Quantitative nailfold capillary microscopy findings in patients with acrocyanosis compared with patients having systemic sclerosis and control subjects

Monticone, Giovanna; Colonna, Laura; Palermi, G.; Bono, R.; Puddu, Pietro

doi:10.1067/mjd.2000.103046

Cited by 31 publications

(20 citation statements)

References 10 publications

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“…It is worth to note that the enlargement of capillary loops is not characteristic for only one disease, because similar changes were found in diabetes types I and II [24], acrocyanosis, [25] or chronic autoimmune thyroiditis [26]. In our study all participants did not suffer from any of these diseases.…”

Section: Discussionsupporting

confidence: 60%

Videocapillaroscopic Alterations in Alopecia Areata

Gerkowicz

Krasowska

Pietrzak

et al. 2013

BioMed Research International

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Alopecia areata (AA) is a common hair disorder observed in dermatological practice; however, the exact mechanisms that lead to the hair loss are still unknown. Disturbances in the blood supply of hair follicles may be one of the elements in the complex pathogenesis of AA. Nailfold videocapillaroscopy is a noninvasive technique that allows analysis of skin microcirculation in vivo. The aim of the study was the videocapillaroscopic assessment of skin microcirculation in AA patients. The study included 44 patients with patchy alopecia areata, 27 with alopecia universalis or totalis, and 40 healthy volunteers. Nailfold videocapillaroscopy was performed in all participants according to a standard protocol. Obtained images were assessed qualitatively and quantitatively. Two types of videocapillaroscopic images were distinguished in the study. Abnormal videocapillaroscopic images were found in 42% of patients. Tortuous and branching capillaries (P = 0.013, P = 0.001), decreased density of capillaries (P = 0.009), enlargement of the efferent limb (P < 0.017), or top part of the loop (P = 0.009) were observed significantly more often than in the control group. Only some patients with AA presented with microvascular abnormalities characterised by altered videocapillaroscopic images. More studies, including larger group of patients with AA, are required to determine the role of observed videocapillaroscopic alterations in AA.

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Section: Discussionsupporting

confidence: 60%

Videocapillaroscopic Alterations in Alopecia Areata

Gerkowicz

Krasowska

Pietrzak

et al. 2013

BioMed Research International

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“…A recent report declared that sympathectomy might cause cold sensitivity as a side effect (21). In addition, diminished capillary density was shown in AC (22). Considering these findings, the results of our study contradict the suggested physiopathological mechanism by which pure sympathetic over-activation plays a role in AC.…”

Section: Discussioncontrasting

confidence: 56%

Autonomic functions in acrocyanosis assessed by heart rate variability

et al. 2014

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Objective: To evaluate the autonomic activity of patients with acrocyanosis by using heart rate variability indices. Material and Methods: The study group consisted of 24 patients with acrocyanosis and the control group contained 22 sex-and age-matched healthy subjects. All subjects underwent 24-hour Holter monitoring. Among the heart rate variability (HRV) parameters, time-domain and frequency-domain indices were analysed. Results:The time-domain indices of HRV indicating global autonomic functions were found to be increased, and indices indicating parasympathetic activity showed a significant decrease in the patient group. Power-spectral analysis of HRV revealed that the low frequency and high frequency power were higher in the patient group than in controls. However, the ratio of Low Frequency/High Frequency was found to be lower in the patient group than in controls. Conclusion:In acrocyanosis, both sympathetic and parasympathetic systems seem to be disrupted. Therefore, we may conclude that acrocyanosis may be resulted of systemic autonomic imbalance rather than pure sympathetic over-activation. Also, these results suggest that acrocyanosis is not a localised disorder; on the contrary, it is associated with various abnormalities of the systemic autonomic nervous system.

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“…The lesions were evaluated with the handheld dermoscope (Delta 10; Heine Optotechnik, Germany), with a fixed magnification ×10, and photographed with the Dermaphot photographic equipment (Heine Optotechnik) after being covered with olive oil. In a first phase, we searched in both diseases for all those features described in classic capillaroscopy [1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17], pigmented tumors [18, 19, 20, 21, 22, 23]and also in our own reported experience [24, 25, 26, 27]. In addition, some new structures were found and described.…”

Section: Patients Methods and Definitionsmentioning

confidence: 99%

“…Because of the lack of specific vascular findings [6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16], these studies were abandoned [4]. The recent modifications of capillaroscopy have been made in the following way: increasing the technical complexity of the methods, with the introduction of videomicroscope [13, 14, 15, 16]and developing a more quantitative approach including digital imaging analysis, and dynamic techniques [1, 2, 3, 4, 5]. Except an isolated case of LP reported by us [24], this is the first large report renewing the theoretical and practical framework of surface microscopy of inflammatory dermatoses in another direction by using a simpler instrument (dermoscope) and by applying a method of analysis which includes nonvascular findings.…”

Section: Commentsmentioning

confidence: 99%

Dermoscopic Features of Plaque Psoriasis and Lichen Planus: New Observations

et al. 2003

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Background: Dermoscopic features of common inflammatory dermatoses are not well studied and previous reports on this topic are limited to the search of vascular features (capillaroscopy). Objective: Dermoscopic features of psoriasis and lichen planus (LP) are investigated to determine both vascular and nonvascular features of these two dermatoses. Patients and Methods: Dermoscopic images of 25 patients with LP and 20 patients with plaque psoriasis (PP) were evaluated. Findings were statistically analyzed including the reproducibility of scoring (Cohen’s kappa statistics). Results: Our observations clearly showed that the evaluation of both vascular and nonvascular findings improved the surface microscopy of these diseases. A vascular feature (homogeneous red globules) was the most significant dermoscopic finding in the PP dermoscopic pattern (20/20, 100%; p < 0.001). A nonvascular feature (whitish striae) was the most significant dermoscopic feature in the LP pattern (23/25, 92%; p < 0.001). Dermoscopic features of LP also included gray-blue dots, comedo, milium-like cysts, and vascular structures (red lines). The intraobserver and interobserver reproducibility of scoring was very high (k value, 0.9). Conclusion: Our study shows for the first time that the efficacy of surface microscopy of common inflammatory dermatoses may be improved by investigating both vascular and nonvascular findings and its practicability in daily practice by using the dermoscope. Although dermoscopy does not provide clear additional help in the clinical differentiation between typical PP and LP, it could be helpful in patients with darker skin and for teaching settings.

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Quantitative nailfold capillary microscopy findings in patients with acrocyanosis compared with patients having systemic sclerosis and control subjects

Cited by 31 publications

References 10 publications

Videocapillaroscopic Alterations in Alopecia Areata

Videocapillaroscopic Alterations in Alopecia Areata

Autonomic functions in acrocyanosis assessed by heart rate variability

Dermoscopic Features of Plaque Psoriasis and Lichen Planus: New Observations

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