Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[&lt;em&gt;n&lt;/em&gt;]uril

Chio, Weng‐I Katherine; Davison, Gemma; Jones, Tabitha; Liu, Jia; Parkin, Ivan P.; Lee, Tung‐Chun

doi:10.3791/61682-v

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Colloidal NPs synthesised via wet chemistry are a staple of SERS [59][60][61][62]. Gold NPs can be cheaply and reproducibly synthesised using techniques such as the Turkevich-Frens method [59][60][61].…”

Section: Colloidal Nps Deposited On Rigid Substratesmentioning

confidence: 99%

Fabrication of nanostructured electrodes for electrochemical surface-enhanced Raman spectroscopy (E-SERS): A review

Jones

2023

Materials Science and Technology

View full text Add to dashboard Cite

Electrochemical surface-enhanced Raman spectroscopy (E-SERS) is a powerful technique for the detection of trace levels of analytes in solution. It has wide ranging applications with a particular focus on biomarker detection. To perform E-SERS, nanostructured plasmonic metal electrodes are needed. Currently, a variety of fabrication methods are employed. This review defines the requirements for E-SERS electrodes and then describes and evaluates the current fabrication methods. The limitations of these techniques are discussed with the balance between ease of manufacture and magnitude of enhancement being identified as the key issue. Finally, suggestions for future areas of research are presented.

show abstract

Section: Colloidal Nps Deposited On Rigid Substratesmentioning

confidence: 99%

Fabrication of nanostructured electrodes for electrochemical surface-enhanced Raman spectroscopy (E-SERS): A review

Jones

2023

Materials Science and Technology

View full text Add to dashboard Cite

show abstract

“…However, these techniques are restricted under lab environment only, due to sophisticated sampling, time consuming, prone to contamination and low detection limit. Thus, these methods are difficult to employ for onsite detection [5].…”

Section: Introductionmentioning

confidence: 99%

Microfluidic biochip platform sensitized by AgNPs for SERS based rapid detection of uric acid

Mishra¹,

Goel²,

Dwivedi³

2022

J. Micromech. Microeng.

View full text Add to dashboard Cite

Herein, a novel Microfluidic-biochip enabled with Surface Enhanced Raman Spectroscopy (SERS) as a readout has been demonstrated for Uric acid (UA) detection as point-of care device. Three different biochip designs (D1, D2 and D3) containing pillars in a microchannel with different bending ratios were conceived and optimized for various mixing parameters using a multiphysics simulation tool. The microchannel, integrated with pillars, provide pressure perturbation, sharp corners, and variation in bending ratio improves phase shift and mixing index. Subsequently the microfluidic-biochips were fabricated by a combination of photo-and soft-lithography, and bonding strength between two PolyDiMethylSiloxane (PDMS) substrates were found stable up to a flow rate of 1.8ml/min. Further to realize SERS activity in the microfluidic-biochip, cubic shape silver nanoparticles (AgNPs), with an average size ~68 nm, were synthesized using poly-ol method. The SERS activity was optimized by simultaneously flowing AgNPs and crystal violet (CV) dye of 10-6 M, with double inlet in the reservoir and highest sensitivity was achieved in the D3 biochip. Further, D3 biochip was employed for detection of extended concentrations of CV and UA. The Enhancement factor (EF) limit of detection (LoD) and Relative standard deviation (RSD) was found to be 2x107, 8.9x10-11 and 2.7% respectively for CV and 3.1x103, 3.2x10-7 and 2.9% respectively for UA. Interference of UA with lactic acid (LA) has been tested and device was able to detect signature peaks of both biomarkers up to 50x10-9M concentration. Thus, the developed Microfluidic-biochip device has potential to be used in a point of care (POC) setting for onsite detection of biomarkers.

show abstract

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[<em>n</em>]uril

Cited by 2 publications

References 0 publications

Fabrication of nanostructured electrodes for electrochemical surface-enhanced Raman spectroscopy (E-SERS): A review

Fabrication of nanostructured electrodes for electrochemical surface-enhanced Raman spectroscopy (E-SERS): A review

Microfluidic biochip platform sensitized by AgNPs for SERS based rapid detection of uric acid

Contact Info

Product

Resources

About