Quantitative modeling of the anisotropy of ultrasonic backscatter from canine myocardium

Kumar, Krishna N.; Mottley, Jack G.

doi:10.1109/58.294103

Cited by 14 publications

(4 citation statements)

References 24 publications

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“…The line profile data represents that corresponding to the bisecting line for each specimen as indicated in Figure 3b. The nature of the transmural line profiles depicted in Figures 6 appears consistent with what would be anticipated based on previously published studies examining the effects of anisotropy on ultrasonic parameters (Baldwin et al 2006; Hall et al 1997; Hoffmeister et al 1995; Kumar and Mottley 1994; Madaras et al 1988; Mottley and Miller 1988; Mottley and Miller 1990; Sosnovik et al 2001; Verdonk et al 1996). Specifically, these studies demonstrated that maximum values of apparent backscatter with minimum levels of attenuation are associated with perpendicular insonification relative to the myofibers whereas, for non-perpendicular insonification larger levels of attenuation and smaller levels of apparent backscatter are observed.…”

Section: Discussionsupporting

confidence: 88%

Measurements of Ultrasonic Attenuation Properties of Midgestational Fetal Pig Hearts

Gibson¹,

Singh²,

Hoffman³

et al. 2009

Ultrasound in Medicine & Biology

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The objectives of this study were to measure the relative attenuation properties of the left and right ventricles in fetal pig hearts and to compare the spatial variation in attenuation measurements with those observed in previously published backscatter measurements. Approximately 1.0 mm thick, short-axis slices of excised, formalin-fixed heart were examined from 15 mid-gestational fetal pigs using a 50-MHz single-element transducer. Measurements of the attenuation properties demonstrate regional differences in the left and right ventricular myocardium that appear consistent with the previously reported regional differences in apparent integrated backscatter measurements of the same fetal pig hearts. For regions of perpendicular insonification relative to the myofiber orientation, the right ventricular free wall showed larger values for the slope of the attenuation coefficient from 30-60 MHz (1.48 ± 0.22 dB/(cm•MHz) (mean ± SD (standard deviation)) and attenuation coefficient at 45 MHz (46.3 ± 7.3 dB/cm (mean ± SD)) than the left ventricular free wall (1.18 ± 0.24 dB/(cm•MHz) and 37.0 ± 7.9 dB/cm (mean ± SD) for slope of attenuation coefficient and attenuation coefficient at 45 MHz, respectively). This attenuation study supports the hypothesis that intrinsic differences in the myocardium of the left and right ventricles exist in fetal pig hearts at mid-gestation.

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Section: Discussionsupporting

confidence: 88%

Measurements of Ultrasonic Attenuation Properties of Midgestational Fetal Pig Hearts

Gibson¹,

Singh²,

Hoffman³

et al. 2009

Ultrasound in Medicine & Biology

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“…(Gong et al 2006; Hall et al 2000; Holland et al 2004; Kumar and Mottley 1994; Micari et al 2006; O'Brien et al 1995a; Rose et al 1995; Wickline et al 1985a) In addition to mechanisms associated with changes in fiber orientation, changes in myocardial blood volume, scatterer size, shape and concentration as well as relative intra- and extracellular acoustic impedances over the heart cycle may all play a role. In particular, it may be instructive to determine whether the results observed in this study are consistent with what might be anticipated based on a previously described model of the cyclic variation of backscatter properties of myocardium.…”

Section: Discussionmentioning

confidence: 99%

“…The nature of the intrinsic myocardial properties (e.g., the types and concentrations of proteins present and the resulting specific intra- and extracellular viscoelastic properties) as well as the geometrical properties (structural morphology) of the myocardium, combine to produce the observed ultrasonic parameters. (Hall et al 2000; Hoyt et al 1984; Kumar and Mottley 1994; Mimbs et al 1980; O'Brien et al 1995a; O'Brien et al 1995b; Rose et al 1995; Wickline et al 1985a) For example, several studies have illustrated the relationship between the measured ultrasonic backscatter properties and collagen content in myocardial tissue. (Hall et al 2000; Hoyt et al 1984; Mimbs et al 1980; O'Donnell et al 1981; Pohlhammer and O'Brien 1981) Results demonstrated an increase in both the measured ultrasonic attenuation and backscatter correlate well with increased collagen concentration determined biochemically or histologically.…”

Section: Introductionmentioning

confidence: 99%

Echocardiographic Tissue Characterization Demonstrates Differences in the Left and Right Sides of the Ventricular Septum

Holland

Gibson

Bauer

et al. 2010

Ultrasound in Medicine & Biology

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The left and right ventricular function of the heart are influenced by the complex structure of the ventricular septum. The cyclic variation of ultrasonic backscatter over the cardiac cycle is known to be sensitive to both structural and functional characteristics of the myocardium. The objective of this study was to investigate differences in the measured magnitude and normalized delay of cyclic variation between the left and right sides of the ventricular septum in normal adult subjects (N=31). The measured mean magnitudes of cyclic variation were found to be 4.9 ± 0.4 dB and 2.4 ± 0.3 dB (mean ± SE; p < 0.0001) and the corresponding normalized delay values were found to be 0.94 ± 0.05 and 1.59 ± 0.12 (mean ± SE; p < 0.0001) for the left and right sides, respectively. These results show significant differences in the measured magnitude and normalized delay of cyclic variation between the left and right sides of the ventricular septum in normal subjects that appear consistent with predictions based on previously described models of cyclic variation of backscatter and reported measurements of transmural differences in strain properties of the septum.

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“…The two-sided power distribution is typically used as a subjective description of a population for which there are only limited sample data, and especially in cases where the relationship between variables is known but data are scarce possibly because of the high cost of collection. This distribution is a generalization of the well-known uniform distribution, which has widespread applications to ultrasound, see Li et al (1992), Donohue et al (1993), Kumar and Mottley (1994), Guidi et al (1995), Kosinski et al (1996), and Narayanan et al (1997). Note that p and m are the shape parameters while a and b are the scale parameters.…”

Section: Four-parameter Two-sided Power Distributionmentioning

confidence: 96%

Statistical distributions of potential interest in ultrasound speckle analysis

Nadarajah¹

2007

Phys. Med. Biol.

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Compound statistical modelling of the uncompressed envelope of the backscattered signal has received much interest recently. In this note, a comprehensive collection of models is derived for the uncompressed envelope of the backscattered signal by compounding the Nakagami distribution with 13 flexible families. The corresponding estimation procedures are derived by the method of moments and the method of maximum likelihood. The sensitivity of the models to their various parameters is examined. It is expected that this work could serve as a useful reference and lead to improved modelling of the uncompressed envelope of the backscattered signal.

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Quantitative modeling of the anisotropy of ultrasonic backscatter from canine myocardium

Cited by 14 publications

References 24 publications

Measurements of Ultrasonic Attenuation Properties of Midgestational Fetal Pig Hearts

Measurements of Ultrasonic Attenuation Properties of Midgestational Fetal Pig Hearts

Echocardiographic Tissue Characterization Demonstrates Differences in the Left and Right Sides of the Ventricular Septum

Statistical distributions of potential interest in ultrasound speckle analysis

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