Quantitative MRI in murine radiation‐induced rectocolitis: comparison with histopathological inflammation score

Zappa, Magaly; Doblas, Sabrina; Cazals–Hatem, Dominique; Milliat, Fabien; Lavigne, Jérémy; Daniel, Fanny; Jallane, Abelhak; Garteiser, Philippe; Vilgrain, Valérie; Ogier–Denis, Éric; Beers, Bernard E. Van

doi:10.1002/nbm.3897

Cited by 9 publications

(5 citation statements)

References 27 publications

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“…Compared to the max ADC spine, mean ADC spine appeared to give better description to disease activity. The ability of ADC in quantifying inflammation has been demonstrated in previous studies 18‐20 and its usage has been validated in axial SpA 9 . In contrast, the currently recommended STIR imaging poorly visualizes intensity of inflammation.…”

Section: Discussionmentioning

confidence: 95%

Both ASDAS and ADC are associated with spinal mobility in active axial spondyloarthritis: A comparison between early and later disease

et al. 2022

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Objective Using diffusion‐weighted imaging (DWI)‐derived apparent diffusion coefficient (ADC), we aimed to determine the relationship between intensity of spinal inflammation and mobility in patients with axial spondyloarthritis (SpA) in early and later stages of active disease. The Ankylosing Spondylitis Disease Activity Score (ASDAS) was also used for a more comprehensive evaluation. Methods Participants with axial SpA and back pain were recruited from 10 rheumatology centers. Clinical, biochemical and radiological parameters were collected. Short tau inversion recovery (STIR) sequence magnetic resonance imaging (MRI) and DWI of the spine and sacroiliac (SI) joints were performed. ADC maps were generated. Participants were examined for Bath Ankylosing Spondylitis Metrology Index (BASMI). Linear regression models were used to determine associations between BASMI and various clinical, radiological, and MRI parameters in participants with active inflammation on spinal ADC maps. Results One‐hundred and twenty‐seven participants were included in the analyses. Multivariate linear regression showed that mean ADC spine (ß = .16; P = .03), ASDAS‐C‐reactive protein (CRP) (ß = .29, P < .001), and ASDAS‐erythrocyte sedimentation rate (ESR) (ß = .25, P < .01) were associated with BASMI. In participants with duration of back pain ≤3 years, mean spine ADC (ß = .37; P = .03), ASDAS‐CRP (ß = .44; P = .01), and ASDAS‐ESR (ß = .42; P = .01) were associated with BASMI after adjustment for confounding factors. In participants with duration of back pain >3 years, only ASDAS‐CRP (ß = .25; P < .01) and ASDAS‐ESR (ß = .20; P = .20) were associated with BASMI. Conclusion Intensity of inflammation and clinical disease activity were independently associated with impairment of spinal mobility. The associations were stronger in early (≤3 years) than later disease.

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Section: Discussionmentioning

confidence: 95%

Both ASDAS and ADC are associated with spinal mobility in active axial spondyloarthritis: A comparison between early and later disease

et al. 2022

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“…STIR sequence is highly effective in demonstrating the extent of inflammation, but DWI-ADC allows measurement of intensity. The ability of DWI-ADC in quantifying inflammation intensity has been demonstrated in various diseases 25–27. In previous studies, ADC values were found to correlate with CRP in patients with SpA28 and to be increased in active sacroiliitis 29.…”

Section: Discussionmentioning

confidence: 98%

ASDAS is associated with both the extent and intensity of DW-MRI spinal inflammation in active axial spondyloarthritis

et al. 2019

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ObjectiveTo investigate the relationship between Ankylosing Spondylitis Disease Activity Score (ASDAS) and intensity of spinal inflammation measured by apparent diffusion coefficient (ADC) in MRI in participants with active axial spondyloarthritis (SpA).MethodsParticipants with axial SpA and back pain were recruited. Clinical, demographic, biochemical and imaging data were collected. ASDAS was calculated based on C reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Inflammatory lesions were identified in short tau inversion recovery images and the corresponding ADC maps to determine the maximum apparent diffusion coefficient (ADCmax), normalised maximum ADC, mean apparent diffusion coefficient (ADCmean) and normalised mean ADC by two independent readers. Spondyloarthritis Research Consortium of Canada (SPARCC) spine and sacroiliac (SI) joint MRI indexes were determined. Univariate and multivariate linear regression models were used to determine the associations between of ASDAS with ADC values, SPARCC spine and SI MRI scores.ResultsEighty-two participants had identifiable ADC lesions. Multivariate analyses using ADCmax and SPARCC spine MRI as independent variables showed associations with ASDAS-CRP (ADCmax: B=0.27, p=0.02; SPARCC: B=0.32, p=0.01) and ASDAS-ESR (ADCmax: B=0.24, p=0.03; SPARCC: B=0.36, p<0.01); using ADCmean and SPARCC spine MRI as independent variables also showed an association with ASDAS-ESR (ADCmean: B=0.22, p=0.05; SPARCC: B=0.36, p<0.01) and a tendency to associate with ASDAS-CRP (ADCmean: B=0.21, p=0.07; SPARCC: B=0.34, p<0.01).ConclusionASDAS is associated with both the extent and the intensity of spinal inflammation in patients with detectable inflammatory lesions. Our results showed that ASDAS is an objective disease assessment tool.Trial registration numberHKUCTR-2087.

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“…ADC values have been consistently shown to be effective in quantifying the intensity of inflammation in various diseases. [ 23 – 25 ] In contrast, no association was found with the SPARCC spine MRI score, which used STIR sequence that preferentially measures the extent rather than the intensity of inflammation. Since we only included participants with current back pain, our cohort had higher percentage of MRI inflammation when compared to the international study.…”

Section: Discussionmentioning

confidence: 99%

Clinical, radiological, and magnetic resonance imaging characteristics of axial spondyloarthritis with late onset

et al. 2022

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We aimed to investigate the clinical, diagnostic, and imaging features of patients with late onset axial spondyloarthritis (SpA) with initial symptom manifestation aged over 45 years. Participants with axial SpA were consecutively recruited. Clinical, demographic, blood, and imaging parameters were compared between the groups with early (≤45 years) and late onset (>45 years) at a cross-sectional level. Logistic regressions were used to determine the independent associations with axial SpA with late onset. A total of 455 participants were recruited. Among them, 70 (15.4%) had late onset disease. Multivariate analyses showed that axial SpA with late onset was associated with higher C-reactive protein based ankylosing spondylitis disease activity index (ASDAS-CRP) (B = 0.10; P = .04), higher intensity of spinal inflammation as measured by maximum apparent diffusion coefficient (spinal ADC max) (B = 0.27; P = .03) and mean ADC (spinal ADC mean) (B = 0.30; P = .004), lower modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) (B = –0.12; P = .02), more tender joint count (B = 0.12; P = .02), and fewer inflammatory back pain (IBP) (OR = 0.26; P < .001). Axial SpA with late onset had higher clinical disease activity, higher intensity of spinal MRI inflammation, less radiographic damage, and more tender joint count. There was also less inflammatory back pain, which could make the diagnosis more difficult.

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Quantitative MRI in murine radiation‐induced rectocolitis: comparison with histopathological inflammation score

Cited by 9 publications

References 27 publications

Both ASDAS and ADC are associated with spinal mobility in active axial spondyloarthritis: A comparison between early and later disease

Both ASDAS and ADC are associated with spinal mobility in active axial spondyloarthritis: A comparison between early and later disease

ASDAS is associated with both the extent and intensity of DW-MRI spinal inflammation in active axial spondyloarthritis

Clinical, radiological, and magnetic resonance imaging characteristics of axial spondyloarthritis with late onset

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