Quantitative MRI for hepatic fat fraction and T2* measurement in pediatric patients with non-alcoholic fatty liver disease

Deng, Jie; Fishbein, Mark; Rigsby, Cynthia K.; Zhang, Gang; Schoeneman, Samantha E.; Donaldson, James S.

doi:10.1007/s00247-014-3024-y

Cited by 31 publications

(23 citation statements)

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“…In prior pediatric studies, there was a correlation between MRI‐estimated liver fat and steatosis grade of 0.88‐0.90. However, these studies had small sample sizes with a total of 10‐25 cases with histology and controls with no histology . In general, the highest correlations have been found in studies with the smallest population sample sizes and/or with the greatest skew.…”

Section: Discussionmentioning

confidence: 99%

Magnetic resonance imaging and liver histology as biomarkers of hepatic steatosis in children with nonalcoholic fatty liver disease

et al. 2015

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Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in children. In order to advance the field of NAFLD, noninvasive imaging methods for measuring liver fat are needed. Advanced magnetic resonance imaging (MRI) has shown great promise for the quantitative assessment of hepatic steatosis but has not been validated in children. Therefore, this study was designed to evaluate the correlation and diagnostic accuracy of MRI-estimated liver proton density fat fraction (PDFF), a biomarker for hepatic steatosis, compared to histologic steatosis grade in children. The study included 174 children with a mean age of 14.0 years. MRI-estimated liver PDFF was significantly (p < 0.01) correlated (0.725) with steatosis grade. Correlation of MRI-estimated liver PDFF and steatosis grade was influenced by both sex and fibrosis stage. The correlation was significantly (p<0.01) stronger in girls (0.86) than in boys (0.70). The correlation was significantly (p<0.01) weaker in children with stage 2–4 fibrosis (0.61) than children with no fibrosis (0.76) or stage 1 fibrosis (0.78). The diagnostic accuracy of commonly used threshold values to distinguish between no steatosis and mild steatosis ranged from 0.69 to 0.82. The overall accuracy of predicting the histologic steatosis grade from MRI-estimated liver PDFF was 56%. No single threshold had sufficient sensitivity and specificity to be considered diagnostic for an individual child. Conclusions Advanced magnitude-based MRI can be used to estimate liver PDFF in children, and those PDFF values correlate well with steatosis grade by liver histology. Thus magnitude-based MRI has the potential for clinical utility in the evaluation of NAFLD, but at this time no single threshold value has sufficient accuracy to be considered diagnostic for an individual child.

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Section: Discussionmentioning

confidence: 99%

Magnetic resonance imaging and liver histology as biomarkers of hepatic steatosis in children with nonalcoholic fatty liver disease

et al. 2015

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“…1. The accuracy of the fat percentage measurement in a fat phantom and in patients with fatty liver disease had been previously validated [34].…”

Section: Post-processingmentioning

confidence: 99%

MRI characterization of brown adipose tissue in obese and normal-weight children

et al. 2015

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“…Correspondence to: Dr. Mona Zaky, The Department of Diagnostic Radiology, Faculty of Medicine, Mansoura University Non-Alcoholic Fatty Liver Disease (NAFLD) ranges from simple steatosis to NAFLD-related liver cirrhosis and is a main cause of chronic liver diseases, which is characterized by hepatocyte injury, inflammation, and can further progress into more advanced stage of fibrosis/cirrhosis [2,3] . NASH also increases the risk of liver cancer development as well as death from cardiovascular disease [4][5][6] .…”

Section: Non-alcoholic Fatty Liver Disease (Nafld)mentioning

confidence: 99%

Can We Rely on mDixon Technique on Quantification of Hepatic Steatosis?

Elalfy

2019

The Medical Journal of Cairo University

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Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is currently the outstanding cause of chronic liver disease. Magnetic Resonance (MR) is widely used in clinical trials to noninvasively quantify liver fat content. Aim of Study:To determine the accuracy of mDixon MR technique in quantification of liver fat and correlate the results with liver biopsy. Material and Methods:A prospective study was conducted at Mansoura University Hospitals between March 2017 to November 2018. This study included forty two patients who were referred from gastroenterology clinic for non-hepatic complaints. Clinical examination and estimation of body mass index was recorded in all patients. Abdominal ultrasonography was done to all patients only to exclude focal lesions and gross morphological changes, then MRI evaluation of the upper abdomen using the mDixon protocol. Within a week interval period, patients had liver biopsy.Results: There was good correlation between the MR estimation of liver fat and histological grading, yielding sensitivity of 83.3% and specificity of 85.7% with accuracy of 84.62% at cut off point of 14.545.Conclusion: MR estimation of the liver using mDixon technique provided specific information about liver fat, correlated well with the histological grading. Non invasive technique, does not require ionising radiation hence recommended as method of choice of liver fat quantification.

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Quantitative MRI for hepatic fat fraction and T2* measurement in pediatric patients with non-alcoholic fatty liver disease

Cited by 31 publications

References 23 publications

Magnetic resonance imaging and liver histology as biomarkers of hepatic steatosis in children with nonalcoholic fatty liver disease

Magnetic resonance imaging and liver histology as biomarkers of hepatic steatosis in children with nonalcoholic fatty liver disease

MRI characterization of brown adipose tissue in obese and normal-weight children

Can We Rely on mDixon Technique on Quantification of Hepatic Steatosis?

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