Quantitative muscle ultrasound: a potential tool for assessment of disease activity in juvenile dermatomyositis

Bhansing, Kavish J.; Hoppenreijs, Esther; Janssen, Anjo J.W.M.; Royen‐Kerkhof, Annet van; Sanden, Maria W. G. Nijhuis-van der; Riel, P.L.C.M. van; Pillen, Sigrid

doi:10.3109/03009742.2013.879674

Cited by 27 publications

(25 citation statements)

References 9 publications

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“…At diagnosis, 4 of 5 patients had abnormal EI, which was similar to the sensitivity of QMUS found in previous studies (71% 22 to 86% 30 ). A previous review suggested that patients with acute myositis have an EI lower than normal.…”

Section: Discussionsupporting

confidence: 87%

“…It appears to be an objective and responsive technique for longitudinal followup of patients with Duchenne muscular dystrophy 20 ; studies in inflammatory myopathies have shown that ultrasound abnormalities resolve upon treatment in adults 21 and that QMUS discriminates between high and low disease activity measured cross-sectionally in JDM. 22 These findings indicate that ultrasonography could be useful for follow-up of JDM. In this study we explored QMUS characteristics together with clinical variables in longitudinal follow-up of a small cohort of patients with JDM.…”

mentioning

confidence: 82%

“…Quantitative muscle ultrasonography (QMUS) has had only limited longitudinal study in neuromuscular diseases. It appears to be an objective and responsive technique for longitudinal follow‐up of patients with Duchenne muscular dystrophy; studies in inflammatory myopathies have shown that ultrasound abnormalities resolve upon treatment in adults and that QMUS discriminates between high and low disease activity measured cross‐sectionally in JDM . These findings indicate that ultrasonography could be useful for follow‐up of JDM.…”

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confidence: 97%

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Quantitative muscle ultrasonography in the follow‐up of juvenile dermatomyositis

et al. 2015

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Section: Discussionsupporting

confidence: 87%

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confidence: 82%

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confidence: 97%

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Quantitative muscle ultrasonography in the follow‐up of juvenile dermatomyositis

et al. 2015

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“…Ultrasonography has been found in small patients cohorts (7–10 patients) to be a useful tool for myositis. 50 51 The expert group suggests that when MRI or muscle biopsy is not possible muscle ultrasonography may be an alternative to assess myositis activity.…”

Section: Resultsmentioning

confidence: 99%

Consensus-based recommendations for the management of juvenile dermatomyositis

et al. 2016

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BackgroundIn 2012, a European initiative called Single Hub and Access point for pediatric Rheumatology in Europe (SHARE) was launched to optimise and disseminate diagnostic and management regimens in Europe for children and young adults with rheumatic diseases. Juvenile dermatomyositis (JDM) is a rare disease within the group of paediatric rheumatic diseases (PRDs) and can lead to significant morbidity. Evidence-based guidelines are sparse and management is mostly based on physicians' experience. Consequently, treatment regimens differ throughout Europe.ObjectivesTo provide recommendations for diagnosis and treatment of JDM.MethodsRecommendations were developed by an evidence-informed consensus process using the European League Against Rheumatism standard operating procedures. A committee was constituted, consisting of 19 experienced paediatric rheumatologists and 2 experts in paediatric exercise physiology and physical therapy, mainly from Europe. Recommendations derived from a validated systematic literature review were evaluated by an online survey and subsequently discussed at two consensus meetings using nominal group technique. Recommendations were accepted if >80% agreement was reached.ResultsIn total, 7 overarching principles, 33 recommendations on diagnosis and 19 recommendations on therapy were accepted with >80% agreement among experts. Topics covered include assessment of skin, muscle and major organ involvement and suggested treatment pathways.ConclusionsThe SHARE initiative aims to identify best practices for treatment of patients suffering from PRD. Within this remit, recommendations for the diagnosis and treatment of JDM have been formulated by an evidence-informed consensus process to produce a standard of care for patients with JDM throughout Europe.

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“…However, in Africa and many other resource constrained economies, MRI may not be available in many centres and even where it is available, long waiting times, technical issues with reporting and cost implications may prove prohibitive. Thus additional diagnostic modalities such as muscle ultrasound and Bone scintigraphy that may provide cheaper and more convenient alternatives for demonstrating evidence of muscle inflammation may be welcome [28–30]. …”

Section: Discussionmentioning

confidence: 99%

Characteristics and outcome of children with juvenile dermatomyositis in Cape Town: a cross-sectional study

et al. 2016

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BackgroundJuvenile dermatomyositis (JDM) is a rare idiopathic inflammatory childhood myopathy of uncertain aetiology. The demographic and clinical presentation of JDM may differ by race and geographic regions. Few studies have described the characteristics of JDM patients from Africa.MethodsWe conducted a retrospective observational study to determine clinical characteristics and outcomes of patients satisfying the Bohan and Peter criteria for probable JDM seen between 2004 and 2013 in three hospitals in Cape Town, South Africa.ResultsTwenty five cases were identified: 16 female and 9 male; thirteen (52 %) were of indigenous African, eleven (44 %) mixed and one (4 %) European ancestry. The median ages at disease onset and diagnosis were 6.75 (range 2.0–9.7) and 7.9 (range 3.4–9.75) years respectively. Eleven patients had calcinosis while the mortality was 2/25 (8 %). Only 40 % of the patients had clinically inactive disease by PRINTO criteria (modified) at last review. There was no statistically significant difference in racial distribution (p-value = 1), age at disease onset (p-value = 0.87) and disease duration prior to treatment initiation (p-value = 0.75) between patients who had clinically active and inactive disease.ConclusionThe demographic characteristics of children with JDM were similar to that from most other regions of the world with female predominance and similar age at onset. Majority of the patients remained with clinically active disease, which put them at risk of further disease complications. Long term follow up and use of appropriate treatment guidelines may be indicated in management of JDM patients for optimum treatment outcomes.

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Quantitative muscle ultrasound: a potential tool for assessment of disease activity in juvenile dermatomyositis

Cited by 27 publications

References 9 publications

Quantitative muscle ultrasonography in the follow‐up of juvenile dermatomyositis

Quantitative muscle ultrasonography in the follow‐up of juvenile dermatomyositis

Consensus-based recommendations for the management of juvenile dermatomyositis

Characteristics and outcome of children with juvenile dermatomyositis in Cape Town: a cross-sectional study

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