Quantitative MR in the diagnosis of multiple sclerosis

Haughton, Victor M.; Yetkin, Funda; Rao, Stephen M.; Rimm, Alfred A.; Fischer, Marius; Papke, R A; Breger, R K; Khatri, B. O.

doi:10.1002/mrm.1910260108

Cited by 35 publications

(15 citation statements)

References 21 publications

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“…In the group of seven MS patients in which serial observations were obtained, MTR histograms showed a decrease in peak height over an average time of 25 months. Although these results are preliminary, and obtained in a small series of patients, the finding is statistically significant.…”

Section: Discussionmentioning

confidence: 95%

Quantitative volumetric magnetization transfer analysis in multiple sclerosis: Estimation of macroscopic and microscopic disease burden

Buchem

McGowan²,

Kolson

et al. 1996

Magnetic Resonance in Med

200

138

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Magnetization transfer imaging (MTI) has been shown to be sensitive to both macroscopic and microscopic disease in multiple sclerosis (MS). In this study three-dimensional MTI was used to estimate the global burden of disease in large volumes of brain tissue. MTI was performed in 15 MS patients and 11 normal controls. In seven MS patients MTI was performed on two different occasions. MTI data were displayed as magnetization transfer ratio (MTR) histograms and analyzed. The peak height of the histograms, presumably reflecting the residual amount of normal brain tissue, was lower in MS patients as compared with normal controls (P < 0.001), and was found to correlate with the duration of disease (P < 0.05). A decrease of the MTR histogram peak height was observed in the course of the disease (P < 0.01). These findings suggest that in MS, volumetric MTI provides quantitative information reflecting the global burden of disease.

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Section: Discussionmentioning

confidence: 95%

Quantitative volumetric magnetization transfer analysis in multiple sclerosis: Estimation of macroscopic and microscopic disease burden

Buchem

McGowan²,

Kolson

et al. 1996

Magnetic Resonance in Med

200

138

View full text Add to dashboard Cite

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“…Haughton et al (44) found significantly longer Tl and T,, which also correlated with the severity of the disease, in apparently uninvolved white matter of patients with MS compared with healthy controls. A multiecho MRI sequence without contrast agent was used.…”

Section: Discussionmentioning

confidence: 96%

Proton MRS of Gadolinium‐enhancing MS Plaques and Metabolic Changes in Normal‐Appearing White Matter

Roser

Hagberg

Mader

et al. 1995

Magnetic Resonance in Med

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Localized short echo time (TE = 20 ms), stimulated echo acquisition mode, and double spin echo (TE = 135 ms) proton spectroscopy were performed in clearly defined, acute Gadolinium (Gd)-enhancing multiple sclerosis (MS) plaques of 22 patients with clinically definite MS. The resonances of N-acetylated metabolites (NA), creatine/phosphocreatine (Cr), choline-containing compounds (Cho), glycine/myo-inositol (Ino), and lactate were evaluated. The ratios of NA/Cr and NA/Cho were significantly decreased, Cho/Cr increased, and Ino/Cr remained unchanged. No marker peaks or elevated lactate levels were found. The measured metabolic changes were practically independent of the relative plaque size within the volume of interest (8 ml). Thus, the spectral changes measured with 1H MRS in acute Gd-enhancing MS plaques originate not only from the lesion as depicted by MRI, but also from the surrounding normal-appearing white matter.

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“…On the other hand,Husted and Pan [42,43] have reported indirect evidence of increased Cr in the NAWM. Until the present conflicting results have been published regarding the Cr concentration [44][45][46].…”

Section: Discussionmentioning

confidence: 99%

Evidence of Wallerian degeneration in normal appearing white matter in the early stages of relapsing-remitting multiple sclerosis

Casanova¹,

Martínez-Bisbal

Valero³

et al. 2003

Journal of Neurology

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Quantitative MR in the diagnosis of multiple sclerosis

Cited by 35 publications

References 21 publications

Quantitative volumetric magnetization transfer analysis in multiple sclerosis: Estimation of macroscopic and microscopic disease burden

Quantitative volumetric magnetization transfer analysis in multiple sclerosis: Estimation of macroscopic and microscopic disease burden

Proton MRS of Gadolinium‐enhancing MS Plaques and Metabolic Changes in Normal‐Appearing White Matter

Evidence of Wallerian degeneration in normal appearing white matter in the early stages of relapsing-remitting multiple sclerosis

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