Quantitative parameters of intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI): potential application in predicting pathological grades of pancreatic ductal adenocarcinoma

Ma, Wanling; Zhang, Guangwen; Ren, Jing; Pan, Qiwei; Wen, Didi; Zhong, Jinman; Zhang, Zhuoli; Yi, Huan

doi:10.21037/qims.2018.04.08

Cited by 27 publications

(39 citation statements)

References 44 publications

(93 reference statements)

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“…IVIM is a noninvasive in vivo measurement which offers a quantitative technique to measure maternal placental perfusion and no contrast agent is used. Applications of IVIM were mainly in the liver, pancreas, kidney and prostate analysis currently [3][4][5][6][7][8]. Owing to the highly vascularized characteristic of the placenta with both a high blood fraction and a large perfusion component, it is also appropriate for evaluation with IVIM.…”

Section: Introductionmentioning

confidence: 99%

Can introvoxel incoherent motion MRI be used to differentiate patients with placenta accreta spectrum disorders?

Lü

et al. 2019

Preprint

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Objective Background The incidence of PAS disorders increased rapidly in recent years, and introvoxel incoherent motion (IVIM) MRI has been applied in the assessment of placenta. The study aims to investigate whether the parameters from IVIM can be used to differentiate patients with PAS disorders complicating placenta previa and secondly to differentiate different categories of PAS disorders. Methods The study participants were comprised of 99 patients with placenta previa, including 16 patients with placenta accreta, 51 patients with increta, 8 patients with percreta and 24 patients without PAS disorders between 28+0 and 39+6 weeks. IVIM MRI was performed on a 1.5T scanner. Perfusion fraction (f), pseudodiffusion coefficient (D*) and standard diffusion coefficient (D) were calculated. Results Women with PAS disorders had a higher perfusion fraction (p=0.019) than women without the disease. Multiple comparisons showed perfusion fraction in patients without PAS disorders was significantly lower than in patients with placenta accreta and percreta(P=0.018 and 0.033 respectively), but was not lower than in patients with increta(p=1). Conclusion Patients with placenta accreta and percreta differed in placental perfusion fraction from women with increta and without PAS disorders.

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Section: Introductionmentioning

confidence: 99%

Can introvoxel incoherent motion MRI be used to differentiate patients with placenta accreta spectrum disorders?

Lü

et al. 2019

Preprint

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“… 44 This approach allows separation of the diffusion and perfusion signal component of the water molecules, and could improve tissue characterisation such that tumours might be distinguished by pathological grade. 45 , 46 However, these existing DWI models lack specificity for various elements of the tissue microstructure, such as cell size, shape, intracellular structure, and perfusion effects. An improved framework for describing diffusion behaviour was proposed by Panagiotaki et al 47 This Vascular, Extracellular, and Restricted Diffusion for Cytometry in Tumours (VERDICT) method uses a three-compartment model to specifically account for intracellular, interstitial and intravascular water and map descriptors, which form key components of histopathological tumour assessment (Fig.…”

Section: Advances In Mrimentioning

confidence: 99%

How rapid advances in imaging are defining the future of precision radiation oncology

et al. 2019

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Imaging has an essential role in the planning and delivery of radiotherapy. Recent advances in imaging have led to the development of advanced radiotherapy techniques-including image-guided radiotherapy, intensity-modulated radiotherapy, stereotactic body radiotherapy and proton beam therapy. The optimal use of imaging might enable higher doses of radiation to be delivered to the tumour, while sparing normal surrounding tissues. In this article, we review how the integration of existing and novel forms of computed tomography, magnetic resonance imaging and positron emission tomography have transformed tumour delineation in the radiotherapy planning process, and how these advances have the potential to allow a more individualised approach to the cancer therapy. Recent data suggest that imaging biomarkers that assess underlying tumour heterogeneity can identify areas within a tumour that are at higher risk of radio-resistance, and therefore potentially allow for biologically focussed dose escalation. The rapidly evolving concept of adaptive radiotherapy, including artificial intelligence, requires imaging during treatment to be used to modify radiotherapy on a daily basis. These advances have the potential to improve clinical outcomes and reduce radiation-related long-term toxicities. We outline how recent technological advances in both imaging and radiotherapy delivery can be combined to shape the future of precision radiation oncology.

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“…As an alternate method for diagnosing acute pancreatitis, MR imaging (MRI) and MR cholangiopancreatography (MRCP) shows great potential in clinical applications (7). The benefits of MRI for acute pancreatitis are as follows: (I) the MRI sequence for T2-weighted image (T2WI) is highly sensitive to liquid and thus can visualize a small amount of liquid in mild pancreatitis, T2WI can characterize non-liquid materials in the pancreatic collections better than CT (6); (II) MRI clearly shows the areas of necrosis without enhancement and is safe for patients who are unable to receive iodinated contrast material because of allergies or kidney failure (8,9); (III) MRCP can noninvasively evaluate the changes of the bile ducts (especially the distal bile duct, which is difficult for ultrasound to show) and pancreatic duct system and help diagnose the etiology of the disease (10); (IV) recent studies have found that in addition to the air bubbles, high signals on the MRI diffusion-weighted imaging (DWI) sequences can also indicate the existence of infection to preliminarily determine whether the accumulation is infected (11); (V) novel MRI techniques such as intravoxel incoherent motion (IVIM) imaging can assess both perfusion and diffusion of the diseased tissues (12)(13)(14); (VI) MRI can be used to stage AP and clearly show local complications. It has been reported that non-enhanced MRI is more reliable and accurate than CT in estimating the severity of AP (9); and (VII) finally, MRI does not require ionizing radiation and does not lead to adverse effects on the human body.…”

Section: Introductionmentioning

confidence: 99%

MR imaging for acute pancreatitis: the current status of clinical applications

Sun¹,

Zuo²,

Lin³

et al. 2019

Ann. Transl. Med

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Acute pancreatitis is a common clinical acute abdomen. Imaging examinations play an important role in the management of acute pancreatitis. MR imaging is a noninvasive examination with high tissue contrast and a variety of acquisition sequences that can help determine the diagnosis, complications and severity of acute pancreatitis. The acute pancreatitis classification working group modified the Atlanta classification in 2012 to improve clinical evaluations and standardize the radiologic nomenclature for acute pancreatitis. In particular, the redefinition of necrotizing pancreatitis offers a new understanding of this disease. In clinical practice, there is still a lack of unifying standards between radiologists and physicians, such as for the imaging features of pseudocysts, walled-off necrosis, peripancreatic necrosis and especially for the MR imaging features of acute pancreatitis. In this article, we review the 2012 revised Atlanta classification of acute pancreatitis and recent advances in the clinical applications of MR imaging (MRI) in acute pancreatitis by showing how MRI can provide more optimized information for clinical diagnosis and treatment plan.

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Quantitative parameters of intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI): potential application in predicting pathological grades of pancreatic ductal adenocarcinoma

Cited by 27 publications

References 44 publications

Can introvoxel incoherent motion MRI be used to differentiate patients with placenta accreta spectrum disorders?

Can introvoxel incoherent motion MRI be used to differentiate patients with placenta accreta spectrum disorders?

How rapid advances in imaging are defining the future of precision radiation oncology

MR imaging for acute pancreatitis: the current status of clinical applications

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