Quantitative Radiology

Herskovits, Edward H.

doi:10.1016/b978-0-12-411638-2.00001-x

Cited by 1 publication

(2 citation statements)

References 118 publications

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“…Molecular-genetic imaging approaches allow visualizing and quantifying biochemical processes at the cellular and molecular level (Bhang & Pomper, 2012; Minn et al, 2014; Pomper & Fisher, 2014). The basic components for molecular-genetic imaging are gene promoters, reporters, and gene delivery vehicles.…”

Section: Approaches Currently Used To Detect Metastatic Lesions (Omentioning

confidence: 99%

“…X-ray, radiographs, computed tomography scan (CT scan), nuclear imaging including PET and SPECT, MRI are few examples of currently available approaches in the clinical arena (Minn et al, 2014; Pomper & Fisher, 2014). In this particular section, we will focus on the clinical applications of these approaches, particularly in the context of bone metastasis, which is very difficult to detect using conventional protein-based biomarkers.…”

Section: Approaches Used To Detect Metastatic Lesions (On a Clinicmentioning

confidence: 99%

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Detecting Tumor Metastases

Menezes

Das

Minn

et al. 2016

Advances in Cancer Research

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Metastasis is the complex process by which primary tumor cells migrate and establish secondary tumors in an adjacent or distant location in the body. Early detection of metastatic disease and effective therapeutic options for targeting these detected metastases remain impediments to effectively treating patients with advanced cancers. If metastatic lesions are identified early, patients might maximally benefit from effective early therapeutic interventions. Further, monitoring patients whose primary tumors are effectively treated for potential metastatic disease onset is also highly valuable. Finally, patients with metastatic disease can be monitored for efficacy of specific therapeutic interventions through effective metastatic detection techniques. Thus, being able to detect and visualize metastatic lesions is key and provides potential to greatly improve overall patient outcomes. In order to achieve these objectives, researchers have endeavored to mechanistically define the steps involved in the metastatic process as well as ways to effectively detect metastatic progression. We presently overview various preclinical and clinical in vitro and in vivo assays developed to more efficiently detect tumor metastases, which provides the foundation for developing more effective therapies for this invariably fatal component of the cancerous process.

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Section: Approaches Currently Used To Detect Metastatic Lesions (Omentioning

confidence: 99%

Section: Approaches Used To Detect Metastatic Lesions (On a Clinicmentioning

confidence: 99%