Quantitative phase imaging of cellular and subcellular structures for non-invasive screening diagnostics of socially significant diseases

Evaluation of the lymphocyte interphase nuclei phenotype by quantitative phase imaging (QPI) in patients with endometrial ovarian cysts

“…При этом особое значение приобретает показатель фазовой тол-щины (или фазовой высоты) мононуклеарной клетки, который отражает особенность упаковки хроматина в ядре и, соответственно, активности процессов белкового синтеза. Таким образом, данная величина позволяет косвенно оценить ак-тивность ядросодержащей клетки и может счи-таться высокочувствительным и объективным критерием оценки нарушений иммунного гомео-стаза [20,21].…”

Acoustofluidic phase microscopy in a tilted segmentation-free configuration

“…For example, QPM has been effectively used to measure the RI and the osmotic-induced volume changes in erythrocytes [3], providing a precise morphometric description of the cells. The same approach on white blood cells allowed for the identification of robust biomarkers suitable to discriminate between healthy and diseased states [6]. Moreover, for non homogeneous materials, such as living cells, QPM can be seen as a contrast enhancement technique to highlight organelles and structures with different RI.…”

“…The same approach on white blood cells allowed for the identification of robust biomarkers suitable for discriminating between healthy and diseased states. 6 Moreover, for nonhomogeneous materials, such as living cells, QPM can be seen as a contrast enhancement technique to highlight organelles and structures with different RIs. This perspective has been adopted to describe intracellular motility and dynamic evolution.…”