Quantitative MRI criteria for optic pathway enlargement in neurofibromatosis type 1

Abstract

Quantitative reference values for AVP enlargement will enhance the development of objective diagnostic criteria for OPGs secondary to NF1.

Prognostic Role of Conventional and Dynamic Contrast‐Enhanced MRI in Optic Pathway Gliomas

“…Of the 299 patients who underwent MRI for evaluation of OPG at MD Anderson Cancer Center between January 2010 and December 2016, a total of 23 OPG patients who underwent both conventional MRI and DCE MRI of the orbit were identified. The diagnosis of OPG was based on radiological criteria, including generalized or focal enlargement, presence of T2 hyperintensity, and/or associated enhancement of the involved optic pathway . The OPG lesions were categorized into clinically progressive form and nonprogressive form.…”

Optic pathway glioma volume predicts retinal axon degeneration in neurofibromatosis type 1

“…MRI segmentation and volumetric analysis was performed as previously described. 9,16 Briefly, both optic nerves, the optic chiasm, and the proximal portion of the optic tracts were manually segmented using the MRI sequence. Segmentation of the optic tracts was limited to 10 millimeters beyond the chiasm as reliable visualization beyond this point was variable among patients.…”

“…Novel volumetric MRI segmentation algorithms can now perform comprehensive measurements of discrete structures along the AVP. [9][10][11] Retinal nerve fiber layer thickness (RNFL), measured by optical coherence tomography (OCT), is an assessment of AVP axonal damage and is an established biomarker and visual outcome measure for children with NF1-OPGs. [12][13][14] In this study, we investigated whether OPG size is related to axonal damage of the AVP in children with NF1.…”

“…Patients with previously reported MRI volumetric measures were included in this cohort. 9 Standard protocol approvals, registrations, and patient consents. This retrospective study was approved by the Children's National Health System institutional review board.…”

Optic chiasm measurements may be useful markers of anterior optic pathway degeneration in neuromyelitis optica spectrum disorders

“…In addition to the accumulation of damage within the anterior optic pathway, the OC appears particularly promising as a potential imaging marker, since it would simplify evaluation by reducing the region of interest from multiple structures to one. Only few studies have focused on the assessment of physiologic OC dimensions [31][32][33] and their changes in optic atrophy [18], while quantitative correlation analysis to visual function and optic pathway degeneration has not been performed.…”