Quantitative proteomic analysis of human serum using tandem mass tags to predict cardiovascular risks in patients with psoriasis

Kim, Na Young; Back, Ji Hyun; Shin, Jongmin; Ji, Mi‐Jung; Lee, Su Jin; Park, Yae Eun; Park, Hyun‐Mee; Gu, Man Bock; Lee, Ji Eun; Kim, Jeong Eun

doi:10.1038/s41598-023-30103-2

Cited by 3 publications

(1 citation statement)

References 67 publications

(68 reference statements)

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“…These genes included ATP2A2 , CD34 , CD40LG , DDX41 , FADD , FGF2 , FLNA , HBA1 , KANTR , MB , SLC2A1 , TAC1 , and ZBTB8OS . Previous literature has linked CALD1, TEK, TRPV1, ATP2A2 , and SMUG1 to CVDs, supporting the findings from our functional mutation analysis 57 – 61 . Further research must be conducted to solidify these claims regarding the significance of these genes.…”

Section: Resultssupporting

confidence: 91%

Functional mutation, splice, distribution, and divergence analysis of impactful genes associated with heart failure and other cardiovascular diseases

Mhatre,

Abdelhalim,

Degroat

et al. 2023

Sci Rep

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Cardiovascular disease (CVD) is caused by a multitude of complex and largely heritable conditions. Identifying key genes and understanding their susceptibility to CVD in the human genome can assist in early diagnosis and personalized treatment of the relevant patients. Heart failure (HF) is among those CVD phenotypes that has a high rate of mortality. In this study, we investigated genes primarily associated with HF and other CVDs. Achieving the goals of this study, we built a cohort of thirty-five consented patients, and sequenced their serum-based samples. We have generated and processed whole genome sequence (WGS) data, and performed functional mutation, splice, variant distribution, and divergence analysis to understand the relationships between each mutation type and its impact. Our variant and prevalence analysis found FLNA, CST3, LGALS3, and HBA1 linked to many enrichment pathways. Functional mutation analysis uncovered ACE, MME, LGALS3, NR3C2, PIK3C2A, CALD1, TEK, and TRPV1 to be notable and potentially significant genes. We discovered intron, 5ʹ Flank, 3ʹ UTR, and 3ʹ Flank mutations to be the most common among HF and other CVD genes. Missense mutations were less common among HF and other CVD genes but had more of a functional impact. We reported HBA1, FADD, NPPC, ADRB2, ADBR1, MYH6, and PLN to be consequential based on our divergence analysis.

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Section: Resultssupporting

confidence: 91%

Functional mutation, splice, distribution, and divergence analysis of impactful genes associated with heart failure and other cardiovascular diseases

Mhatre,

Abdelhalim,

Degroat

et al. 2023

Sci Rep

View full text Add to dashboard Cite

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Mass Spectrometry-Based Proteomics Analysis Unveils PTPRS Inhibits Proliferation and Inflammatory Response of Keratinocytes in Psoriasis

Zheng,

Zhou,

et al. 2024

Inflammation

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Platelet activation: a promoter for psoriasis and its comorbidity, cardiovascular disease

Jiang,

Chen

et al. 2023

Front. Immunol.

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Psoriasis is a chronic inflammatory skin disease with a prevalence of 0.14% to 1.99%. The underlying pathology is mainly driven by the abnormal immune responses including activation of Th1, Th17, Th22 cells and secretion of cytokines. Patients with psoriasis are more likely to develop cardiovascular disease (CVD) which has been well recognized as a comorbidity of psoriasis. As mediators of hemostasis and thromboinflammation, platelets play an important part in CVD. However, less is known about their pathophysiological contribution to psoriasis and psoriasis-associated CVD. A comprehensive understanding of the role of platelet activation in psoriasis might pave the path for more accurate prediction of cardiovascular (CV) risk and provide new strategies for psoriasis management, which alleviates the increased CV burden associated with psoriasis. Here we review the available evidence about the biomarkers and mechanisms of platelet activation in psoriasis and the role of platelet activation in intriguing the common comorbidity, CVD. We further discussed the implications and efficacy of antiplatelet therapies in the treatment of psoriasis and prevention of psoriasis-associated CVD.

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Quantitative proteomic analysis of human serum using tandem mass tags to predict cardiovascular risks in patients with psoriasis

Cited by 3 publications

References 67 publications

Functional mutation, splice, distribution, and divergence analysis of impactful genes associated with heart failure and other cardiovascular diseases

Functional mutation, splice, distribution, and divergence analysis of impactful genes associated with heart failure and other cardiovascular diseases

Mass Spectrometry-Based Proteomics Analysis Unveils PTPRS Inhibits Proliferation and Inflammatory Response of Keratinocytes in Psoriasis

Platelet activation: a promoter for psoriasis and its comorbidity, cardiovascular disease

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