Quantitative Morphology of Experimental Fibrosis in Canine Pancreas after Laser Tunneling

Abstract

Dogs with experimental fibrosing pancreatitis were subjected to laser tunneling to assess its effect on the dynamics of some morphometric indices of the pancreas. On post-tunneling day 60, volume ratio of the parenchyma significantly increased while the volume ratio of the stroma decreased in comparison to the dogs with fibrosing pancreatitis not corrected by laser tunneling.

A score model based on pancreatic steatosis and fibrosis and pancreatic duct diameter to predict postoperative pancreatic fistula after Pancreatoduodenectomy

“…In this study’s systematic reviews, research indicated that low PF and high PS were risk factors for pancreatic leakage after pancreatic resection. One of the hypotheses is that the fiber and adipose tissue replace the normal pancreatic parenchyma destroying the normal microstructure of the pancreas, ultimately leading to changes in pancreatic texture [34–36]. Fatty infiltration in the pancreas makes the tissue more fragile, making anastomosis of the pancreas and intestine more easily disrupted, while deposition of fibrous tissue in the pancreas makes the tissue firm and reduces the complications in surgical operation [37].…”