Quantitative proteomics reveals Shexiang Baoxin Pill exerts cardioprotective effects by preserving energy metabolism in a rat model of myocardial infarction

Feng, Yuanming; Yu, Yue; Tian, Sai; Zhou, Yanheng; Chen, Xiangling; Ye, Ji; Liu, Qian; Zhou, Hu; Zhang, Weidong

doi:10.1016/j.jep.2020.113460

Cited by 11 publications

(8 citation statements)

References 44 publications

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“…Nineteen RCTs [ 23 – 41 ] and five PEs [ 42 – 46 ] were included in this study, involving 1849 patients (observation group: 926, control group: 923) and 209 animals, respectively. The years of publication range from 1999 to 2021.…”

Section: Resultsmentioning

confidence: 99%

“…The number of animals ranges from 6 to 81, and the sample size of patients is from 59 to 200 in each study. In the included PEs, three experiments [ 43 – 45 ] were carried out in metabolomics, one experiment [ 42 ] involved pharmacodynamics, and one experiment [ 46 ] was carried out in quantitative proteomics. In the included RCTs, 5 trials [ 37 – 41 ] used PCI both in the observation group and in the control group.…”

Section: Resultsmentioning

confidence: 99%

“…Five PEs [ 42 – 46 ] were assessed by the SYRCLE risk of bias tool (Supplementary Table 3 ). Due to lack of reporting, random housing and blinding of performance were judged as “some concerns” in all PEs.…”

Section: Resultsmentioning

confidence: 99%

“…Five experiments [ 42 – 46 ] were included that studied SBP for AMI in AMI animal models. The histology analysis in an experiment [ 42 ] showed that the endothelial nitric oxide synthase (eNOS) was mainly distributed in the myocardial interstitium, and SBP increased the expression of eNOS in the left ventricle.…”

Section: Resultsmentioning

confidence: 99%

“…SBP downregulated homocysteine to protect against ROS-induced endothelial cell injury [ 43 , 45 ]. The proteomics analysis showed that peroxiredoxin-3 in SBP protects against oxidative stress in a rat model of myocardial infarction [ 46 ].…”

Section: Resultsmentioning

confidence: 99%

See 4 more Smart Citations

Shexiang Baoxin Pill for Acute Myocardial Infarction: Clinical Evidence and Molecular Mechanism of Antioxidative Stress

Guo

Qin

et al. 2021

Oxidative Medicine and Cellular Longevity

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Acute myocardial infarction (AMI) has been a preclinical and clinical concern due to high hospitalization rate and mortality. This study was aimed at evaluating the effectiveness and safety of Shexiang Baoxin Pill (SBP) for AMI and exploring the possible mechanism of oxidative stress. Six databases were searched on March 26, 2021. Twenty-four studies were included and accessed by the RoB 2.0 or SYRCLE tool. Compared with routine treatment (RT), SBP showed the effectiveness in the clinical efficacy ( RR = 1.15 , 95% CI [1.06, 1.25]), left ventricular ejection fraction (LVEF) ( SMD = 0.73 , 95% CI [0.62, 0.95]), glutathione (GSH) ( SMD = 2.07 , 95% CI [1.51, 2.64]), superoxide dismutase (SOD) ( SMD = 0.92 , 95% CI [0.58, 1.26]), malondialdehyde (MDA) ( SMD = − 4.23 , 95% CI [-5.80, -2.66]), creatine kinase-myocardial band (CK-MB) ( SMD = − 4.98 , 95% CI [-5.64, -4.33]), cardiac troponin I (cTnI) ( SMD = − 2.17 , 95% CI [-2.57, -1.76]), high-sensitivity C-reactive protein (Hs-CRP) ( SMD = − 1.34 , 95% CI [-1.56, -1.12]), interleukin-6 (IL-6) ( SMD = − 0.99 , 95% CI [-1.26, -0.71]), triglycerides (TG) ( SMD = − 0.52 , 95% CI [-0.83, -0.22]), flow-mediated dilation (FMD) ( SMD = 1.39 , 95% CI [1.06, 1.72]), von Willebrand Factor (vWF) ( SMD = − 1.77 , 95% CI [-2.39, -1.15]), nitric oxide (NO) ( SMD = 0.89 , 95% CI [0.65, 1.13]), and recurrent rate ( RR = 0.30 , 95% CI [0.15, 0.59]). But SBP adjunctive to RT plus PCI had no improvements in almost pooled outcomes except for the Hs-CRP ( SMD = − 1.19 , 95% CI [-1.44, -0.94]) and TG ( SMD = − 0.25 , 95% CI [-0.48, -0.02]). Laboratory findings showed that SBP enhanced the endothelial nitric oxide synthase (eNOS) activity and regulated laboratory indexes especially for homocysteine. In conclusion, SBP has adjunctive effects on AMI via the mechanism of antioxidative stress. The current evidence supports the use of SBP for mild and moderate AMI patients.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Shexiang Baoxin Pill for Acute Myocardial Infarction: Clinical Evidence and Molecular Mechanism of Antioxidative Stress

Guo

Qin

et al. 2021

Oxidative Medicine and Cellular Longevity

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Fatty acid metabolism disorders and potential therapeutic traditional Chinese medicines in cardiovascular diseases

Liu

Zhang

et al. 2023

Phytotherapy Research

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Cardiovascular diseases are currently the primary cause of mortality in the whole world. Growing evidence indicated that the disturbances in cardiac fatty acid metabolism are crucial contributors in the development of cardiovascular diseases. The abnormal cardiac fatty acid metabolism usually leads to energy deficit, oxidative stress, excessive apoptosis, and inflammation. Targeting fatty acid metabolism has been regarded as a novel approach to the treatment of cardiovascular diseases. However, there are currently no specific drugs that regulate fatty acid metabolism to treat cardiovascular diseases. Many traditional Chinese medicines have been widely used to treat cardiovascular diseases in clinics. And modern studies have shown that they exert a cardioprotective effect by regulating the expression of key proteins involved in fatty acid metabolism, such as peroxisome proliferator‐activated receptor α and carnitine palmitoyl transferase 1. Hence, we systematically reviewed the relationship between fatty acid metabolism disorders and four types of cardiovascular diseases including heart failure, coronary artery disease, cardiac hypertrophy, and diabetic cardiomyopathy. In addition, 18 extracts and eight monomer components from traditional Chinese medicines showed cardioprotective effects by restoring cardiac fatty acid metabolism. This work aims to provide a reference for the finding of novel cardioprotective agents targeting fatty acid metabolism.

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Dimeric sesquiterpenoids and anti-inflammatory constituents of Sarcandra glabra

Lei

et al. 2022

Bioorganic Chemistry

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Quantitative proteomics reveals Shexiang Baoxin Pill exerts cardioprotective effects by preserving energy metabolism in a rat model of myocardial infarction

Cited by 11 publications

References 44 publications

Shexiang Baoxin Pill for Acute Myocardial Infarction: Clinical Evidence and Molecular Mechanism of Antioxidative Stress

Shexiang Baoxin Pill for Acute Myocardial Infarction: Clinical Evidence and Molecular Mechanism of Antioxidative Stress

Fatty acid metabolism disorders and potential therapeutic traditional Chinese medicines in cardiovascular diseases

Dimeric sesquiterpenoids and anti-inflammatory constituents of Sarcandra glabra

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