Quantitative Probing of Cu<sup>2+</sup> Ions Naturally Present in Single Living Cells

Lee, Jun-Ho; Lee, Hwa‐Rim; Pyo, Jaeyeon; Jung, Youngseob; Seo, Jae Hwa; Ryu, Hye Guk; Kim, Kyong‐Tai; Je, Jung Ho

doi:10.1002/adma.201600161

Cited by 20 publications

(13 citation statements)

References 37 publications

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“…Moreover, microfiber tips have been used as fluorescence probes for bio/chemical detection. The nanoscale fiber tip is typically fabricated by cleaving a tapered fiber and functionalized using metal layer coated on the end face or functional materials (e.g., bioreceptors [275], dyes [276,277], semiconductor/doped-polymer nanowires [278], and plasmonic structures [279]) attached to the tip. The micro-tip sensors exhibited excellent capabilities of single-cell-level investigations into chemical reactions in biosystems.…”

Section: Frequency-based Sensorsmentioning

confidence: 99%

Recent Progress in Microfiber-Optic Sensors

Luo

Chen

2021

Photonic Sens

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Recently, microfiber-optic sensors with high sensitivity, fast response times, and a compact size have become an area of interest that integrates fiber optics and nanotechnology. Distinct advantages of optical microfiber, such as large accessible evanescent fields and convenient configurability, provide attractive benefits for micro- and nano-scale optical sensing. Here, we review the basic principles of microfiber-optic sensors based on a broad range of microstructures, nanostructures, and functional materials. We also introduce the recent progress and state-of-the-art in this field and discuss the limitations and opportunities for future development.

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Section: Frequency-based Sensorsmentioning

confidence: 99%

Recent Progress in Microfiber-Optic Sensors

Luo

Chen

2021

Photonic Sens

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“…For instance, CuInS 2 /ZnS core–shell QDs deposited on a solar cell have brought an increased conversion efficiency as a result of more light absorption . CdSe/ZnS QDs are mostly picked up for their high PL QY, stability, and superiority in quantitative probing of Cu 2+ for selective PL quenching by Cu 2+ ions . Li et al illustrated a tunable, transparent, and stretchable luminescent film for anticounterfeiting applications through employing colloidal CdS/ZnS/ZnS:Mn 2+ /ZnS core/multishell QDs embedded in polydimethylsiloxane (PDMS) …”

Section: Applicationsmentioning

confidence: 99%

Design Principles and Material Engineering of ZnS for Optoelectronic Devices and Catalysis

Liu

Chen

et al. 2018

Adv Funct Materials

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ZnS, as one of the first semiconductors discovered and a rising material star, has embraced exciting breakthroughs in the past few years. To shed light on the design principles and engineering techniques of ZnS for improved/novel optoelectronic properties, the fundamental mechanisms and commonly employed strategies are proposed in this review. Recent progress on modifications of ZnS allows it to be extensively and effectively used in versatile applications, including transparent conductors, UV photodetectors, luminescent devices, and catalysis, which are clearly and comprehensively summarized in this work. Novel functional devices springing up from the newly developed ZnS-based materials are highlighted as well. This review not only provides a scientific insight into the advances of ZnS-based materials, but also touches on the future opportunities in this inspiring field.The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adfm.201802029. relatively high charge recombination rate and low charge transport process inhibit the optoelectronic properties of ZnS as a high-performance photodetector. As a window layer of optoelectronic devices, a lack of high electrical conductivity typically hinders the practical use of ZnS in solar cells, photodiodes, light-emitting devices, etc. As a photocatalyst, the transparency of ZnS becomes a drawback as it suffers from a poor utilization of sunlight.There is not a perfect material, but the potential of developing a material is beyond limitation. The past few years have witnessed extensive designing and engineering of ZnS to explore its potentials in specific applications. [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] This review summarizes the recent breakthroughs on ZnS-based materials as excellent candidates in optoelectronic devices, photocatalysis, and other novel functional devices. More importantly, it sheds light on the design principles and fundamental mechanisms of the improved performance of ZnS through strategies such as developing novel nanostructures, bandgap engineering, alloying with other materials, etc. To the best of our knowledge, it is the first comprehensive review on the design principles and material engineering of ZnS for novel/improved properties and intended applications. Briefly, current literature on a variety of ZnS-based structures was first summarized, ranging from 0D to 2D nanostructures. Then, the representative applications of ZnS-based materials are described, which are mainly consisted of four parts, as shown in Figure 1: transparent conductors, UV photodetectors, luminescent devices, and catalysis. Each part contains the latest design strategies of ZnS for the intended applications, fabrication techniques, representative examples, and the state-of-the-art devices. Finally, it outlines the challenges and opportunities in each field. In particular, we provide our perspectives on the future research directions of ZnS in energy and environment.

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“…The fabrication of nanoprobes for subcellular measurement is important to fully characterize cellular function. Single-cell interrogation at the nanoscale is carried out mainly via optical approaches, such as the use of fluorescent dyes, [1][2][3] quantum dots or nanoparticles, [4][5][6][7][8][9][10][11] nanofiber probes, 12,13 single nanowire probes, [14][15][16][17][18][19] and planar photonic crystal nanowaveguides; 20 mechanical approaches, such as the use of atomic force microscopy probes [21][22][23] and nanobeam arrays; 24 and electrochemical approaches, such as the utilization of single metal nanowires, 25,26 pillars, or tube electrodes. [27][28][29][30][31] Dyes and quantum-dot-based probes have attracted much attention in biology, attributable to their photoluminescence (PL), and achieved great success in measuring the temperature of cells and their organelles, 32,33 as they can be easily phagocytosed by cells due to their ultrasmall dimensions and are quite robust against external disturbances.…”

Section: Introductionmentioning

confidence: 99%

“…Optical nanofibers have become increasingly popular owing to their excellent optical waveguiding property, high flexibility, and ease of integration 34 and thus have been applied for the detection of intracellular pH 14 and ionic concentrations. 15 Notably, the existing fiber probes are passive in nature and serve only as conduits to guide light signals into/from a cell but not as a complete optical functional module for physical or chemical label-free sensing. Accordingly, most nanoprobe techniques still have to modify other nanoparticles, resulting in the low functional integration of structures.…”

Section: Introductionmentioning

confidence: 99%

Label-free fiber nanograting sensor for real-time in situ early monitoring of cellular apoptosis

Wang

Zhang

et al. 2022

Adv. Photon.

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The achievement of functional nanomodules for subcellular label-free measurement has long been pursued in order to fully understand cellular functions. Here, a compact label-free nanosensor based on a fiber taper and zinc oxide nanogratings is designed and applied for the early monitoring of apoptosis in individual living cells. Because of its nanoscale dimensions, mechanical flexibility, and minimal cytotoxicity to cells, the sensing module can be loaded in cells for long term in situ tracking with high sensitivity. A gradual increase in the nuclear refractive index during the apoptosis process is observed, revealing the increase in molecular density and the decrease in cell volume. The strategy used in our study not only contributes to the understanding of internal environmental variations during cellular apoptosis but also provides a new platform for nonfluorescent fiber devices for investigation of cellular events and understanding fundamental cell biochemical engineering.

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Quantitative Probing of Cu²⁺ Ions Naturally Present in Single Living Cells

Cited by 20 publications

References 37 publications

Recent Progress in Microfiber-Optic Sensors

Recent Progress in Microfiber-Optic Sensors

Design Principles and Material Engineering of ZnS for Optoelectronic Devices and Catalysis

Label-free fiber nanograting sensor for real-time in situ early monitoring of cellular apoptosis

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Quantitative Probing of Cu2+ Ions Naturally Present in Single Living Cells

Cited by 20 publications

References 37 publications

Recent Progress in Microfiber-Optic Sensors

Recent Progress in Microfiber-Optic Sensors

Design Principles and Material Engineering of ZnS for Optoelectronic Devices and Catalysis

Label-free fiber nanograting sensor for real-time in situ early monitoring of cellular apoptosis

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Resources

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Quantitative Probing of Cu²⁺ Ions Naturally Present in Single Living Cells