Quantitative Prediction of Ionic Liquid-Gas Partition Coefficients for Residual Solvents by HS-GC

Abstract

The aim of this study was to establish a method to determine the partition coefficients of residual solvents (eight aliphatic alcohols) between three ionic liquid and gas phases by headspace gas chromatography (HS-GC). In this article, a modeling study was carried out using statistical analysis, and a general model was established to predict the ionic liquid-gas partition coefficients (K) for these solvents. Factors that affect the logK, including parameters of physical properties of these solvents, such as T b (the temperature of boiling points) and logP O/W (the logarithm of the octanol/water partition coefficient for a solvent), were used in the model. Through this model the logK of the analyzed solvent can be calculated, and the sensitivity of the method is associated with logK. Therefore, this study provides helpful guidance for the application of ionic liquids as matrix media to the analysis of solvents by HS-GC.

Rapid and Sensitive Analysis of Volatile Components of Different Parts of Clausena lansium by Ionic Liquid Based Headspace Gas Chromatography-Mass Spectrometry

“…ILs, as a group of novel solvents, are used as ideal matrix media due to their inherent properties, including negligible vapor pressure, high thermal stability, and excellent solubility. In our group, we have applied ILs as headspace matrix media for analyzing residuals in pharmaceuticals [20,21]. In our current study, more volatile components, including components with high-boiling points and low content, were detected using only 100 mg of sample by [Bmim][BF 4 ] based HS-GC-MS.…”

Volatile sampling by headspace techniques

“…As commented above, the extremely low vapor pressure of ILs promoted their use as matrix media in green HS-GC-MS procedures for analysis of RSs in the pharmaceutical field [21][22][23][24][25][26]. As an example, Laus et al [21] showed the utility of using 1-N-butyl-3-methylimidazolium dimethyl phosphate ([BMIM] [DMP]) as solvent for the successful HS-GC-MS analysis of DMSO, N-methylpyrrolidone, sulfolane, tetralin, and ethylene glycol in a realistic matrix of commonly-used excipients (carboxymethylcellulose, magnesium stearate, guar flour, and corn starch) in pharmaceutical products.…”