1974
DOI: 10.1042/cs0470317
|View full text |Cite
|
Sign up to set email alerts
|

Quantitative Radioisotope Renography: The Derivation of Physiological Data by Deconvolution Analysis Using a Single-Injection Technique

Abstract: S U M M A R Y1. An improved method is presented for quantifying all the information relating to individual kidney function that is contained in the renogram.2. From the convolution theorem, functions are derived which are equivalent to the renograms that would be obtained by simultaneous injections of the indicator into each renal artery, fractionated according to renal blood flow.3. The 'pulse-input' renograms so derived can have the blood background subtracted by a process of 'kinetic discrimination', which … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
11
0
2

Year Published

1976
1976
2012
2012

Publication Types

Select...
9

Relationship

2
7

Authors

Journals

citations
Cited by 18 publications
(13 citation statements)
references
References 12 publications
0
11
0
2
Order By: Relevance
“…The deconvolution algorithm used has proved satisfactory in previous physiologica1 studies (Scholer & Code, 1954; Love et al, 1973; Reeve & Crawley, 1974). Its practical limitations apply equally to the various alternative techniques for data analysis; in particular, the input datamust not contain a large component due to random noise (Hart & Sondheimer, 1970) and the sampling frequency of the input data must be at least double were used simultaneously (Fig.…”
Section: Discussionmentioning
confidence: 94%
“…The deconvolution algorithm used has proved satisfactory in previous physiologica1 studies (Scholer & Code, 1954; Love et al, 1973; Reeve & Crawley, 1974). Its practical limitations apply equally to the various alternative techniques for data analysis; in particular, the input datamust not contain a large component due to random noise (Hart & Sondheimer, 1970) and the sampling frequency of the input data must be at least double were used simultaneously (Fig.…”
Section: Discussionmentioning
confidence: 94%
“…In practice, it is best obtained either as the plateau value of the retention function [Figure 2], or as the slope of R-P plot (i.e., “ K ”) [Figure 1]. [21] The R-P plot starts with an initial value and rises with a slope. The first proof of the R-P plot[38] actually demonstrated that the initial value was equal to the blood background subtraction factor “ F ” (the interception of the straight line with y -axis as shown in Figure 1), and that the slope was similar to the uptake constant “ H (0)” (the plateau value as shown in Figure 2).…”
Section: Theorymentioning
confidence: 99%
“…Unfortunately, based on a renogram, one cannot tell whether the maximal transit time is longer or shorter than the acquisition time. [20] Deconvolution analysis has been a useful technique for analyzing organ function in nuclear medicine[4921] for a considerable time. There are three established techniques plus one more recent approach.…”
Section: Introductionmentioning
confidence: 99%
“…After the same injection, quantitative renography can be used to calculate the fraction of renal plasma flow going to each kidney (Britton & Brown, 1971) and the frequency distribution or spectrum of transit times for Hippuran from renal artery to ureter (Brown & Britton, 1972;Reeve & Crawley, 1974). Hippuran, like p-aminohippurate, is both filtered by the glomerulus and secreted by the proximal tubule, so that its appearance time at the ureter is primarily determined by the speed with which the filtrate passes down the nephrons.…”
Section: Introductionmentioning
confidence: 99%