Biochemical Pharmacology volume 80, issue 9, P1317-1325 2010 DOI: 10.1016/j.bcp.2010.07.022 View full text
Kimiko Ishiguro, Yong-Lian Zhu, Krishnamurthy Shyam, Philip G. Penketh, Raymond P. Baumann, Alan C. Sartorelli

Abstract: AbstractO 6 -Alkylguanine-DNA alkyltransferase (AGT) mediates tumor resistance to alkylating agents that generate guanine O 6 -chloroethyl (Onrigin ™ and carmustine) and O 6 -methyl (temozolomide) lesions; however, the relative efficiency of AGT protection against these lesions and the degree of resistance to these agents that a given number of AGT molecules produces are unclear. Measured from differential cytotoxicity in AGT-ablated and AGT-intact HL-60 cells containing 17,000 AGT molecules/cell, AGT produce…

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