Quantitative Solubility Relationships and the Effect of Water Uptake in Triglyceride/Monoglyceride Microemulsions

Abstract

This study provides a potential universal framework for predicting relative drug solubility in mixtures containing fully saturated triglycerides and monoglycerides.

Lipase B from Candida antarctica binds to hydrophobic substrate–water interfaces via hydrophobic anchors surrounding the active site entrance

“…Finally, the density and water content of the tributyrin phase of both systems converged. The final water content of the tributyrin-water interface was calculated to be 1.8% (w/w), which is similar to the experimentally determined value for the more hydrophobic tricaprylin of 0.2% (w/w) [31]. The resulting interface model was used for all further MD simulations.…”

Molecular interactions of polymer oleogelation

“…The length and the number of unsaturations of the side chains determine not only the overall hydrophobicity of the triglyceride but also its molecular weight and volume. 41 The groups of Lizaso 12 and Heng 13,42,43 have studied the gelation of EC in phthalate mono-and diesters and propylene glycol dicaprylates. They have both proposed that the molar volume of the solvent influences the gel rheological properties.…”

Interfacial and stability study of microbubbles coated with a monostearin/monopalmitin-rich food emulsifier and PEG40 stearate

“…Very long-term stability of microbubble populations is rare because film desorption and wrinkling effects due to fluid bulk viscoelasticity will generally take place [22,26]. However, we believe this effect is minimized in the case of microbubbles coated with MYVATEX/PEG40S and similar mixtures that we have observed in the past [16,20] because the condensed monolayer coating is nearly "solid," i.e., gel-like, and with extremely low monomer solubility in the water phase [27]. Based upon these arguments, we would expect that the most stable microbubble population of the emulsifiers tried here will be formed in the solution containing long chains capable of obtaining low surface tension, high elastic modulus, and solid-like behavior, i.e., MYVATEX/PEG40S.…”