Quantitative MRI T2 Relaxation Time Evaluation of Knee Cartilage

Li, Hong; Chen, Shuang; Tao, Hongyue; Chen, Shiyi

doi:10.1177/0363546514564151

Cited by 36 publications

(25 citation statements)

References 29 publications

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“…In contrast to the results aforementioned, a recent cohort study involving 62 participants showed no significant correlations between cartilage T2 relaxation times and International Knee Documentation Committee and Tegner Lysholm Scoring Scale outcomes after ACL reconstruction 23 . However, possible differences in the study population, different follow-up periods, and use of different patient-reported outcome measures make it difficult to compare the findings and might explain the discrepancies in the reported results from the previous and the present studies.…”

Section: Discussioncontrasting

confidence: 64%

“…Recent advances in quantitative MRI, such as T1ρ and T2, have been used to assess the biochemical matrix depletion of the cartilage in ACL-deficient and reconstructed knees 8, 21, 22 . However, to date, there has been little to no investigation on determining the relationship between these cartilage imaging techniques and patient-reported outcomes after ACLR 23 . Determining such a relationship may help clinicians provide more accurate functional expectations to patients prior to surgery.…”

Section: Introductionmentioning

confidence: 99%

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The association between MR T1ρ and T2 of cartilage and patient-reported outcomes after ACL injury and reconstruction

Pedoia

Teng

et al. 2016

Osteoarthritis and Cartilage

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Objective To determine if cartilage T1ρ and T2 relaxation time measures after ACL injury and prior to reconstruction (baseline) are associated with patient-reported outcomes at baseline, 6-months, and 1-year after surgery. Design Fifty-four ACL-injured participants were scanned in both knees at baseline using 3T MR T1ρ and T2 mapping. Participants also completed Knee-injury and Osteoarthritis Outcome Score (KOOS) and Marx activity level questionnaires at baseline, 6-months, and 1-year after reconstruction. The difference between cartilage T1ρ or T2 of the injured and contralateral knee (side-to-side difference, SSD) was calculated to account for physiological variations among patients. Linear regression models were built to evaluate the association between the baseline SSD T1ρ or T2 and KOOS or Marx at all time points. Results Higher baseline SSD T1ρ posterolateral tibia (pLT) was associated with worse KOOS in all subscales except symptoms at baseline, worse KOOS pain at 6-months, and worse KOOS in all subscales except sports function at 1-year. Higher baseline SSD T2 femoral trochlea was associated with worse KOOS activities of daily living at 1-year. Higher baseline SSD T1ρ pLT was associated with lower Marx activity level at 1-year. More severe cartilage lesions, as assessed by Whole-Organ MRI Scoring (WORMS), was significantly associated with worse KOOS pain at 6-months and 1-year. Conclusion T1ρ and T2 of cartilage after ACL injury were associated with KOOS after injury and both KOOS and Marx after reconstruction. Such associations may help clinicians stratify outcomes post-injury, and thus, improve patient management.

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Section: Discussioncontrasting

confidence: 64%

Section: Introductionmentioning

confidence: 99%

The association between MR T1ρ and T2 of cartilage and patient-reported outcomes after ACL injury and reconstruction

Pedoia

Teng

et al. 2016

Osteoarthritis and Cartilage

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“…Interestingly, the combined ACLR group exhibited less annual percentage cartilage volume increase than the isolated ACLR group (albeit only results for the lateral tibia reached significance). On face value, these results are somewhat counterintuitive as it was hypothesised (H 2 ) that the combined group would demonstrate a more pronounced cartilage increase than the isolated group given that concomitant meniscal pathology is a primary contributor to knee OA after ACLR [5, 41], and thus likely a contributor to post-ACLR cartilage swelling. An explanation for the paradoxical findings might relate to the fact that cartilage volume change was measured across the entire cartilage plate.…”

Section: Discussionmentioning

confidence: 89%

Tibiofemoral joint structural change from 2.5 to 4.5 years following ACL reconstruction with and without combined meniscal pathology

Wang

Bennell

Wang

et al. 2019

BMC Musculoskelet Disord

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Background People who have had anterior cruciate ligament reconstruction (ACLR) are at a high risk of developing tibiofemoral joint (TFJ) osteoarthritis (OA), with concomitant meniscal injury elevating this risk. This study aimed to investigate OA-related morphological change over 2 years in the TFJ among individuals who have undergone ACLR with or without concomitant meniscal pathology and in healthy controls. A secondary aim was to examine associations of baseline TFJ cartilage defects and bone marrow lesions (BML) scores with tibial cartilage volume change in ACLR groups. Methods Fifty seven ACLR participants aged 18–40 years (32 isolated ACLR, 25 combined meniscal pathology) underwent knee magnetic resonance imaging (MRI) 2.5 and 4.5 years post-surgery. Nine healthy controls underwent knee MRI at the ~ 2-year intervals. Tibial cartilage volume, TFJ cartilage defects and BMLs were assessed from MRI. Results For both ACLR groups, medial and lateral tibial cartilage volume increased over 2 years ( P < 0.05). Isolated ACLR group had greater annual percentage increase in lateral tibial cartilage volume compared with controls and with the combined group ( P = 0.03). Cartilage defects remained unchanged across groups. Both ACLR groups showed more lateral tibia BML regression compared with controls ( P = 0.04). Baseline cartilage defects score was positively associated with cartilage volume increase at lateral tibia ( P = 0.002) while baseline BMLs score was inversely related to medial tibia cartilage volume increase ( P = 0.001) in the pooled ACLR group. Conclusions Tibial cartilage hypertrophy was apparent in ACLR knees from 2.5 to 4.5 years post-surgery and was partly dependent upon meniscal status together with the nature and location of the underlying pathology at baseline. Magnitude and direction of change in joint pathologies (i.e., cartilage defects, BMLs) were less predictable and either remained stable or improved over follow-up. Electronic supplementary material The online version of this article (10.1186/s12891-019-2687-9) contains supplementary material, which is available to authorized users.

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“…Others reported a decrease in collagen content, but an increase in proteoglycan content in osteoarthritic menisci [ 23 ]. There are some studies, however, that have examined quantitative MRI, such as T2 mapping, as a biomarker for meniscal or cartilage degeneration [ 1 , 30 , 31 , 32 , 33 , 34 , 35 ]. Histological grading has not been performed regularly, but most studies demonstrated that T2 mapping can differentiate between healthy patients and patients with osteoarthritis.…”

Section: Discussionmentioning

confidence: 99%

Histological Findings and T2 Relaxation Time in Canine Menisci of Elderly Dogs—An Ex Vivo Study in Stifle Joints

Bunzendahl

Moussavi

Bleyer

et al. 2023

Veterinary Sciences

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Osteoarthritis is a chronic disease that often affects the canine stifle joint. Due to their biomechanical function, the menisci in the canine stifle play an important role in osteoarthritis. They compensate for the incongruence in the joint and distribute and minimize compressive loads, protecting the hyaline articular cartilage from damage. Meniscal degeneration favors the development and progression of stifle joint osteoarthritis. Qualitative magnetic resonance imaging (MRI) is the current golden standard for detecting meniscal changes, but it has limitations in detecting early signs of meniscal degeneration. A quantitative MRI offers new options for detecting early structural changes. T2 mapping can especially visualize structural changes such as altered collagen structures and water content, as well as deviations in proteoglycan content. This study evaluated T2 mapping and performed a histological scoring of menisci in elderly dogs that had no or only low radiographic osteoarthritis grades. A total of 16 stifles from 8 older dogs of different sex and breed underwent ex vivo magnet resonance imaging, including a T2 mapping pulse sequence with multiple echoes. A histological analysis of corresponding menisci was performed using a modified scoring system. The mean T2 relaxation time was 18.2 ms and the mean histological score was 4.25. Descriptive statistics did not reveal a correlation between T2 relaxation time and histological score. Ex vivo T2 mapping of canine menisci did not demonstrate histological changes, suggesting that early meniscal degeneration can be present in the absence of radiological signs of osteoarthritis, including no significant changes in T2 relaxation time.

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Quantitative MRI T2 Relaxation Time Evaluation of Knee Cartilage

Cited by 36 publications

References 29 publications

The association between MR T1ρ and T2 of cartilage and patient-reported outcomes after ACL injury and reconstruction

The association between MR T1ρ and T2 of cartilage and patient-reported outcomes after ACL injury and reconstruction

Tibiofemoral joint structural change from 2.5 to 4.5 years following ACL reconstruction with and without combined meniscal pathology

Histological Findings and T2 Relaxation Time in Canine Menisci of Elderly Dogs—An Ex Vivo Study in Stifle Joints

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