Quantitative RT-PCR for Expression of a Small Subset of Genes Identifies Novel Prognostic Subgroups in High-Risk Pediatric Precursor B-Cell Acute Lymphoblastic Leukemia (HR-ALL): Clinical Applicability of Gene Expression Microarray Data from Children’s Oncology Group Trials.
Abstract:Accurate risk stratification constitutes the fundamental paradigm of treatment in acute lymphoblastic leukemia (ALL), allowing the intensity of therapy to be tailored to the patient’s risk of relapse. We have recently identified 2 known (E2A-PBX1, MLL) and 6 novel cluster groups with varying prognostic significance within a high risk ALL cohort (COG P9906) using gene expression profiling. Key genes predicted membership in these novel cluster groups, including MUC4, GPR110, IGJ (poorest outcome cluster) and CEN… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.