailability from formula milk fortified with stable isotope enriched iron oxo-hydroxide nanoparticles

Abstract: For the first time, the study of iron metabolism and bioavailability, administered as stable iron isotope enriched nanoparticles, was carried out by speciation analysis.

Cited by 8 publications

References 30 publications

Facets of ICP-MS and their potential in the medical sciences—Part 1: fundamentals, stand-alone and hyphenated techniques

Facets of ICP-MS and their potential in the medical sciences—Part 1: fundamentals, stand-alone and hyphenated techniques

Atomic spectrometry update: review of advances in elemental speciation

Iron nanoparticles as food additives and food supplements, regulatory and legislative perspectives

Contact Info

Product

Resources

About