Quantitative Radioisotope Renography: The Derivation of Physiological Data by Deconvolution Analysis Using a Single-Injection Technique

Abstract

S U M M A R Y1. An improved method is presented for quantifying all the information relating to individual kidney function that is contained in the renogram.2. From the convolution theorem, functions are derived which are equivalent to the renograms that would be obtained by simultaneous injections of the indicator into each renal artery, fractionated according to renal blood flow.3. The 'pulse-input' renograms so derived can have the blood background subtracted by a process of 'kinetic discrimination', which dispenses with the prior injection of human serum albumin.4. The 'pulse-input' renograms with blood background subtracted are analysed by the techniques used in conventional indicator dilution methods.5. The value of this approach in clinical and experimental work is illustrated by comparison of examples drawn from 400 consecutive studies of patients with normal data.

The Clinical Measurement of Skeletal Blood Flow

“…The deconvolution algorithm used has proved satisfactory in previous physiologica1 studies (Scholer & Code, 1954; Love et al, 1973; Reeve & Crawley, 1974). Its practical limitations apply equally to the various alternative techniques for data analysis; in particular, the input datamust not contain a large component due to random noise (Hart & Sondheimer, 1970) and the sampling frequency of the input data must be at least double were used simultaneously (Fig.…”

A comparison of deconvolution and the Rutland-Patlak plot in parenchymal renal uptake rate

“…In practice, it is best obtained either as the plateau value of the retention function [Figure 2], or as the slope of R-P plot (i.e., “ K ”) [Figure 1]. [21] The R-P plot starts with an initial value and rises with a slope. The first proof of the R-P plot[38] actually demonstrated that the initial value was equal to the blood background subtraction factor “ F ” (the interception of the straight line with y -axis as shown in Figure 1), and that the slope was similar to the uptake constant “ H (0)” (the plateau value as shown in Figure 2).…”

“…Unfortunately, based on a renogram, one cannot tell whether the maximal transit time is longer or shorter than the acquisition time. [20] Deconvolution analysis has been a useful technique for analyzing organ function in nuclear medicine[4921] for a considerable time. There are three established techniques plus one more recent approach.…”

Abnormalities of Renal Transport of Sodium o-[131I]Iodohippurate (Hippuran) in Essential Hypertension

“…After the same injection, quantitative renography can be used to calculate the fraction of renal plasma flow going to each kidney (Britton & Brown, 1971) and the frequency distribution or spectrum of transit times for Hippuran from renal artery to ureter (Brown & Britton, 1972;Reeve & Crawley, 1974). Hippuran, like p-aminohippurate, is both filtered by the glomerulus and secreted by the proximal tubule, so that its appearance time at the ureter is primarily determined by the speed with which the filtrate passes down the nephrons.…”