Quantitative Rapid Test for Detection and Monitoring of Active Pulmonary Tuberculosis in Nonhuman Primates

Zhou, Zijie; Hooij, Anouk van; Vervenne, Richard A. W.; Sombroek, Claudia C.; Fat, Elisa M. Tjon Kon; Ottenhoff, Tom H. M.; Corstjens, Paul L. A. M.; Verreck, Frank A. W.; Geluk, Annemieke

doi:10.3390/biology10121260

Cited by 2 publications

(2 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, a Quantitative Rapid serologic test for detection and monitoring of active pulmonary TB in nonhuman primates has shown great promise in the tested macaques [ 72 ]; we should expect that in the near future, additional diagnostic tools will be available to rapidly and accurately diagnose and confirm TB in non-human primates.…”

Section: Discussionmentioning

confidence: 99%

Mycobacterium tuberculosis sensu stricto in African Apes, What Is Its True Health Impact?

Sánchez

Hidalgo-Hermoso

2022

Pathogens

View full text Add to dashboard Cite

Since the Symposium on Mycobacterial Infections of Zoo Animals held at the National Zoological Park, Smithsonian Institution in 1976, our understanding of tuberculosis (TB) in non-domestic animals has greatly expanded. Throughout the past decades, this knowledge has resulted in improved zoo-habitats and facilities design, stricter biosecurity measures, and advanced diagnostic methods, including molecular techniques, that have significantly decreased the number of clinical disease caused by Mycobacterium tuberculosis in apes under human care settings. In the other hand, exponential growth of human populations has led to human encroachment in wildlife habitat which has resulted in increased inter-species contact and recurrent conflict between humans and wild animals. Although it is widely accepted that non-human primates are susceptible to M. tb infection, opinions differ with regard to the susceptibility to develop disease amongst different taxa. Specifically, some authors suggest that African apes are less susceptible to clinical tuberculosis than other species of primates. The aim of this review article is to evaluate the current scientific literature to determine the actual health impact of disease caused by Mycobacterium tuberculosis and more specifically Mycobacterium tuberculosis sensu stricto in African apes. The literature review included literature databases: Web of Science, Pubmed, Scopus, Wiley, Springer and Science direct, without temporal limit and proceedings of annual conferences in the field of wildlife health. Our general inclusion criteria included information about serological, molecular, pathological (macroscopic and/or microscopic), and clinical evidence of TB in African apes; while our, our more stringent inclusion selection criteria required that in addition to a gross pathology, a molecular test confirmed Mycobacterium tuberculosis sensu stricto as the cause of disease or death. We identified eleven reports of tuberculosis in African apes; of those, only four reports met the more stringent selection criteria that confirmed M. tb sensu stricto in six individuals. All reports that confirmed M. tb sensu stricto originated from zoological collections. Our review suggests that there is little evidence of disease or mortality caused by M. tb in the different species of African apes both under human care and free ranging populations. Additional studies are needed in free-ranging, semi-captive populations (sanctuaries) and animals under human care (zoos and rescue centers) to definitely conclude that this mycobacteria has a limited health effect in African ape species.

show abstract

Section: Discussionmentioning

confidence: 99%

Mycobacterium tuberculosis sensu stricto in African Apes, What Is Its True Health Impact?

Sánchez

Hidalgo-Hermoso

2022

Pathogens

View full text Add to dashboard Cite

show abstract

“…LF assays incorporating unique, sensitive UCP particles have been applied in the development of point-of-care (POC) tests for human diseases such as TB ( 20 ), leprosy ( 21 ), schistosomiasis ( 22 , 23 ), and bronchiolitis (caused by Respiratory Syncytial Virus) ( 18 ). Other than for human samples, UCP-LFAs have also been pilot tested in studies conducted on samples from rodents, wild animals, and NHPs ( 11 , 24 – 27 ). The potential of these UCP-LFAs is enormous; for example, storage of assay reagents at room temperature and the use of battery-operated (stand-alone) portable strip readers have allowed the use of these tests at several sites worldwide for the detection of human infectious diseases ( 20 ).…”

Section: Introductionmentioning

confidence: 99%

Development of lateral flow assays to detect host proteins in cattle for improved diagnosis of bovine tuberculosis

Khalid,

Pierneef,

van Hooij

et al. 2023

Front. Vet. Sci.

Self Cite

View full text Add to dashboard Cite

Bovine tuberculosis (bTB), caused by Mycobacterium bovis (M. bovis) infection in cattle, is an economically devastating chronic disease for livestock worldwide. Efficient disease control measures rely on early and accurate diagnosis using the tuberculin skin test (TST) and interferon-gamma release assays (IGRAs), followed by culling of positive animals. Compromised performance of TST and IGRA, due to BCG vaccination or co-infections with non-tuberculous mycobacteria (NTM), urges improved diagnostics. Lateral flow assays (LFAs) utilizing luminescent upconverting reporter particles (UCP) for quantitative measurement of host biomarkers present an accurate but less equipment- and labor-demanding diagnostic test platform. UCP-LFAs have proven applications for human infectious diseases. Here, we report the development of UCP-LFAs for the detection of six bovine proteins (IFN-γ, IL-2, IL-6, CCL4, CXCL9, and CXCL10), which have been described by ELISA as potential biomarkers to discriminate M. bovis infected from naïve and BCG-vaccinated cattle. We show that, in line with the ELISA data, the combined PPDb-induced levels of IFN-γ, IL-2, IL-6, CCL4, and CXCL9 determined by UCP-LFAs can discriminate M. bovis challenged animals from naïve (AUC range: 0.87–1.00) and BCG-vaccinated animals (AUC range: 0.97–1.00) in this cohort. These initial findings can be used to develop a robust and user-friendly multi-biomarker test (MBT) for bTB diagnosis.

show abstract

Quantitative Rapid Test for Detection and Monitoring of Active Pulmonary Tuberculosis in Nonhuman Primates

Cited by 2 publications

References 58 publications

Mycobacterium tuberculosis sensu stricto in African Apes, What Is Its True Health Impact?

Mycobacterium tuberculosis sensu stricto in African Apes, What Is Its True Health Impact?

Development of lateral flow assays to detect host proteins in cattle for improved diagnosis of bovine tuberculosis

Contact Info

Product

Resources

About