The efficacy of the novel aquaculture feed ingredient Novacq TM to improve resilience against viral infection and mortality in Black Tiger shrimp, Penaeus monodon, was examined. Juvenile 4-6 g shrimp were fed either a control diet or treatment diet which included 10% Novacq TM for a 26 d conditioning period. Control and treatment shrimp were subsequently each divided into a no injection, saline injection or GAV challenge injection sub-treatment with each having four replicate tanks of ten shrimp. After injection, shrimp survival in all six treatments was monitored daily over a 14 d experimental bioassay period. Two of the four replicate tanks for each treatment were pleopod sampled for later GAV load quantification at day 0 and 14 of the experimental period (i.e. 'less handling'; survival comparison), whilst the other two replicate tanks were pleopod sampled for later GAV load quantification at days 0, 3, 7, 10 and 14 (i.e. 'more handling'; GAV load comparison). In the survival comparison, shrimp fed Novacq TM had significantly higher survival rates (P >0.05) when GAV challenged compared to shrimp not fed Novacq TM . Similarly, shrimp fed Novacq TM had marginally higher survival rates when injected with saline and compared to their respective control. Shrimp that received no injection showed the same survival rates irrespective of diet. In the GAV load comparison GAV loads were generally lower in shrimp fed Novacq TM when compared to their respective GAV challenge or saline injection controls. Survival and GAV load data indicate that Novacq TM improves resilience against viral infection and mortality in Black Tiger shrimp, Penaeus monodon.