Quantitative Motor Functioning in Prodromal Parkinson Disease

Dommershuijsen, Lisanne J.; Ikram, M. Kamran; Darweesh, Sirwan K.L.

doi:10.1002/ana.25606

Cited by 1 publication

(1 citation statement)

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“…These parameters were not examined in Del Din et al study, including arm range of motion, arm range of motion variation, peak arm velocity asymmetry, and trunk sagittal range of motion. It is important to determine to what extent these predictors may overlap [34], and our results showed that certain parameters indeed exhibited strong correlations. Future evaluations of iRBD gait analysis may only involve selected parameters and call for more precise assessments involving diverse body areas that are commonly affected in α-synuleinopathies.…”

Section: Discussionmentioning

confidence: 88%

Gait Analysis with Wearable Sensors in Isolated REM Sleep Behavior Disorder Associated with Phenoconversion: An Explorative Study

Cen,

Zhang,

et al. 2024

JPD

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Background: Gait disturbance is a vital characteristic of motor manifestation in α– synucleinopathies, especially Parkinson’s disease. Subtle gait alterations are present in isolated rapid eye movement sleep behavior disorder (iRBD) patients before phenoconversion; it is yet unclear, if gait analysis may predict phenoconversion. Objective: To investigate subtle gait alterations and explore whether gait analysis using wearable sensors is associated with phenoconversion of iRBD to α-synucleinopathies. Methods: Thirty-one polysomnography-confirmed iRBD patients and 33 healthy controls (HCs) were enrolled at baseline. All participants walked for a minute while wearing 6 inertial sensors on bilateral wrists, ankles, and the trunk (sternal and lumbar region). Three conditions were tested: (i) normal walking, (ii) fast walking, and (iii) dual-task walking. Results: Decreased arm range of motion and increased gait variation (stride length, stride time and stride velocity) discriminate converters from HCs at baseline. After an average of 5.40 years of follow-up, 10 patients converted to neurodegenerative diseases (converters). Cox regression analysis showed higher value of stride length asymmetry under normal walking condition to be associated with an early conversion of iRBD to α– synucleinopathies (adjusted HR 4.468, 95% CI 1.088– 18.349, p = 0.038). Conclusions: Stride length asymmetry is associated with progression to α– synucleinopathies in patients with iRBD. Gait analysis with wearable sensors may be useful for screening, monitoring, and risk stratification for disease-modifying therapy trials in patients with iRBD.

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Section: Discussionmentioning

confidence: 88%