Quantitative relationship between body weight gain in adulthood and incident type 2 diabetes: a meta‐analysis

Kodama, Satoru; Horikawa, Chika; Fujihara, Kazuya; Yoshizawa, Shunsuke; Yachi, Yoko; Tanaka, Shiro; Ohara, Nobumasa; Matsunaga, Satoshi; Yamada, Takaho; Hanyu, Osamu; Sone, Hirohito

doi:10.1111/obr.12129

Cited by 114 publications

(76 citation statements)

References 64 publications

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“…Accordingly, weight gain from adolescence throughout adulthood has been linked to higher risks of diabetes, cardiovascular disease, and cancers in the colorectum, breast, and pancreas, as well as premature death 2134 35 36 37 In contrast, lifestyle based weight loss interventions have been shown to result in favorable changes in cardiometabolic risk factors and potentially lower mortality 3839 40…”

Section: Discussionmentioning

confidence: 99%

Trajectory of body shape in early and middle life and all cause and cause specific mortality: results from two prospective US cohort studies

Song

et al. 2016

BMJ

102

101

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Objective To assess body shape trajectories in early and middle life in relation to risk of mortality.Design Prospective cohort study.Setting Nurses’ Health Study and Health Professionals Follow-up Study.Population 80 266 women and 36 622 men who recalled their body shape at ages 5, 10, 20, 30, and 40 years and provided body mass index at age 50, followed from age 60 over a median of 15-16 years for death.Main outcome measures All cause and cause specific mortality.Results Using a group based modeling approach, five distinct trajectories of body shape from age 5 to 50 were identified: lean-stable, lean-moderate increase, lean-marked increase, medium-stable/increase, and heavy-stable/increase. The lean-stable group was used as the reference. Among never smokers, the multivariable adjusted hazard ratio for death from any cause was 1.08 (95% confidence interval 1.02 to 1.14) for women and 0.95 (0.88 to 1.03) for men in the lean-moderate increase group, 1.43 (1.33 to 1.54) for women and 1.11 (1.02 to 1.20) for men in the lean-marked increase group, 1.04 (0.97 to 1.12) for women and 1.01 (0.94 to 1.09) for men in the medium-stable/increase group, and 1.64 (1.49 to 1.81) for women and 1.19 (1.08 to 1.32) for men in the heavy-stable/increase group. For cause specific mortality, participants in the heavy-stable/increase group had the highest risk, with a hazard ratio among never smokers of 2.30 (1.88 to 2.81) in women and 1.45 (1.23 to 1.72) in men for cardiovascular disease, 1.37 (1.14 to 1.65) in women and 1.07 (0.89 to 1.30) in men for cancer, and 1.59 (1.38 to 1.82) in women and 1.10 (0.95 to 1.29) in men for other causes. The trajectory-mortality association was generally weaker among ever smokers than among never smokers (for all cause mortality: P for interaction <0.001 in women and 0.06 in men). When participants were classified jointly according to trajectories and history of type 2 diabetes, the increased risk of death associated with heavier body shape trajectories was more pronounced among participants with type 2 diabetes than those without diabetes, and those in the heavy-stable/increase trajectory and with a history of diabetes had the highest risk of death.Conclusions Using the trajectory approach, we found that heavy body shape from age 5 up to 50, especially the increase in middle life, was associated with higher mortality. In contrast, people who maintained a stably lean body shape had the lowest mortality. These results indicate the importance of weight management across the lifespan.

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Section: Discussionmentioning

confidence: 99%

Trajectory of body shape in early and middle life and all cause and cause specific mortality: results from two prospective US cohort studies

Song

et al. 2016

BMJ

102

101

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“…Association between glycated haemoglobin (HbA1c) and other parameters. Measured in 172 individuals overweight/obesity, high waist circumference and metabolic syndrome; as found in other scientific publications [21][22][23][24].…”

Section: Discussionmentioning

confidence: 99%

Improving cardiovascular health in Spanish seafarers

Romero-Paredes¹,

Reinoso-Barbero²,

González-Gómez³

et al. 2016

International Maritime Health

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“…However, WHR is a reflection of abdominal obesity which is known to trigger changes to the body metabolism that cause adipose tissues to release increased amounts of fatty acids, glycerol, hormones, pro-inflammatory cytokines and other factors that are involved in development of insulin resistance hence poor control of blood glucose level. Tremendous increases in rate of T2D in recent years have been attributed primarily to the rise in obesity worldwide (Lean, 2000;Zimmet et al, 2001;and Kodama et al, 2014). This rise is also not unconnected with the conveniences of modern life resulting in popularity of high fat, high energy diets and convenient foods.…”

Section: Discusionmentioning

confidence: 99%