Quantitative Proteomic Profiling Reveals Sexual Dimorphism in the Retina and RPE of C57BL6 mice.
Geeng-Fu Jang,
John S. Crabb,
Allison Grenell
et al.
Abstract:Background
Sex as a biological variable is not a common consideration in molecular mechanistic or preclinical studies of retinal diseases. Understanding the sexual dimorphism of adult RPE and retina under physiological conditions is an important first step in improving our understanding of sex-based physio-pathological mechanisms.
Methods
Isobaric tags for relative and absolute quantitation (iTRAQ) were used for quantitative proteomics of male and female mouse retina and RPE (10 mice of each sex for each tis… Show more
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